全文获取类型
收费全文 | 604篇 |
免费 | 51篇 |
专业分类
儿科学 | 28篇 |
妇产科学 | 7篇 |
基础医学 | 60篇 |
口腔科学 | 15篇 |
临床医学 | 72篇 |
内科学 | 180篇 |
皮肤病学 | 14篇 |
神经病学 | 28篇 |
特种医学 | 134篇 |
外科学 | 18篇 |
综合类 | 13篇 |
预防医学 | 28篇 |
眼科学 | 1篇 |
药学 | 36篇 |
肿瘤学 | 21篇 |
出版年
2023年 | 1篇 |
2022年 | 5篇 |
2021年 | 10篇 |
2020年 | 1篇 |
2019年 | 4篇 |
2018年 | 11篇 |
2017年 | 8篇 |
2016年 | 11篇 |
2015年 | 13篇 |
2014年 | 12篇 |
2013年 | 30篇 |
2012年 | 21篇 |
2011年 | 14篇 |
2010年 | 26篇 |
2009年 | 34篇 |
2008年 | 22篇 |
2007年 | 16篇 |
2006年 | 15篇 |
2005年 | 16篇 |
2004年 | 12篇 |
2003年 | 10篇 |
2002年 | 6篇 |
2001年 | 8篇 |
2000年 | 9篇 |
1999年 | 12篇 |
1998年 | 32篇 |
1997年 | 30篇 |
1996年 | 36篇 |
1995年 | 24篇 |
1994年 | 26篇 |
1993年 | 24篇 |
1992年 | 5篇 |
1991年 | 6篇 |
1990年 | 4篇 |
1989年 | 17篇 |
1988年 | 12篇 |
1987年 | 13篇 |
1986年 | 9篇 |
1985年 | 10篇 |
1984年 | 6篇 |
1983年 | 6篇 |
1982年 | 8篇 |
1981年 | 10篇 |
1980年 | 3篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 13篇 |
1976年 | 8篇 |
1975年 | 11篇 |
1968年 | 2篇 |
排序方式: 共有655条查询结果,搜索用时 9 毫秒
41.
42.
In this study we investigated whether determination of the convulsion threshold by electrical stimulation of the cortex could be used as a simple test for measuring anticonvulsant drug activity in unrestrained, unanaesthetized rats. Pulse trains delivered to electrodes implanted in the frontoparietal cortex elicited convulsions, similar to those seen in the classical electroshock tests. The threshold could be determined rapidly with pulse trains which increased in strength in a ramp-shaped fashion (bipolar pulses of 2 msec, 50 pulses/sec, increment 1.3 microA/pulse). The threshold was defined as the current needed to elicit forelimb clonus. Upon repeated stimulation the threshold declined from a value of about 600 microA to about 350 microA in 20 sessions. Thereafter, continued testing did not result in considerable changes in threshold. After stabilization, the convulsion threshold could be determined repeatedly with intervals as short as 5 min. Following i.p. injection of 5 mg/kg of diazepam an elevation of the threshold of 30% was observed 0.5 h after injection. After 5 daily injections, evidence for the development of complete tolerance was obtained. After i.v. injection of 8 mg/kg oxazepam, the threshold increase reached a peak level of 75% after 20 min. The changes in threshold followed arterial blood concentration of oxazepam, which was maximally 4.8 micrograms/ml immediately after injection. The threshold returned to baseline in approximately 6 h. The results of the present study show that with our procedure anticonvulsant drug activity can be accurately, rapidly and repeatedly determined in individual animals, both in acute and chronic experiments. 相似文献
43.
44.
The cisterna magna is effaced in association with myelomeningocele. The authors retrospectively investigated the size of the fetal cisterna magna as a predictor of fetal myelomeningocele in 67 pregnant women (17-38 menstrual weeks) referred for prenatal sonography because of an elevated serum alpha-fetoprotein level (n = 61) or a suspicion of fetal ventriculomegaly on previously obtained sonograms (n = 6). Twenty fetuses had myelomeningocele, 14 had isolated ventriculomegaly, and 33 were normal. A normal-sized cisterna magna (range, 4-9 mm in depth) was present in all normal fetuses. In 19 of 20 fetuses with myelomeningocele, the views of the posterior fossa were adequate, and in each of these the cisterna magna was effaced (n = 18) or very small (n = 1). The cisterna magna was effaced in five of 13 (38%) fetuses with isolated ventriculomegaly in whom the posterior fossa was adequately imaged. Although effacement of the cisterna magna is a nonspecific finding, the high negative predictive value of this sign is useful during routine screening of the fetal neural axis. 相似文献
45.
