全文获取类型
收费全文 | 218篇 |
免费 | 17篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 5篇 |
基础医学 | 55篇 |
临床医学 | 24篇 |
内科学 | 27篇 |
皮肤病学 | 3篇 |
神经病学 | 20篇 |
特种医学 | 20篇 |
外科学 | 17篇 |
综合类 | 7篇 |
预防医学 | 43篇 |
药学 | 9篇 |
肿瘤学 | 4篇 |
出版年
2022年 | 4篇 |
2021年 | 4篇 |
2020年 | 5篇 |
2019年 | 7篇 |
2018年 | 9篇 |
2017年 | 2篇 |
2016年 | 8篇 |
2015年 | 5篇 |
2014年 | 5篇 |
2013年 | 11篇 |
2012年 | 14篇 |
2011年 | 13篇 |
2010年 | 10篇 |
2009年 | 11篇 |
2008年 | 11篇 |
2007年 | 14篇 |
2006年 | 11篇 |
2005年 | 18篇 |
2004年 | 10篇 |
2003年 | 9篇 |
2002年 | 17篇 |
2001年 | 7篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 3篇 |
1996年 | 3篇 |
1995年 | 1篇 |
1993年 | 2篇 |
1992年 | 2篇 |
1991年 | 2篇 |
1990年 | 4篇 |
1989年 | 1篇 |
1987年 | 1篇 |
1979年 | 1篇 |
排序方式: 共有235条查询结果,搜索用时 31 毫秒
91.
92.
Mahmoud?ZaqoutEmail authorView authors OrcID profile Nathalie?Michels Wolfgang?Ahrens Claudia?B?rnhorst Dénes?Molnár Luis?A.?Moreno Gabriele?Eiben Alfonso?Siani Stalo?Papoutsou Toomas?Veidebaum Stefaan?De?Henauw IDEFICS consortium 《European journal of nutrition》2018,57(2):545-555
Purpose
Exposure to breastfeeding improves the survival, health, and development of children; therefore, breast milk is recommended as the exclusive nutrient source for feeding term infants during the first 6 months. This cross-sectional study aimed to determine the possible association between exposure to exclusive breastfeeding and physical fitness performance in children and, if so, whether this association is influenced by the breastfeeding duration.Methods
A total of 2853 (52.3 % girls) European children from the IDEFICS study aged 6–11 years with complete data on physical fitness (cardiorespiratory fitness, muscular strength, flexibility, balance, speed) and exclusive breastfeeding duration (never, 1–3, 4–6, 7–12 months) were included in the present study. Multivariate and mixed linear regression models were estimated and adjusted for sex, age, birth weight, diet, physical activity, body mass index, and parental factors (age, body mass index, educational attainment).Results
We found a positive association between exclusive breastfeeding and lower-body explosive strength (β = 0.034) as well as flexibility (β = 0.028). We also found a positive association between breastfeeding and balance in boys (β = 0.039), while this association was negative in girls (β = ?0.029). To improve lower-body explosive strength, 1–3 months of exclusive breastfeeding were enough; a longer duration did not lead to increasing benefit. In contrast, 4–6 months of breastfeeding were necessary to have any benefit on flexibility or balance, although this became nonsignificant after adjustment for body mass index and physical activity.Conclusions
Exclusive breastfeeding seems a natural way of slightly improving some physical fitness components (mainly lower-body muscle strength) and thus future health.93.
94.
95.
Joakim Ekberg Toomas Timpka Magnus B?ng Anders Fr?berg Karin Halje Henrik Eriksson 《BMC medical research methodology》2011,11(1):3
Background
Reviews of randomized controlled trials (RCTs) of cognitive behavioural therapy (CBT) for anxiety disorders have reported large pre- to post-treatment within-group effect sizes on measures of anxiety when supplied in therapist consultations and in technology-supported settings. However, the stringent experimental control of RCTs results in a lack of external validity, which limits the generalizability of findings to real-world frontline clinical practice. We set out to examine the specification of a protocol for study of the effectiveness of cell phone-supported CBT for in situ management of anxiety disorders. 相似文献96.
Marju Kase Ave Minajeva Kristi Niinepuu Sandra Kase Markus Vardja Toomas Asser Jana Jaal 《Radiology and oncology》2013,47(4):405-410
Background
The aim of the study was to assess the impact of CD133-positive (CD133+) cancer stem cell proportions on treatment results of glioblastoma multiforme (GBM) patients.Patients and methods
Patients with GBM (n = 42) received postoperative radiotherapy (± chemotherapy). Surgically excised GBM tissue sections were immunohistochemically examined for CD133 expression. The proportions of CD133+ GBM cells were determined (%). The proportion of CD133+ GBM stem cells was established by 2 independent researchers whose results were in good accordance (R = 0.8, p < 0.01). Additionally, CD133 expression levels were correlated with patients overall survival.Results
The proportion of CD133+ cells varied between patients, being from 0.5% to 82%. Mean and median proportions of CD133+ cells of the entire study group were 33% ± 24% (mean ± SD) and 28%, respectively. Clinical data do not support the association between higher proportion of stem cells and the aggressiveness of GBM. Median survival time of the study group was 10.0 months (95% CI 9.0–11.0). The survival time clearly depended on the proportion of CD133+ cells (log rank test, p = 0.02). Median survival times for patients with low (< median) and high (≥ median) proportion of CD133+ cells were 9.0 months (95% CI 7.6–10.5) and 12.0 months (95% CI 9.3–14.7), respectively. In multivariate analysis, the proportion of CD133+ cells emerged as a significant independent predictor for longer overall survival (HR 2.0, 95% CI 1.0–3.8, p = 0.04).Conclusions
In patients with higher stem cell proportion, significantly longer survival times after postoperative radiotherapy were achieved. Underlying reasons and possible higher sensitivity of GBM stem cells to fractionated radio-therapy should be clarified in further studies. 相似文献97.
