首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   324185篇
  免费   29083篇
  国内免费   22891篇
耳鼻咽喉   2989篇
儿科学   3422篇
妇产科学   4925篇
基础医学   39949篇
口腔科学   5493篇
临床医学   45265篇
内科学   49705篇
皮肤病学   3082篇
神经病学   18360篇
特种医学   11978篇
外国民族医学   213篇
外科学   33214篇
综合类   49843篇
现状与发展   76篇
一般理论   20篇
预防医学   19614篇
眼科学   9572篇
药学   32815篇
  334篇
中国医学   17430篇
肿瘤学   27860篇
  2024年   1002篇
  2023年   5013篇
  2022年   13045篇
  2021年   16391篇
  2020年   12035篇
  2019年   10892篇
  2018年   11410篇
  2017年   9915篇
  2016年   9355篇
  2015年   14350篇
  2014年   17797篇
  2013年   15339篇
  2012年   22799篇
  2011年   25804篇
  2010年   15900篇
  2009年   12247篇
  2008年   17012篇
  2007年   17022篇
  2006年   17051篇
  2005年   16773篇
  2004年   10662篇
  2003年   9757篇
  2002年   8438篇
  2001年   7466篇
  2000年   8277篇
  1999年   9017篇
  1998年   5475篇
  1997年   5504篇
  1996年   4336篇
  1995年   3922篇
  1994年   3215篇
  1993年   2098篇
  1992年   2830篇
  1991年   2416篇
  1990年   2120篇
  1989年   1861篇
  1988年   1566篇
  1987年   1352篇
  1986年   1107篇
  1985年   912篇
  1984年   526篇
  1983年   373篇
  1982年   242篇
  1981年   238篇
  1980年   188篇
  1979年   221篇
  1978年   82篇
  1977年   89篇
  1974年   102篇
  1973年   83篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
51.
给药系统     
近年来,伴随着药物治疗的快速发展.以药理活性非常强的药物为代表,开发出许多用药时必须给予足够关注的药物,“用药最适化”这一概念逐渐成为人们非常关注的问题。这主要是为了实现用药时的最佳形式。尽可能地根据选择或者需要控制药物的浓度.时间模式。输送到药物的作用表达部位。实现治疗用药的安全性。但是,历来的方法却很难实现这一点,通过利用新的技术和方法调控药物在体内的动态变化,以获得最好治疗效果为中心的药物使用方法和药剂正在开发之中。这就是给药系统,使用可以表达自身概念的语言来命名。虽然都是以各种药物在体内的动态过程作为调控对象,但是还分为①controlled release(调控释放给药);②开发新的给药途径、克服药物吸收障碍;③靶向给药(targeting)等三个途径。  相似文献   
52.
Fully soluble hemostatic fiber (FHF) is made from cotton yarn through a series of chemical reactions with NaOH and chloroacetic acid. The major component of FHF is carboxymethylcellulose. FHF is a kind of biodegradation macromolecule material that can disassociate into a low-molecular-weight compound or a simple substance by hydrolytic and enzymatic courses. The purpose of the present study is to investigate the hemostatic mechanism of FHF. The study indicated that FHF can stop bleeding by physical, chemical and physiological routes. In the physical route, expansion of carboxymethylcellulose in FHF stops bleeding by forming a mechanical clog after contacting with the blood. In the chemical route, the platelets can quickly aggregate around FHF and stimulate releasing and disaggregating reactions, after contacting with the rough surface of FHF, producing thrombus and hemostasis. In the physiological route, gluey particles with negative charges can activate intrinsic coagulation systems by activating the blood coagulation factor XII after FHF dissolution.  相似文献   
53.
54.
现将我院2002-2005年收治住院的急性心肌梗死患者56例的心理干预及护理体会,报告如下:  相似文献   
55.
