全文获取类型
收费全文 | 230篇 |
免费 | 9篇 |
专业分类
儿科学 | 15篇 |
妇产科学 | 12篇 |
基础医学 | 33篇 |
口腔科学 | 3篇 |
临床医学 | 21篇 |
内科学 | 38篇 |
神经病学 | 4篇 |
特种医学 | 6篇 |
外科学 | 81篇 |
预防医学 | 7篇 |
眼科学 | 3篇 |
药学 | 7篇 |
中国医学 | 1篇 |
肿瘤学 | 8篇 |
出版年
2023年 | 3篇 |
2022年 | 2篇 |
2021年 | 3篇 |
2020年 | 3篇 |
2019年 | 4篇 |
2018年 | 3篇 |
2017年 | 3篇 |
2016年 | 3篇 |
2015年 | 3篇 |
2014年 | 1篇 |
2013年 | 5篇 |
2012年 | 19篇 |
2011年 | 12篇 |
2010年 | 12篇 |
2009年 | 9篇 |
2008年 | 20篇 |
2007年 | 24篇 |
2006年 | 14篇 |
2005年 | 24篇 |
2004年 | 18篇 |
2003年 | 14篇 |
2002年 | 7篇 |
2001年 | 2篇 |
2000年 | 3篇 |
1998年 | 1篇 |
1996年 | 1篇 |
1991年 | 3篇 |
1990年 | 2篇 |
1988年 | 1篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 2篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1976年 | 3篇 |
1970年 | 2篇 |
1966年 | 1篇 |
1927年 | 1篇 |
1909年 | 1篇 |
排序方式: 共有239条查询结果,搜索用时 15 毫秒
231.
PURPOSE: Despite the concept that the spongy urethra is a unique entity clinical evidence suggests the existence of segmental structural differences. The spongy urethra has a vascular nature, its cells may express different phenotypes and the extracellular matrix that they synthesize should reflect these differences. Glycosaminoglycans are components of the extracellular matrix that have key roles in the normal physiology and pathology of several tissues. Although total collagen content of the urethra was determined, we also analyzed urethral glycosaminoglycans (GAGs). MATERIALS AND METHODS: Fresh, macroscopically normal cadaveric urethral samples were obtained from 15 men who died at a mean age of 25.4 years. The urethra was divided into glanular, penile and bulbar segments, which were then analyzed separately. Total GAG concentration was assessed by hexuronic acid assay and expressed as microg. hexuronic acid per mg. dry tissue, while the proportions of sulfated GAGs were determined by agarose gel electrophoresis. Hyaluronan concentration was determined by ion exchange chromatography and total tissue collagen was estimated as hydroxyproline content. RESULTS: Total GAG concentration was heterogeneous along the spongy urethra (p <0.001). Mean values plus or minus standard deviation in the glanular, penile and bulbar segments were 2.53 +/- 0.42, 2.11 +/- 0.47 and 1.47 +/- 0.4 microg./mg., respectively. The most predominant GAG was hyaluronan and its highest mean concentration of 50.1% +/- 3.7% was found in the glanular urethra. The most predominant sulfated GAG in the male urethra was dermatan sulfate, followed by chondroitin sulfate and heparan sulfate. Total collagen content and the GAG-to-collagen ratio varied along the spongy urethra and were lowest in the bulbar segment. CONCLUSIONS: The extracellular matrix of the human spongy urethra shows regional differences, as evidenced by biochemical analysis of GAG and collagen. This heterogeneity implies functional adaptations in the various segments and may affect the physiology and segmental incidence of urethral diseases. 相似文献
232.
233.
234.
Hammarberg KM Becker M Svensson J Skoog V Svensson H 《Journal of plastic surgery and hand surgery》2012,46(3-4):200-203
Abstract Malm? and Uppsala have been regional centres for the treatment of cleft lip and palate since the beginning of the 1950s. We have about 80 new cases every year and most patients have conventional oronasal clefts, either cleft lip and palate or isolated cleft palate. During a 10-year period we have come across four patients who have had varying degrees of midface dysplasia combined with intracranial anomalies. One child died at an early age, but the other three children were given medical substitution of hypopituitarism and have had their clefts reconstructed. 相似文献
235.
236.
