全文获取类型
收费全文 | 8070篇 |
免费 | 421篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 118篇 |
儿科学 | 529篇 |
妇产科学 | 118篇 |
基础医学 | 977篇 |
口腔科学 | 145篇 |
临床医学 | 531篇 |
内科学 | 1491篇 |
皮肤病学 | 227篇 |
神经病学 | 547篇 |
特种医学 | 125篇 |
外科学 | 1123篇 |
综合类 | 215篇 |
一般理论 | 8篇 |
预防医学 | 503篇 |
眼科学 | 274篇 |
药学 | 932篇 |
中国医学 | 47篇 |
肿瘤学 | 596篇 |
出版年
2023年 | 41篇 |
2022年 | 154篇 |
2021年 | 306篇 |
2020年 | 176篇 |
2019年 | 226篇 |
2018年 | 272篇 |
2017年 | 189篇 |
2016年 | 235篇 |
2015年 | 265篇 |
2014年 | 352篇 |
2013年 | 397篇 |
2012年 | 622篇 |
2011年 | 609篇 |
2010年 | 373篇 |
2009年 | 270篇 |
2008年 | 493篇 |
2007年 | 441篇 |
2006年 | 432篇 |
2005年 | 378篇 |
2004年 | 389篇 |
2003年 | 297篇 |
2002年 | 239篇 |
2001年 | 143篇 |
2000年 | 133篇 |
1999年 | 117篇 |
1998年 | 79篇 |
1997年 | 50篇 |
1996年 | 44篇 |
1995年 | 39篇 |
1994年 | 30篇 |
1993年 | 37篇 |
1992年 | 68篇 |
1991年 | 56篇 |
1990年 | 40篇 |
1989年 | 69篇 |
1988年 | 50篇 |
1987年 | 28篇 |
1986年 | 33篇 |
1985年 | 29篇 |
1984年 | 27篇 |
1983年 | 44篇 |
1982年 | 15篇 |
1981年 | 19篇 |
1980年 | 22篇 |
1979年 | 25篇 |
1978年 | 16篇 |
1977年 | 15篇 |
1973年 | 19篇 |
1972年 | 14篇 |
1970年 | 13篇 |
排序方式: 共有8506条查询结果,搜索用时 31 毫秒
91.
S. C. Mishra S. K. Sardana V. S. Dave 《Indian journal of otolaryngology and head and neck surgery》1978,30(2):65-67
Abnormal vestibular responses are observed more frequently in cerebellar and Brain stem lesions than in cerebello-pontine angle tumours. The direction of spontaneous, positional, positioning nystagmus or caloric induced directional preponderance are not quite reliable in topographical localisation of these lesions. Hyperreflexia and dysarhythmia of thermally induced nystagmus are reasonably reliable evidences of affections of cerebellum or its connections. The deficiency of the fast phase of nystagmus indicates a bulbopontine lesion. 相似文献
92.
Intravenously administered oxytocin caused a dose-related fall in blood pressure of the rabbit. When oxytocin was administered in oestrogen-primed animals, the depressor response was converted to a pressor one "Oxytocin reversal". The "oxytocin reversal." was abolished after treatment with dihydroergotamine, hexamethonium or adrenalectomy. The "oxytocin reversal" did not appear in reserpinized animals. 相似文献
93.
A. Mishra 《Indian journal of otolaryngology and head and neck surgery》2003,55(3):211-212
Telemedicine is an upcoming concept in the modem world, It needs to be inculcated to improve the coordination amongst the
health care providers in order, not only to update themselves but also to provide a coordinated approach far eatering masses
in a developing country The various advantages and drawbacks are highlighted, and stress is made on starting a remote method
of tetecommunication amongst us. 相似文献
94.
Pharmacokinetics, in-situ absorption and protein binding studies of a new neuroleptic agent centbutindole in rats. 总被引:1,自引:0,他引:1
Manish Issar Shio K Singh Bhrameshwar Mishra Ram C Gupta 《European journal of pharmaceutical sciences》2003,19(2-3):105-113
The present study reports the absorption kinetics, plasma protein binding and pharmacokinetic profile of the centbutindole (I) after i.v. and oral dosing in rats. In addition, an in-situ absorption study was carried out using a closed-loop technique at pH 2.6 and 7.4. The rate of absorption at pH 2.6 was 5-fold less compared to that observed at pH 7.4. In-vitro and in-vivo protein binding (ultra filtration technique) was independent of substrate concentration over a range of 1.25-10.0 microg/ml. Pharmacokinetic parameters of I were determined in male rats after administering a single 4 mg/kg oral dose and 2 mg/kg intravenous dose. The peak serum concentration of I was found to be 50.1 ng/ml at 30 min after oral administration followed by a secondary Cmax of 43.2 ng/ml at 180 min. For the hydroxy metabolite (II), a Cmax of 6.4 ng/ml was measured at 360 min after oral administration of I. After oral dosing an irregular concentration-time profile with secondary peaks was observed for both I and II. The terminal half-lives for I and II after oral dosing were 163 and 263 min, respectively. After intravenous dosing, the levels of I decreased biexponentially with a distribution (t(1/2) alpha) and elimination (t(1/2) beta) half-lives of 5.7 and 128 min, respectively. Comparison of the AUC after oral and intravenous dosing of I indicates that only about 24% of the oral dose reaches the systemic circulation. The limited bioavailability can either be due to the poor solubility of the compound and/or extensive first pass metabolism in the gastrointestinal (GI) tract. Co-administration of polyethylene glycol (PEG) at oral dosing improves solubilization and increases bioavailability. 相似文献
95.