PURPOSE: Perineural invasion is a frequent occurrence in salivary adenoid cystic carcinoma (ACC) and may prevent complete surgical resection. Studies have indicated that nerve growth factor (NGF) and its high-affinity receptor tyrosine kinase A (TrkA) may play a role in perineural invasion in several malignancies in which perineural invasion is observed. The present study was conducted to investigate the expression of NGF and TrkA in salivary ACC and to examine the effects of NGF on adhesion, migration and invasion capacities of a salivary ACC cell line (SACC-83) in vitro. PATIENTS AND METHODS: Expression of NGF and TrkA was explored using immunohistochemistry in paraffin-embedded tissues of 32 cases of salivary ACC. The effects of NGF on in vitro adhesion, migration, and invasion capacities of the SACC-83 cell line were examined using an MTT assay and a modified Boyden chamber assay respectively. RESULTS: In ACC specimens, 31 (96.9%) and 32 (100%) tumors showed immunoreactivity for NGF and TrkA respectively. Significant correlations were found between NGF/TrkA expression levels and perineural invasion (P < .05). In cell adhesion assay, the percent adherences of SACC-83 cells co-cultured with 25 ng/ml NGF at 1.5 hours and 5, 25 ng/ml NGF at 6 hours were significantly higher than that co-cultured with 0 ng/ml NGF (P < .05). However, high concentration of NGF (500 ng/ml) resulted in a significant inhibition of invasion (P < .05). CONCLUSION: Overexpression of NGF and TrkA in human salivary ACC tissues may constitute a reason for perineural invasion in salivary ACC.  相似文献   
56.
57.
A prospective study was conducted with patients with pulmonary infections who were consecutively admitted to the three community hospitals in Benghu from July 1986 to May 1987, and to the children's hospital in Nanjing from September 1986 to January 1987. Antibodies to Lpi-8, Lm, Ld, and Lg were measured by the micro-agglutination test. During the study period, 150 adult patients (100 pairs sera) and 212 control healthy people and 110 pairs sera of childhood patients and 173 children without respiratory tract infections were investigated. The diagnosis of legionellosis was based on seroconversion (fourfold rise in titer to greater than 1:32 or static titer of greater than 1:32) and clinical and radiographic features of legionnaires' disease. About 11% legionella infection in hospitalized adult patients with pulmonary infections, and about 5.45% in children with atypical pneumonias.  相似文献   
58.
59.
四氧嘧啶诱发糖尿病大鼠血管紧张素的变化   总被引:1,自引:0,他引:1  
实验观察了四氧嘧啶诱发糖尿病大鼠连续饲养110d后体内肾素一血管紧张素系统的变化。结果表明,血浆和心脏的血管紧张素Ⅱ含量无明显变化,而肾脏的AngⅡ含量却明显低于正常对照组。另外,心脏的心钠素(ANP)含量在糖尿病大鼠与正常对照组之间无差别,血中的糖化血红蛋白含量基本无变化。上述结果表明,糖尿病大鼠早期心脏可能无明显损伤,而肾脏的肾素一血管紧张素系统活性降低。  相似文献   
60.
Ketogenic capacity of mitochondria from the remnant liver of 70% hepatectomized rats was studied in relation to mitochondrial phosphorylative activity. Ketogenic capacity increased to a maximum of 6.04 +/- 0.39 from 3.84 +/- 0.13 of control, with an enhancement of mitochondrial phosphorylative activity 6 hr after hepatectomy, and then decreased to normal levels within 24 hr. Adenylate energy charge, (ATP + 1/2ADP)/(ATP + ADP + AMP), of the remnant liver decreased to 0.825 +/- 0.006 as compared to 0.849 +/- 0.002 of control 6 hr after operation. At 12 hr, total ketone body concentrations of the arterial blood increased concomitant with a fall in ketone body ratio (acetoacetate/3-hydroxybutyrate) which reflects the decreased liver mitochondrial redox (NAD+/NADH) state. These findings suggest that an enhancement of mitochondrial fatty acid oxidation and ketogenesis occurs concomitant with an enhancement of mitochondrial phosphorylative activity in the remnant liver in response to a decreased energy charge after 70% hepatectomy.  相似文献   
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号