Christophe Henri Valdemar Duez Mads Qvist Ebbesen Krisztina Benedek Martin Fabricius Mary Doreen Atkins Sandor Beniczky Troels W. Kjaer Hans Kirkegaard Birger Johnsen 《Clinical neurophysiology》2018,129(4):724-730
Objective
To assess inter-rater agreement on EEG-reactivity (EEG-R) in comatose patients and compare it with a quantitative method (QEEG-R).Methods
Six 30-s stimulation epochs (noxious, visual and auditory) were performed during EEG on 19 neurosurgical and 11 cardiac arrest patients. Six experts analysed EEGs for reactivity using their habitual methods. QEEG-R was defined as present if ≥2/6 epochs were reactive (stimulation/rest power ratio exceeding noise level). Three-months patient outcome was assessed by the Cerebral Performance Category Score (CPC) dichotomized in good (1–2) or poor (3–5).Results
Agreement among experts on overall EEG-R varied from 53% to 83% (κ: 0.05–0.64) and reached 100% (κ: 1) between two QEEG-R calculators. For the experts, absence of EEG-R yielded sensitivities for poor outcome between 40–85% and specificities between 20–90%, for QEEG-R sensitivity was 40% (CI: 23–68%) and specificity 100% (CI: 69–100%).Conclusions
There is a large inter-rater variation among experts on EEG-R assessment in comatose patients. QEEG-R is a promising objective prognostic parameter with low inter-rater variation and a high specificity for prediction of poor outcome.Significance
Clinicians should be cautious when using the traditional, qualitative method, in particular in end-of-life decisions. Implementation of the quantitative method in clinical practice may improve reliability of reactivity assessments. 相似文献237.
Elaine Y. L. Chung Giulio Sartori Maurilio Ponzoni Luciano Cascione Valdemar Priebe Zijun Y. Xu-Monette Xiaosheng Fang Mingzhi Zhang Carlo Visco Alexandar Tzankov Andrea Rinaldi Jacopo Sgrignani Emanuele Zucca Davide Rossi Andrea Cavalli Giorgio Inghirami David W. Scott Ken H. Young Francesco Bertoni 《British journal of haematology》2023,203(2):244-254
238.
Jessyca Aparecida Paes Dutra Sarah Canal Maximino Rita de Cássia Ribeiro Gonçalves Pedro Alves Bezerra Morais William Cezar de Lima Silva Ricardo Pereira Rodrigues Álvaro Cunha Neto Valdemar Lacerda Júnior Warley de Souza Borges Rodrigo Rezende Kitagawa 《Chemical biology & drug design》2023,101(2):350-363
The high morbidity and mortality rates of Candida infections, especially among immunocompromised patients, are related to the increased resistance rate of these species and the limited therapeutic arsenal. In this context, we evaluated the anti-Candida potential and the cytotoxic profile of eugenol derivatives. Anti-Candida activity was evaluated on C. albicans and C. parapsilosis strains by minimum inhibitory concentration (MIC), scanning electron microscopy (SEM), and molecular docking calculations at the site of the enzyme lanosterol-14-α-demethylase active site, responsible for ergosterol formation. The cytotoxic profile was evaluated in HepG2 cells, in the presence and absence of the metabolizing system (S9 system). The results indicated compounds 1b and 1d as the most active ones. The compounds have anti-Candida activity against both strains with MIC ranging from 50 to 100 μg ml−1. SEM analyses of 1b and 1d indicated changes in the envelope architecture of both C. albicans and C. parapsilosis like the ones of eugenol and fluconazole, respectively. Docking results of the evaluated compounds indicated a similar binding pattern of fluconazole and posaconazole at the lanosterol-14-α-demethylase binding site. In the presence of the S9 system, compound 1b showed the same cytotoxicity profile as fluconazole (1.08 times) and compound 1d had 1.23 times increase in cytotoxicity. Eugenol and other evaluated compounds showed a significant increase in cytotoxicity. Our results suggest compound 1b as a promising starting point candidate to be used in the design of new anti-Candida agent prototypes. 相似文献
239.
Ingrid K. Hals PhD Chandima Balasuriya MD Rosaura Casas PhD Johnny Ludvigsson MD Anneli Björklund MD Valdemar Grill MD 《Diabetes, obesity & metabolism》2023,25(11):3400-3409