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排序方式: 共有374条查询结果,搜索用时 15 毫秒
41.
Maria Siebes Christina Kolyva Bart-Jan Verhoeff Jan J. Piek Jos A. Spaan 《Medical & biological engineering & computing》2009,47(2):233-239
Wave intensity analysis (WIA) is beginning to be applied to the coronary circulation both to better understand coronary physiology
and as a diagnostic tool. Separation of wave intensity (WI) into forward and backward traveling components requires knowledge
of pulse wave velocity at the point of measurement, which at present cannot accurately be determined in human coronary vessels.
This prompted us to study the sensitivity of wave separation to variations in wave speed. An estimate of wave speed (SPc)
was calculated based on measured distal intracoronary pressure and Doppler velocity in normal and diseased coronary vessels
of patients during hyperemia. Changes of the area under separated WI waveforms were determined for a range of wave speeds
from 25 to 200% of the calculated value. Variations in wave speed between half to twice the calculated value did not substantially
alter separated WI. In conclusion, although SPc lacks accuracy in determining local coronary wave speed it is within limits
still applicable for wave separation in coronary WIA. 相似文献
42.
Fassaert T de Wit MA Tuinebreijer WC Verhoeff AP Beekman AT Dekker J 《Social psychiatry and psychiatric epidemiology》2009,44(3):208-216
Background There is a supposed higher prevalence of common mental disorders among many migrant groups. At the same time, problems are
reported regarding underutilisation of mental health services by migrants. Since perceived need for care is a powerful predictor
of actual care utilisation, we aimed to study the hypothesis that, given the same level of mental morbidity, non-Western migrants
would perceive less need for mental health care than ethnic Dutch residents. Additionally, we studied the extent to which
needs are met in both groups, as well as several possible barriers to care.
Methods A cross-sectional study with data from the 2004/2005 Amsterdam Health Monitor. Data were complete from 626 ethnic Dutch and
non-Western (Turkish and Moroccan) labour migrants. Respondents participated in a structured interview in their own language,
which included the perceived need for care questionnaire (PNCQ) and the composite international diagnostic interview (CIDI)
version 2.1 for anxiety and depressive disorders.
Results Perceived need was much higher among Turkish migrants. Among Moroccans the perceived need was comparable to ethnic Dutch.
Turkish migrants also reported that needs were met less often than ethnic Dutch. Differences were explained by a higher prevalence
of common mental disorders and higher symptom levels among Turkish. When differences in mental morbidity were taken into account,
Moroccans perceived less need for information, drugs, referral to specialised mental health care, or for counselling. The
most important barrier to care in all ethnic groups was the preference to solve the problem on one’s own.
Conclusion In case of similar mental morbidity, perceived need for care was lower than among ethnic Dutch. The results did not support
the hypothesis that in case of similar mental distress, needs of migrants were less often met than needs of ethnic Dutch. 相似文献
43.
Donker M Van Furth WR Mulder-Van Der Kracht S Hovinga KE Verhoeff JJ Stalpers LJ van Bree C 《Oncology reports》2007,18(3):709-714
Glioblastoma multiforme (GBM) is a radioresistant tumor. Tumor neoangiogenesis is an important mechanism for tumor sustenance. Angiogenesis is primarily mediated by vascular endothelial growth factor (VEGF), and earlier studies have suggested that VEGF protects human umbilical vein endothelial cells (HUVECs) against high doses of radiation. We tried to extend these findings to other endothelial cell lines and clinically relevant irradiation doses. Therefore, four different endothelial cell lines (HUVEC-C, primary HUVEC-P, an immortalized HUVEC cell line: EC-RF24, and bovine retina endothelial cells: BREC) were cultured without or with recombinant human VEGF165 (rhVEGF165). Cells were irradiated with gamma-rays from a 137Cs-source. Radiosensitivity was determined by proliferation or clonogenic assay. Apoptosis was assayed by flow cytometric determination of the sub-G1 population or by counting nuclear fragmentation. We found that the biologically active rhVEGF165 was able to improve clonogenic survival of HUVEC-C after 2 and 5 Gy. However, rhVEGF165 could not significantly alter the radiosensitivity of all cell lines studied in proliferation assays. rhVEGF165 only slightly reduced apoptosis in HUVEC-C after 3 Gy. In conclusion, the radioprotective effect from rhVEGF165 was found on different endothelial cell lines after clinically relevant radiation doses was negligible. We therefore hypothesize that the high VEGF-levels found in GBM in vivo do not reduce the radiosensitivity of endothelial cells, which is thought to contribute to the strong radioresistance of the tumor vasculature. 相似文献
44.
