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991.
应用伽玛刀治疗脑深部和功能区海绵状血管瘤 总被引:3,自引:0,他引:3
雷鹏 《立体定向和功能性神经外科杂志》1999,12(4):27-29
目的: 探讨伽玛刀对脑深部和功能区海绵状血管瘤(CA) 的治疗效果及有关问题。方法: 采用伽玛刀对67 例大脑半球深部、丘脑、基底节及脑干海绵状血管瘤进行治疗。结果: 随访3 月~8 年 (平均2.6 年), 评价其治疗效果, 2 例死于其他疾病, 6 例行手术治疗。在MRI检查随访59 例中, 病变稳定好转率达98% , 并且年再出血发生率大大降低。结论: 应用伽玛刀治疗脑深部及险要部位的CA 是一种无创伤、效果比较好的方法。 相似文献
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994.
E. Bayever N. Kamani P. Ferreira G. A. Machin M. Yudkoff K. Conard M. Palmieri J. Radcliffe D. A. Wenger C. S. August 《Journal of inherited metabolic disease》1992,15(6):919-928
Summary Bone marrow transplantation has been undertaken with encouraging results as therapy for a wide variety of lysosomal storage diseases. We report a case of Niemann-Pick disease Type IA in which, despite the presence of only mild hypotonia with depressed reflexes, the clinical course of the disease appeared to be only slightly modified by this procedure, which was performed at the earliest practical opportunity. The patient was diagnosed early when asymptomatic, because of a family history of an affected sibling who died at 14 months. He received a bone marrow transplant from an HLA-identical, MLC non-reactive sibling donor, whose leukocyte sphingomyelinase activity was in the homozygote normal range. There was adequate engraftment as evidenced by persistently normal leukocyte sphingomyelinase activities, and there was no evidence of graft-versus-host disease. Visceral storage and neurological impairment were less rapidly progressive than in his untreated sibling but he eventually died at 30 months. Autopsy confirmed that this was essentially due to the effects of the underlying Niemann-Pick disease. We conclude that despite some success in other neurovisceral lysosomal storage disorders, bone marrow transplantation is not likely to be an adequate treatment for Niemann-Pick disease Type IA. 相似文献
995.
Mieres JH Shaw LJ Arai A Budoff MJ Flamm SD Hundley WG Marwick TH Mosca L Patel AR Quinones MA Redberg RF Taubert KA Taylor AJ Thomas GS Wenger NK;Cardiac Imaging Committee Council on Clinical Cardiology the Cardiovascular Imaging Intervention Committee Council on Cardiovascular Radiology Intervention American Heart Association 《Circulation》2005,111(5):682-696
Cardiovascular disease is the leading cause of mortality for women in the United States. Coronary heart disease, which includes coronary atherosclerotic disease, myocardial infarction, acute coronary syndromes, and angina, is the largest subset of this mortality, with >240,000 women dying annually from the disease. Atherosclerotic coronary artery disease (CAD) is the focus of this consensus statement. Research continues to report underrecognition and underdiagnosis of CAD as contributory to high mortality rates in women. Timely and accurate diagnosis can significantly reduce CAD mortality for women; indeed, once the diagnosis is made, it does appear that current treatments are equally effective at reducing risk in both women and men. As such, noninvasive diagnostic and prognostic testing offers the potential to identify women at increased CAD risk as the basis for instituting preventive and therapeutic interventions. Nevertheless, the recent evidence-based practice program report from the Agency for Healthcare Research and Quality noted the paucity of women enrolled in diagnostic research studies. Consequently, much of the evidence supporting contemporary recommendations for noninvasive diagnostic studies in women is extrapolated from studies conducted predominantly in cohorts of middle-aged men. The majority of diagnostic and prognostic evidence in cardiac imaging in women and men has been derived from observational registries and referral populations that are affected by selection and other biases. Thus, a better understanding of the potential impact of sex differences on noninvasive cardiac testing in women may greatly improve clinical decision making. This consensus statement provides a synopsis of available evidence on the role of the exercise ECG and cardiac imaging modalities, both those in common use as well as developing technologies that may add clinical value to the diagnosis and risk assessment of the symptomatic and asymptomatic woman with suspected CAD. 相似文献
996.
Marrow transplantation for patients in accelerated phase of chronic myeloid leukemia 总被引:1,自引:3,他引:1
Clift RA; Buckner CD; Thomas ED; Bryant E; Anasetti C; Bensinger WI; Bowden R; Deeg HJ; Doney KC; Fisher LD 《Blood》1994,84(12):4368-4373
The records were reviewed of 58 patients receiving transplants in Seattle with unmanipulated marrow from HLA-identical siblings during the accelerated phase (AP) of chronic myeloid leukemia. Variables examined for association with survival and relapse included the interval from diagnosis to transplant, the reasons for categorization as AP, age, regimen, and cytomegalovirus serology. Four patients relapsed. The 4-year probabilities of survival, relapse-free survival, nonrelapse mortality, and relapse were 0.49, 0.43, 0.51, and 0.12, respectively. After completion of the stepwise multivariate analysis, age less than 38 years and categorization as AP solely on the basis of chromosomal abnormalities emerged as being independently significantly associated with improved survival. The 4-year probability of survival for the 16 patients categorized as AP because of chromosomal abnormalities and receiving transplant less than 1 year from diagnosis was 0.74. The low probability of relapse in these patients suggests that more aggressive preparative regimens are not indicated for patients receiving transplants in AP because of the increased risk of transplant-related mortality. 相似文献
997.
Gender, coronary artery disease, and coronary bypass surgery 总被引:4,自引:0,他引:4
N K Wenger 《Annals of internal medicine》1990,112(8):557-558
998.
Wenger U Johnsson E Bergquist H Nyman J Ejnell H Lagergren J Ruth M Lundell L 《European journal of gastroenterology & hepatology》2005,17(12):1369-1377
OBJECTIVE: To relieve dysphagia is the main goal in palliative treatment of patients with incurable cancer of the oesophagus or the gastro-oesophageal junction. The aim of this prospective, randomized multicentre study was to compare stent placement and brachytherapy regarding health economy and clinical outcomes. METHODS: Patients with incurable cancer of the oesophagus or gastro-oesophageal junction were randomized to receive a self-expandable metallic stent or 3 x 7 Gy brachytherapy. At clinical follow-up visits, dysphagia was scored and health care consumptions were recorded. Costs were based on hospital debits. Total lifetime healthcare consumption costs and costs for the initial treatments were calculated and a sensitivity analysis was conducted. RESULTS: Thirty patients were randomized to each treatment group. There was no difference in survival or complication rates between the two treatment strategies. There was a significant difference in the change of dysphagia scores between the time of inclusion and the 1-month follow-up visit, in favour of the stented group (P = 0.03). This difference had disappeared at 3 months. Median total lifetime costs were 17,690 for the stented group compared with 33 171 for the brachytherapy group (P = 0.005). This difference was due to higher costs for the initial treatment (4615 versus 23 857, P < 0.0001). Sensitivity analyses showed that the charges for a brachytherapy session had to be reduced from 6092 to 4222 (31%) to make this therapeutic concept cost-competitive. CONCLUSION: Stenting is currently more cost-effective compared with fractionated 3 x 7 Gy brachytherapy for patients with incurable cancer of the oesophagus and gastro-oesophageal junction. 相似文献
999.