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71.
MtDNA Profile of West Africa Guineans: Towards a Better Understanding of the Senegambia Region 总被引:1,自引:1,他引:1
Alexandra Rosa António Brehm Toomas Kivisild Ene Metspalu Richard Villems 《Annals of human genetics》2004,68(4):340-352
The matrilineal genetic composition of 372 samples from the Republic of Guiné‐Bissau (West African coast) was studied using RFLPs and partial sequencing of the mtDNA control and coding region. The majority of the mtDNA lineages of Guineans (94%) belong to West African specific sub‐clusters of L0‐L3 haplogroups. A new L3 sub‐cluster (L3h) that is found in both eastern and western Africa is present at moderately low frequencies in Guinean populations. A non‐random distribution of haplogroups U5 in the Fula group, the U6 among the “Brame” linguistic family and M1 in the Balanta‐Djola group, suggests a correlation between the genetic and linguistic affiliation of Guinean populations. The presence of M1 in Balanta populations supports the earlier suggestion of their Sudanese origin. Haplogroups U5 and U6, on the other hand, were found to be restricted to populations that are thought to represent the descendants of a southern expansion of Berbers. Particular haplotypes, found almost exclusively in East‐African populations, were found in some ethnic groups with an oral tradition claiming Sudanese origin. 相似文献
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73.
The acceptability of computerized assessment of alcohol habits was explored in 57 consecutive out-patients over a 6-month period. Altogether, 46 men and 11 women agreed to complete a paper and pencil questionnaire exploring their opinion about computerized assessment. The study focused on the patients' acceptance of computerized testing and also on whether some sub-groups had reservations. The participants indicated that they had no general anxiety towards computers and did not mind being assessed by their use. Nearly half of the men were not convinced of the usefulness of computers as a means of asking about alcohol habits. The same level of confidence was recorded with regard to whether doctors would make better assessments using computers. Around one-quarter of both men and women were worried that computers might cause doctors to spend less time with the patients and that staff might lose the personal contact with patients. Because of the small sample size, we conclude tentatively that a computerized lifestyle test appears to be an acceptable method both to men and women with different educational backgrounds. However, two important issues need to be further addressed, namely concerns about confidentiality and loss of personal contact. 相似文献
74.
The effect of cat odor exposure was studied on morphine-induced increase of exploratory behavior and on the expression of opioid genes in forebrain structures of male Wistar rats. Treatment with morphine (1 mg/kg) induced a significant increase in exploratory behavior in an unfamiliar environment in rats. Previous exposure of animals to cat odor completely abolished this stimulating action of mu-opioid receptor agonist on exploratory activity. Cat odor exposure induced a significant increase in the expression of pro-opio-melanocortin (POMC) and mu-opioid receptor (MOR) genes in the brain structures related to anxiety and motivation. This study clearly demonstrates that cat odor exposure increases the activity of opioid system in rat forebrain structures. 相似文献
75.
The use of interleukin 12-secreting neural stem cells for the treatment of intracranial glioma 总被引:33,自引:0,他引:33
Neural stem cells (NSCs) are capable of tracking migrating glioma cells. To exploit this tropism to generate an antitumor T-cell response, particularly against disseminating tumor pockets, we inoculated intracranial glioma-bearing mice with interleukin 12 (IL-12) producing NSCs. Intratumoral therapy with IL-12-secreting NSCs prolonged survival compared to treatment with nonsecretory NSCs or saline. NSCs demonstrated strong tropism for disseminating glioma, and IL-12-secreting NSC therapy was associated with enhanced T-cell infiltration in tumor microsatellites and long-term antitumor immunity. These results indicate that the use of tumor tracking NSCs represents a potent new therapeutic modality for glioma. 相似文献
76.
Proactive health computing 总被引:1,自引:0,他引:1
Timpka T 《Artificial intelligence in medicine》2001,23(1):13-24
In an analysis departing from the global health situation, the foundation for a change of paradigm in health informatics based on socially embedded information infrastructures and technologies is identified and discussed. It is shown how an increasing computing and data transmitting capacity can be employed for proactive health computing. As a foundation for ubiquitous health promotion and prevention of disease and injury, proactive health systems use data from multiple sources to supply individuals and communities evidence-based information on means to improve their state of health and avoid health risks. The systems are characterised by: (1) being profusely connected to the world around them, using perceptual interfaces, sensors and actuators; (2) responding to external stimuli at faster than human speeds; (3) networked feedback loops; and (4) humans remaining in control, while being left outside the primary computing loop. The extended scientific mission of this new partnership between computer science, electrical engineering and social medicine is suggested to be the investigation of how the dissemination of information and communication technology on democratic grounds can be made even more important for global health than sanitation and urban planning became a century ago. 相似文献
77.