98.
Idoia Labayen Jonatan R. Ruiz Francisco B. Ortega Helle-Mai Loit Jaanus Harro Toomas Veidebaum Michael Sj?str?m 《Diabetes care》2010,33(4):894-900
OBJECTIVE
To examine the association between parental BMI and offspring cardiovascular disease (CVD) risk factors.RESEARCH DESIGN AND METHODS
The study comprised 940 children (9.5 ± 0.4 years) and 873 adolescents (15.5 ± 0.5 years). Parental weight and height were reported by the mother and the father, and BMI was calculated. CVD risk factors included total (sum of five skinfolds) and central (waist circumference) body fat, blood pressure, cardiorespiratory fitness, insulin sensitivity, total cholesterol, HDL cholesterol, triglycerides, and fibrinogen.RESULTS
Maternal and paternal BMI were positively associated with total and central fatness in offspring (P < 0.001). BMIs of both parents were significantly related to fibrinogen levels (P < 0.02), but these associations disappeared when controlling for fatness. There was a positive relationship between maternal and paternal BMI and waist circumference in the offspring regardless of total adiposity and height (P < 0.001). Maternal BMI was negatively associated with offspring cardiorespiratory fitness independently of fatness (P < 0.02). These relationships persisted when overweight descendants were excluded from the analysis. There were no significant associations between parental BMI and the other CVD risk factors.CONCLUSIONS
Both maternal and paternal BMI increase CVD risk factors of their offspring, characterized by total and central body fat, and higher maternal BMI was associated with poorer cardiorespiratory fitness. Our findings give further support to the concept that adiposity in parents transmits susceptibility to CVD risk to descendants, which is detectable even in the absence of overweight in offspring.Parental obesity substantially increases the risk of obesity in offspring through genetic, biological, or environmental influences (1). The fetal overnutrition hypothesis suggests that maternal obesity and/or gestational diabetes may predispose offspring to increased adiposity in adulthood (2). Human studies showed a greater influence of maternal than paternal BMI on offspring adiposity (3,4). In contrast, others suggested that the contribution of the mother and the father on both prenatal and postnatal programming of intergenerational obesity may be similar according to the genomic imprinting (5).Most of the studies focused on the relationships of maternal and paternal BMI with their offspring BMI provided contradictory results (3,6,7), and only one study compared the association of maternal and paternal BMI with total body fat in the offspring (8). Whether the parental BMI-offspring body fat relationship applies to other established cardiovascular disease (CVD) risk factors remains to be elucidated.Excess adiposity leads to increased CVD risk factors and biological pathway alterations as insulin resistance, dyslipemia, hypertension, systemic inflammation, and low cardiorespiratory fitness (9). Therefore, the parental BMI-offspring CVD risk factor relationship may be influenced by the offspring body composition.The European Youth Heart Study (EYHS) provides an opportunity to better understand the parental-descendant aggregation of CVD factors by controlling for other potential confounding factors that could mediate in this relationship. Therefore, the aim of this study was to determine the association between both maternal and paternal BMI and the offspring CVD risk factors including total and central body fat, cardiorespiratory fitness, insulin sensitivity, blood pressure, blood lipids, and fibrinogen. We also examined the role of offspring adiposity in this relationship. 相似文献99.
Timing of solid food introduction and association with later childhood overweight and obesity: The IDEFICS study
下载免费PDF全文
![点击此处可从《Maternal & child nutrition》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Stalo Papoutsou Savvas C. Savva Monica Hunsberger Hannah Jilani Nathalie Michels Wolfgang Ahrens Michael Tornaritis Toomas Veidebaum Dénes Molnár Alfonso Siani Luis A. Moreno Charis Hadjigeorgiou 《Maternal & child nutrition》2018,14(1)
This study investigated associations between timing of solid food introduction and childhood obesity and explored maternal characteristics influencing early feeding practices. Cross‐sectional data from children 2–9 years (n = 10,808; 50.5% boys) residing in 8 European countries of the IDEFICS study (2007–2008) were included. Late solid food introduction (≥7 months of age) was associated with an increased prevalence of later childhood overweight/obesity among exclusively breastfed children (OR [odds ratio]: 1.38, 95% CI [confidence interval] [1.01, 1.88]). In contrast, early solid food introduction (<4 months of age) was associated with lower prevalence of overweight/obesity among children that ceased exclusive breastfeeding earlier than 4 months (OR: 0.63, 95% CI [0.47, 0.84]). Children that were introduced to solids right after 6 months exclusive breastfeeding and continued to receive breastmilk (≥12 months) were less likely to become overweight/obese (OR: 0.67, 95% CI [0.51, 0.88]) compared to children that discontinued to receive breastmilk. Analyses were adjusted for age, sex, country, birth weight, parental education level, parental body mass index, tobacco use in pregnancy, gestational weight gain, and gestational diabetes. Underweight mothers, overweight mothers, mothers who reported daily smoking during pregnancy, and low‐educated mothers were less likely to follow recommendations on breastfeeding and timely solids introduction. Future studies should examine whether guidelines for solid food introduction timing have to distinguish between exclusively breastfed, formula fed, and too early exclusive breastfeeding‐ceased infants. There is also need for more prospective studies; recall bias was an important current limitation. In conclusion, health professionals should emphasize benefits of breastfeeding and appropriate solid food introduction, especially to mothers that are less likely to follow recommendations. 相似文献
100.
Pascal Edouard Astrid Junge Marianna Kiss-Polauf Christophe Ramirez Monica Sousa Toomas Timpka Pedro Branco 《Journal of Science and Medicine in Sport》2018,21(9):894-898