The present study describes the formulation and evaluation for pharmacokinetic and pharmacodynamic activity of arginine vasopressin (AVP), a nanopeptide with antidiuretic activity on being delivered by transdermal iontophoresis. Poloxamer 407 was used to form stable gels that did not reduce the release of AVP. The release rate from the gel followed Higuchi kinetics indicating that the dominant mechanism of release is diffusion. Iontophoresis alone and in combination with chemical enhancers was used to augment the transdermal permeation of AVP. The results of both pharmacokinetic and pharmacodynamic studies emphasize the dimension of 'rapid onset' achieved by iontophoresis. The correlation between pharmacokinetic data and pharmacodynamic activity was only qualitative. Histopathological studies revealed that skin toxicity caused by either iontophoresis or chemical enhancers when used alone could be reduced by using a combination of both the techniques in tandem. 相似文献
96.
Effect of iontophoresis and fatty acids on permeation of Arginine Vasopressin through rat skin 总被引:9,自引:0,他引:9
The aim of this study was to assess the effects of fatty acids and iontophoretic mode of penetration enhancement on transdermal delivery of Arginine Vasopressin (AVP). Sprague-Dawley (SD) rat skin was pretreated with fatty acids (e.g. 5% w/v, lauric acid, oleic acid, and linoleic acid in ethanol:water (EtOH:W, 2:1 system) for 2h and iontophoresis in vitro, separately or together. The results indicate that all fatty acids studied increased (P<0.05) the flux of AVP in comparison to control (not pretreated with enhancer) and their effectiveness in flux enhancement was comparable. Further, oleic acid in combination with iontophoresis significantly increased the permeation of AVP both in comparison to pretreatment with fatty acids and iontophoresis alone. However, iontophoresis did not further increase the permeation of AVP through linoleic acid pretreated skin. Fourier transform infrared (FT-IR) spectroscopic studies revealed that EtOH:W (2:1) system is not effective in lipid extraction. The shift to higher wavenumbers of the symmetric and asymmetric stretching peaks at 2850 and 2920cm(-1) revealed that at the concentration used, oleic acid and linoleic acid caused fluidization of stratum corneum (SC) lipids. This study provides direct evidence that oleic acid in EtOH:W (2:1) system causes disruption of the SC lipid lamellae and that a combination of oleic acid with iontophoresis further enhances the effects of oleic acid in a synergistic manner. 相似文献
97.
Treatment of chronic myelogenous leukemia with a specific inhibitor of the Bcr/Abl tyrosine kinase, imatinib, has shown great promise. However, acute lymphoblastic leukemias that express Bcr/Abl only transiently respond to imatinib. Therefore, alternative treatments for this type of leukemia are urgently needed. Here, we examined the activity of the farnesyltransferase inhibitor SCH66336 as a single chemotherapeutic agent in a nude mouse model representative of very advanced stage Bcr/Abl P190-positive lymphoblastic leukemia/lymphoma. Our results show that oral administration of the inhibitor was able to significantly increase the survival of these mice compared to controls treated with vehicle (P<0.005), and caused marked regression of the tumor burden in the treated mice. Upon prolonged treatment, lymphomas re-emerged and a subset of cells from two of such lymphomas tested was able to survive in the presence of increased concentrations of SCH66336. The same cells, however, remained sensitive towards imatinib. A combination of the two drugs, preceded by a therapy to reduce the initial tumor burden, could be very effective in the treatment of Ph-positive ALL. We conclude that SCH66336, on its own, is remarkably effective in eradicating large numbers of lymphoblastic lymphoma cells and causing visible reduction in tumor size, with minimal toxicity. 相似文献
98.
S. K. Mishra P. K. Dash P. Keshri S. Jena S. Sur 《Indian journal of otolaryngology and head and neck surgery》2003,55(1):28-29
A case of Myxoma involving left Maxilla, presenting as swelling of left side of face and Oral cavity with bilateral nasal obstruction is reported. 相似文献
99.
100.