46.
47.
JJ Korelitz ; AE Williams ; MP Busch ; TF Zuck ; HE Ownby ; LJ Matijas ; DJ Wright 《Transfusion》1994,34(10):870-876
BACKGROUND: Most blood centers utilize a confidential unit exclusion (CUE) process, intended to reduce the risk of transfusion-associated infectious diseases by allowing high-risk donors confidentially to exclude their blood from use for transfusion. The effectiveness of this method remains controversial. STUDY DESIGN AND METHODS: Confirmatory or supplemental test results for antibodies to human immunodeficiency virus, human T-lymphotropic virus type I, and hepatitis C virus, as well as hepatitis B surface antigen and syphilis and screening test results for antibodies to hepatitis B core (antigen) and alanine aminotransferase levels were obtained for approximately 1.8 million units donated during 1991 and 1992 at five blood centers within the United States. The prevalences of these infectious disease markers in units that the donors confidentially excluded (CUE+) and units that the donors did not exclude (CUE-) were calculated and examined within demographic subgroups. RESULTS: Units that were CUE+ were 8 to 41 times more likely to be seropositive for antibodies to human immunodeficiency virus and hepatitis C virus, hepatitis B surface antigen, and syphilis and three to four times more likely to react for antibody to hepatitis B core (antigen) or to have elevated alanine aminotransferase levels than units that were CUE- (p < 0.001). The positive predictive value of CUE (the percentage of CUE+ units that were confirmed seropositive for any marker) was 3.5 percent, and the sensitivity of CUE (the percentage of confirmed-seropositive units that were CUE+) was 2.3 percent. CONCLUSION: The current CUE process has low sensitivity and apparently low positive predictive value, and in many cases, it appeared that donors misunderstood it. Yet, CUE was not a “random process,” as CUE+ units were more likely to be seropositive for any infectious disease marker than CUE- units. This suggests that efforts to improve the CUE system may be warranted. As risk factors for transfusion-transmitted infection become more difficult to identify by history-based screening, however, such efforts may have limited effect. 相似文献
48.
Total radical trapping antioxidant potential (TRAP) and exercise 总被引:1,自引:0,他引:1
Sharpe PC; Duly EB; MacAuley D; McCrum EE; Mulholland C; Stott G; Boreham CA; Kennedy G; Evans AE; Trinick TR 《QJM : monthly journal of the Association of Physicians》1996,89(3):223-228
The relationship between physical activity, physical fitness and total
radical trapping antioxidant potential (TRAP) was examined in the Northern
Ireland Health and Activity Survey. This was a cross-sectional population
study (n = 1600) using a two-stage probability sample of the population.
TRAP was calculated using the sum of the individual serum antioxidant
concentrations (urate, protein thiols, ascorbate, alpha tocopherol and
bilirubin) multiplied by their respective stoichiometric values. Physical
fitness was determined by estimation of VO2max by extrapolation from
submaximal oxygen uptake, and physical activity was recorded by
computer-assisted interview. Mean serum TRAP concentrations were
significantly higher in males (653 +/- 8.2 mumol/l, mean +/- SEM) compared
to females (564 +/- 8.0 mumol/l) (p < 0.0001). Both male and female
smokers had significantly lower TRAP values than non-smokers (males p <
0.0001, females p = 0.02). In females, there was a positive relationship of
TRAP with age (p < 0.001) and body mass index (p < 0.001) but a
negative relationship with physical fitness (p < 0.05). The known
beneficial effects of exercise and activity do not appear to be directly
mediated through increased antioxidant status.
相似文献
49.
50.
A Choppin I Irwin L Lach MG McDonald AE Rettie L Shao C Becker MP Palme X Paliard S Bowersox DM Dennis P Druzgala 《British journal of pharmacology》2009,158(6):1536-1547