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61.
62.
Kantarjian HM; Barlogie B; Pershouse M; Swartzendruber D; Keating MJ; McCredie KB; Freireich EJ 《Blood》1985,66(1):39-46
In an effort to develop a new tumor marker suitable for flow cytometric analysis, we examined the value of double-stranded ribonucleic acid (ds- RNA) measurements using propidium iodide after DN'ase treatment. Cellular ds-RNA content was evaluated both in experimental cell lines and in clinical specimens. Higher levels of ds-RNA were present in tumor cells as compared with normal cells. In tumor cells, fluorescence was intensely localized in the nucleolus and was more diffuse in the cytoplasm. Change of less than 10% in the ds-RNA levels was observed in cell lines as a function of cytokinetic determinants such as cycle phase, culture age, and cycle traverse rate. Tumor differentiation by dimethylsulfoxide resulted in a significant decrease in cellular ds-RNA content. For quantitative comparison of clinical material, a ds-RNA excess was defined in relationship to normal peripheral blood lymphocytes. ds-RNA excess greater than 30% was observed in only one of 34 normal tissues (3%) as compared with 124 of 201 neoplastic tissue samples (62%). This incidence was higher in patients with acute leukemia (76%), high-grade and intermediate-grade lymphoma (75%), and high tumor stage myeloma (83%), as compared with chronic leukemia (20%), low-grade lymphoma (25%), and intermediate or low tumor mass myeloma (43%). Prognostically, a high pretreatment ds-RNA excess in myeloma was associated with a lower remission rate. The persistence of ds-RNA excess in the bone marrow of patients with acute myelogenous leukemia in remission predicted for a shorter remission duration (seven v 22 months; P = .05). We conclude that ds-RNA excess, as readily measured objectively and quantitatively by flow cytometry, may have important diagnostic and prognostic implications for the management of patients with malignant disease. 相似文献
63.
64.
KB Ferguson R Bharadwaj A MacDonald B Syme AM Bal 《Annals of the Royal College of Surgeons of England》2014,96(2):e1-e4
Pasteurella multocida is a rare cause of prosthetic joint infection. This infection generally follows significant animal contact, usually licks and scratches. We report a case of P multocida infection that was treated with linezolid with salvage of the implant. Linezolid is generally active against Gram-positive organisms only with the exception of Pasteurella, which is Gram-negative. We extensively review the previous reported cases of implant infection with P multocida. 相似文献
65.
66.
Deborah KB Runyoro Mecky IN Matee Olipa D Ngassapa Cosam C Joseph Zakaria H Mbwambo 《BMC complementary and alternative medicine》2006,6(1):11-10
Background
Candida albicans has become resistant to the already limited, toxic and expensive anti-Candida agents available in the market. These factors necessitate the search for new anti-fungal agents. 相似文献67.
The prevalence of obesity is increasing in America, but its impact on morbidity relative to other health risks is unclear. This paper compares the effects of overweight, poverty, smoking and problem drinking on occurrence of chronic conditions and health-related quality of life. The data were collected from a nationally representative household telephone survey of 9585 adults fielded in 1998, using self-reported measures of height and weight, poverty, smoking status, problem drinking, chronic conditions and SF-12 global scales. Regression analyses were used to estimate effects of health risk factors on morbidity. Thirty-six percent of adults are overweight but not obese (25< or =BMI<30) and another 23% are obese (BMI> or =30). Controlling for demographics, obesity is associated with more chronic conditions and worse physical health-related quality of life (P<0.01). Smoking history and poverty predict having chronic conditions, but their effect sizes are significantly smaller. Even after controlling for chronic conditions, obesity predicts physical health-related quality of life, in that case with an effect size similar to poverty. The effect of problem drinking is always smaller. Obesity is highly prevalent and associated with at least as much morbidity as are poverty, smoking and problem drinking. Nevertheless, the latter have achieved more consistent attention in recent decades in clinical practice and public health policy. 相似文献
68.
HLA DRB1* typing and cartilage oligomeric matrix protein (COMP) as predictors of joint destruction in recent-onset rheumatoid arthritis 总被引:2,自引:0,他引:2
The carriage of a characteristic sequence of amino acids at position 67- 72
in the third hypervariable region of the HLA DRB1 chain has been linked to
susceptibility to rheumatoid arthritis (RA). Whether this epitope is also a
predictor of more severe disease remains controversial. Cartilage
oligomeric matrix protein (COMP) is a protein, the serum levels of which
have been found to correlate with large joint destructive disease in
previous work. In this paper, we compare DRB1* typing and serum COMP levels
in a prospectively observed group of RA patients with or without early hip
joint destruction. The COMP levels at study inclusion, median 11 months
from onset of symptoms, were significantly higher in the patients with
early hip joint destruction compared to the patients in the more benign
group. There was no difference in the number of disease
susceptibility-related epitopes between the groups. DRB1*04, in contrast,
was found among 8/8 patients with hip destruction, but also in 5/8 more
benign cases. We conclude that in this type of RA patient, COMP serum
levels are more informative predictors of aggressive disease than HLA DRB1*
typing.
相似文献
69.
Linkage analysis of candidate regions for coeliac disease genes 总被引:5,自引:0,他引:5
Houlston RS; Tomlinson IP; Ford D; Seal S; Marossy AM; Ferguson A; Holmes GK; Hosie KB; Howdle PD; Jewell DP; Godkin A; Kerr GD; Kumar P; Logan RF; Love AH; Johnston S; Marsh MN; Mitton S; O'Donoghue D; Roberts A; Walker-Smith JA; Stratton MF 《Human molecular genetics》1997,6(8):1335-1339
A strong HLA association is seen in coeliac disease [specifically to the
DQ(alpha1*0501,beta1*0201 heterodimer], but this cannot entirely account
for the increased risk seen in relatives of affected cases. One or more
genes at HLA-unlinked loci also predispose to coeliac disease and are
probably stronger determinants of disease susceptibility than HLA. A recent
study has proposed a number of candidate regions on chromosomes 6p23
(distinct from HLA), 6p12, 3q27, 5q33.3, 7q31.3, 11p11, 15q26, 19p13.3,
19q13.1, 19q13.4 and 22cen for the location of a non-HLA linked
susceptibility gene. We have examined these regions in 28 coeliac disease
families by linkage analysis. There was excess sharing of chromosome 6p
markers, but no support for a predisposition locus telomeric to HLA. No
significant evidence in favour of linkage to coeliac disease was obtained
for chromosomes 3q27, 5q33.3, 7q31.3, 11p11, 19p13.3, 19q13.1, 19q13.4 or
22cen. There was, however, excess sharing close to D15S642. The maximum
non-parametric linkage score was 1.99 (P = 0.03). Although the evidence for
linkage of coeliac disease to chromosome 15q26 is not strong, the well
established association between coeliac disease and insulin dependent
diabetes mellitus, together with the mapping of an IDDM susceptibility
locus (IDDM3) to chromosome 15q26, provide indirect support for this as a
candidate locus conferring susceptibility to coeliac disease in some
families.
相似文献
70.
A Basit S Nair KB Chakraborthy BB Darshan A Kamath 《The Australasian medical journal》2012,5(3):163-167