Adenylate cyclase and guanylate cyclase activity in normal and leukemic human lymphocytes 总被引:1,自引:0,他引:1
Adenylate cyclase (AC) and guanylate cyclase (GC) activities were studied in normal B-enriched and T-enriched lymphocytes, in lymphocytes of children with acute lymphocytic leukemia (ALL), and in lymphocytes of adults with chronic lymphocytic leukemia (CLL). AC activity was greater in normal B than T lymphocytes (215 pmole/min/mg protein versus 80 pmole in the membrane-enriched fraction) and i both increased greatly after stimulation with isoproterenol and more so with prostaglandins E and F2 alpha. In leukemic lymphocytes, AC showed depressed activity (20 pmole in ALL cells and 55 pmole in CLL cells) and was less sensitive to hormonal stimulation: this loss of sensitivity occurred to a greater extent in ALL than in CLL lymphocytes. GC activity was greater in normal T than B cells (in membrane-enriched fraction: 10.2 pmole versus 5.3 pmole). It increased little with isoproterenol and prostaglandins stimulation, and much more with sodium azide and dehydroascorbic acid stimulation. GC activity was increased in both types of leukemic lymphocytes (23 pmole for ALL cells and 18 pmole for CLL cells) and was insensitive to stimulation. Possible derangement of cyclase and cyclic nucleotide regulation in leukemic cells is suggested. 相似文献
45.
Tsang Vionna M. W. Verlinden Eva van Duin Esther M. Twisk Jos W. R. Brilleslijper-Kater Sonja N. Gigengack Maj R. Verhoeff Arnoud P. Lindauer Ramón J. L. 《Child psychiatry and human development》2021,52(5):891-902
Child Psychiatry & Human Development - Longitudinal research of CSA in infancy and early childhood is scarce. The current study examined the long-term course of psychological outcomes (PTSD,... 相似文献
46.
Kirsten M van Steenbergen-Weijenburg Lars de Vroege Robert R Ploeger Jan W Brals Martijn G Vloedbeld Thiemo F Veneman Leona Hakkaart-van Roijen Frans FH Rutten Aartjan TF Beekman Christina M van der Feltz-Cornelis 《BMC health services research》2010,10(1):235
Background
For the treatment of depression in diabetes patients, it is important that depression is recognized at an early stage. A screening method for depression is the patient health questionnaire (PHQ-9). The aim of this study is to validate the 9-item Patient Health Questionnaire (PHQ-9) as a screening instrument for depression in diabetes patients in outpatient clinics. 相似文献47.
Informal caregivers’ views on the division of responsibilities between themselves and professionals: A scoping review 下载免费PDF全文
Yvette Wittenberg MSc Rick Kwekkeboom PhD Janneke Staaks MSc Arnoud Verhoeff PhD Alice de Boer PhD 《Health & social care in the community》2018,26(4):e460-e473
This scoping review focuses on the views of informal caregivers regarding the division of care responsibilities between citizens, governments and professionals and the question of to what extent professionals take these views into account during collaboration with them. In Europe, the normative discourse on informal care has changed. Retreating governments and decreasing residential care increase the need to enhance the collaboration between informal caregivers and professionals. Professionals are assumed to adequately address the needs and wishes of informal caregivers, but little is known about informal caregivers’ views on the division of care responsibilities. We performed a scoping review and searched for relevant studies published between 2000 and September 1, 2016 in seven databases. Thirteen papers were included, all published in Western countries. Most included papers described research with a qualitative research design. Based on the opinion of informal caregivers, we conclude that professionals do not seem to explicitly take into account the views of informal caregivers about the division of responsibilities during their collaboration with them. Roles of the informal caregivers and professionals are not always discussed and the division of responsibilities sometimes seems unclear. Acknowledging the role and expertise of informal caregivers seems to facilitate good collaboration, as well as attitudes such as professionals being open and honest, proactive and compassionate. Inflexible structures and services hinder good collaboration. Asking informal caregivers what their opinion is about the division of responsibilities could improve clarity about the care that is given by both informal caregivers and professionals and could improve their collaboration. Educational programs in social work, health and allied health professions should put more emphasis on this specific characteristic of collaboration. 相似文献
48.
