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41.
Quantity,quality, and functionality of peripheral blood cells derived from residual blood of different apheresis kits
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42.
Orally administered novel cyclic pentapeptide P‐317 alleviates symptoms of diarrhoea‐predominant irritable bowel syndrome
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43.
Dr. Ernesto Piccigallo MD Lennox J. Jeffers MD K. Rajender Reddy MD Maria Wanda Caldironi MD Anna Parenti MD Eugene R. Schiff MD 《Digestive diseases and sciences》1988,33(5):633-638
Summary A retrospective study of 10 cases of malignant peritoneal mesothelioma from two centers is reported. All cases were initially diagnosed between 1967 and 1986 utilizing laparoscopy and the histologic interpretation of laparoscopic biopsy samples. Subsequently, the original diagnosis was confirmed by two independent pathologists employing both histological and histochemical techniques. In five cases immunohistochemical studies were also performed. The clinical findings and course of the disease were similar to other reported series. Laparoscopic findings of mesothelioma were indistinguishible from metastatic peritoneal neoplasms. However, the presence of homogeneous spreading of nodules, plaques, or fleshy masses on both parietal and visceral peritoneum; the absence of direct or indirect signs of other abdominal neoplasms; and the absence of hepatic metastases or the possible presence of nodules or plaques on Glisson's capsule without any parenchymal involvement, when observed, allowed the laparoscopist to suspect the disease in four of 10 cases. Laparoscopy may be useful in detecting mesothelioma. The diagnosis is mainly morphological, but even morphology has its inherent limitations. Further studies are necessary to improve the diagnostic accuracy of this tumor.A part of this study was presented during the 12th International Congress of Gastroenterology and the 5th International Congress of Gastrointestinal Endoscopy in Lisbon, Portugal, September 16–22, 1984. 相似文献
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Paul A. Wanda Michael S. Fine Heidi M. Weeks Andrew M. Gross Jenny L. Macy Kurt A. Thoroughman 《Experimental brain research. Experimentelle Hirnforschung. Expérimentation cérébrale》2013,226(3):407-420
We have exposed human participants to both full-movement and pulsatile viscous force perturbations to study the effect of force duration on the incremental transformation of sensation into adaptation. Traditional views of movement biomechanics could suggest that pulsatile forces would largely be attenuated as stiffness and viscosity act as a natural low-pass filter. Sensory transduction, however, tends to react to changes in stimuli and therefore could underlie heightened sensitivity to briefer, pulsatile forces. Here, participants adapted within perturbation duration conditions in a manner proportionate to sensed force and positional errors. Across perturbation conditions, we found participants had greater adaptive sensitivity when experiencing pulsatile forces rather than full-movement forces. In a follow-up experiment, we employed error-clamped, force channel trials to determine changes in predictive force generation. We found that while participants learned to closely compensate for the amplitude and breadth of full-movement forces, they exhibited a persistent mismatch in amplitude and breadth between adapted motor output and experienced pulsatile forces. This mismatch could generate higher salience of error signals that contribute to heightened sensitivity to pulsatile forces. 相似文献
46.
Jay PortnoyGinger L. Chew ScD Wanda PhipatanakulP. Brock Williams PhD Carl GrimesKevin Kennedy MPH Elizabeth C. MatsuiJ. David Miller PhD David BernsteinJoann Blessing-Moore MD Linda CoxDavid Khan MD PhD David LangRichard Nicklas MD John OppenheimerChristopher Randolph MD Diane SchullerSheldon Spector MD Stephen A. TillesDana Wallace MD James SeltzerJames Sublett MD 《The Journal of allergy and clinical immunology》2013
47.
Satoshi Inoue Zhenyue Hao Andrew J. Elia David Cescon Lily Zhou Jennifer Silvester Bryan Snow Isaac S. Harris Masato Sasaki Wanda Y. Li Momoe Itsumi Kazuo Yamamoto Takeshi Ueda Carmen Dominguez-Brauer Chiara Gorrini Iok In Christine Chio Jillian Haight Annick You-Ten Susan McCracken Andrew Wakeham Danny Ghazarian Linda J.Z. Penn Gerry Melino Tak W. Mak 《Genes & development》2013,27(10):1101-1114
48.
Sixten Krper Bernd Jahrsdrfer Victor M. Corman Jan Pilch Patrick Wuchter Rainer Blasczyk Rebecca Müller Torsten Tonn Tamam Bakchoul Richard Schfer David Juhl Tatjana Schwarz Nina Gdecke Thomas Burkhardt Michael Schmidt Thomas Appl Hermann Eichler Harald Klüter Christian Drosten Erhard Seifried Hubert Schrezenmeier 《Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie》2021,48(3):137
BackgroundConvalescent plasma is one of the treatment options for COVID-19 which is currently being investigated in many clinical trials. Understanding of donor and product characteristics is important for optimization of convalescent plasma.MethodsPatients who had recovered from COVID-19 were recruited as donors for COVID-19 convalescent plasma (CCP) for a randomized clinical trial of CCP for treatment of severe COVID-19 (CAPSID Trial). Titers of neutralizing antibodies were measured by a plaque-reduction neutralization test (PRNT). Correlation of antibody titers with host factors and evolution of neutralizing antibody titers over time in repeat donors were analysed.ResultsA series of 144 donors (41% females, 59% males; median age 40 years) underwent 319 plasmapheresis procedures providing a median collection volume of 850 mL and a mean number of 2.7 therapeutic units per plasmapheresis. The majority of donors had a mild or moderate course of COVID-19. The titers of neutralizing antibodies varied greatly between CCP donors (from <1:20 to >1:640). Donor factors (gender, age, ABO type, body weight) did not correlate significantly with the titer of neutralizing antibodies. We observed a significant positive correlation of neutralization titers with the number of reported COVID-19 symptoms and with the time from SARS-CoV-2 diagnosis to plasmapheresis. Neutralizing antibody levels were stable or increased over time in 58% of repeat CCP donors. Mean titers of neutralizing antibodies of first donation and last donation of repeat CCP donors did not differ significantly (1:86 at first compared to 1:87 at the last donation). There was a significant correlation of neutralizing antibodies measured by PRNT and anti-SARS-CoV-2 IgG and IgA antibodies which were measured by ELISA. CCP donations with an anti-SARS-CoV-2 IgG antibody content above the 25th percentile were substantially enriched for CCP donations with higher neutralizing antibody levels.ConclusionWe demonstrate the feasibility of collection of a large number of CCP products under a harmonized protocol for a randomized clinical trial. Titers of neutralizing antibodies were stable or increased over time in a subgroup of repeat donors. A history of higher number of COVID-19 symptoms and higher levels of anti-SARS-CoV-2 IgG and IgA antibodies in immunoassays can preselect donations with higher neutralizing capacity. 相似文献
49.
Hein J. Verberne Wanda Acampa Constantinos Anagnostopoulos Jim Ballinger Frank Bengel Pieter De Bondt Ronny R. Buechel Alberto Cuocolo Berthe L. F. van Eck-Smit Albert Flotats Marcus Hacker Cecilia Hindorf Philip A. Kaufmann Oliver Lindner Michael Ljungberg Markus Lonsdale Alain Manrique David Minarik Arthur J. H. A. Scholte Riemer H. J. A. Slart Elin Trägårdh Tim C. de Wit Birger Hesse 《European journal of nuclear medicine and molecular imaging》2015,42(12):1929-1940
50.