AA Lapillonne FH Glorieux BL Salle PM Braillon M Chambon J Rigo G Putet J Senterre 《Acta paediatrica (Oslo, Norway : 1992)》1994,83(S405):117-122
Fat and mineral metabolic balance studies were performed in 25 normal very low-birth-weight infants ( 1500 g at birth) fed either pooled pasteurized human milk supplemented with calcium, phosphorus and magnesium, or a preterm formula. Calcium, phosphorus and magnesium intake were similar in both groups and averaged 100mg/kg/day, 72 mg/kg/day and 8 mg/kg/day, respectively. Calcium and phosphorus retention was higher in the subjects fed fortified human milk than in those receiving a preterm formula (65±14 and 62±9mg/kg/day versus 55±12 and 47±7mg/kg/day respectively). The difference was only significant for phosphorus. Magnesium retention was similar in the two groups and averaged 3 mg/kg/day. Fat intake and absorption was significantly higher in the preterm formula fed group than in the one fed fortified human milk (5.5±0.4 g/kg/day and 88±4% versus 4.2±1 g/kg/day, 79±6% respectively). Assessment of the whole body bone mineral content by dual energy X-ray absorptiometry was performed at 3 and 6 months of age in another group of 25 low-birth-weight infants fed either fortified human milk or a preterm formula. Whole body bone mineral content (BMCt) was low (43.3±30.8 g of hydroxyapatite) at 3 months of age (theoretical term) compared to normal full-term newborns at birth. There was no significant influence of the diet. At 6 months of age, BMCt reached 168.6±36.6g, a value similar to that of full-term newborns, with no significant difference between the two regimen groups. The deficit in the 12 subjects who had a BMCt under 30 g at 3 months of age had been corrected at age 6 months. Premature babies fed a pooled pasteurized human milk enriched with calcium, phosphorus and magnesium favored a better retention of calcium and phosphorus. However, no significant influence of the two diets studied was observed on the gain in BMCt over the first 6 months of life. 相似文献
49.
J. H. van Wijnen A. P. Verhoeff D. K. F. Mulder-Folkerts H. J. H. Brachel C. Schou 《Allergy》1997,52(4):460-464
The cockroach allergen (Bla g 1) content was determined in the floor dust of 46 homes with recent cockroach extermination in Amsterdam, The Netherlands. IgE antibodies to Blattella germanica , house-dust mite, cat dander, dog dander, and a mixture of molds were determined in venous blood samples of 46 children (4-12 years) and one of their biologic parents (24-54 years). Specific IgE to cockroach was also determined in a sample of the general population studied in a previous case-control study, one group ( n =20) with and three groups ( n =76) without history of cockroach infestation of the home. Cockroach allergen was detected in floor dust from 44% of the homes, with levels up to 3899 ng Bla g 1/g. Seven of the 46 adults and only one of the 46 children studied had positive RAST to cockroach. Geometric mean cockroach allergen concentrations in living room and master bedroom of sensitized adults were similar to those of nonsensitized adults. In the groups of children without a history of cockroach infestation of the home, positive RAST against cockroach was observed in 16% of the children with respiratory symptoms, in 4% of the children without respiratory symptoms, and in 48% of the children with two or more positive RAST to other allergens. Of the 18 children with positive RAST against cockroach, only one had a history of cockroach infestation of the home and 16 (89%) had also positive RAST against house-dust mite. 相似文献
50.