Liis Sabre Tiina Rekand Toomas Asser Janika K?rv 《The journal of spinal cord medicine》2013,36(6):687-694
AbstractStudy designRetrospective population-based study with mortality follow-up.ObjectiveTo study mortality, causes and risk factors for death in Estonian patients with traumatic spinal cord injury (TSCI).SettingAll Estonian hospitals.MethodsMedical records of patients with TSCI from all regional, central, general, and rehabilitation hospitals in Estonia from 1997 to 2007, were retrospectively reviewed. Mortality status was ascertained as of 31 December 2011. Causes of death were collected from the Estonian Causes of Death Registry. Standardized mortality ratios (SMRs) were calculated for the entire sample and for causes of death. A Cox proportional hazards modeling was used to identify the risk indicators for death.ResultsDuring the observation period (1997–2011) 162 patients of 595 died. Nearly half of the patients (n = 76) died during the first year after TSCI. The main causes of death were external causes (30%), cardiovascular disease (29%). and suicide (8%). The overall SMR was 2.81 (95% confidence interval 2.40–3.28) and SMR was higher for women than for men (3.80 vs. 2.70). Cause-specific SMRs were markedly elevated for sepsis and suicide. Mortality was significantly affected by the age at the time of injury, neurological level, and extent of the injury as well as the year of TSCI and complications.ConclusionLife expectancy is significantly decreased in patients with TSCI in Estonia compared with the general population. Deaths during the first year after the injury have an important impact on statistics. Treatment of cardiovascular diseases, infections, and prevention of suicide are useful for reducing mortality in patients with TSCI. 相似文献
78.
Christine Delisle Nystr?m Elisabet Forsum Hanna Henriksson Ylva Trolle-Lagerros Christel Larsson Ralph Maddison Toomas Timpka Marie L?f 《Nutrients》2016,8(1)
Mobile phones are becoming important instruments for assessing diet and energy intake. We developed the Tool for Energy Balance in Children (TECH), which uses a mobile phone to assess energy and food intake in pre-school children. The aims of this study were: (a) to compare energy intake (EI) using TECH with total energy expenditure (TEE) measured via doubly labelled water (DLW); and (b) to compare intakes of fruits, vegetables, fruit juice, sweetened beverages, candy, ice cream, and bakery products using TECH with intakes acquired by 24 h dietary recalls. Participants were 39 healthy, Swedish children (5.5 ± 0.5 years) within the ongoing Mobile-based Intervention Intended to Stop Obesity in Preschoolers (MINISTOP) obesity prevention trial. Energy and food intakes were assessed during four days using TECH and 24 h telephone dietary recalls. Mean EI (TECH) was not statistically different from TEE (DLW) (5820 ± 820 kJ/24 h and 6040 ± 680kJ/24 h, respectively). No significant differences in the average food intakes using TECH and 24 h dietary recalls were found. All food intakes were correlated between TECH and the 24 h dietary recalls (ρ = 0.665–0.896, p < 0.001). In conclusion, TECH accurately estimated the average intakes of energy and selected foods and thus has the potential to be a useful tool for dietary studies in pre-school children, for example obesity prevention trials. 相似文献
79.
Jenny Jacobsson Armin Spreco Jan Kowalski Toomas Timpka Örjan Dahlström 《Journal of Science and Medicine in Sport》2021,24(7):627-634
ObjectivesThe aim was to describe levels of subjective Health Literacy (HL), and to examine possible differences in prevalence proportions between sexes, age groups and level of educations among youth athletes and their mentors (coaches, parents/caregivers) in Swedish Athletics.DesignCross-sectional.MethodsData on subjective HL were collected using the Swedish Communicative and Critical Health Literacy (S-CCHL) instrument for mentors and for youth the School-Aged Children (HLSAC) instrument. Questions assessing mentors’ literacy on sports injury and return to play were also included.ResultsThe surveys were completed by 159 (91%) mentors and 143 youth athletes (87%). The level of S-CCHL was sufficient in 53% of the mentors. Of youth athletes, 28% reported a high level of HL and the item with least perceived high HL (21%) was critical thinking. Ninety-four percent of the mentors believed that it is quite possible to prevent injuries in athletics and 53% perceived having a very good knowledge about how to prevent injuries. Forty-six percent of the mentors perceived having a very good knowledge of return to sport criteria.ConclusionsThe level of health literacy was low with about half of the mentors and one out of three youth athletes having adequate HL levels. Only half of the mentors stated having a good knowledge of various injury prevention strategies. To reduce health consequences in youth sport and enable talent development more work is needed to understand the facilitators and barriers for the uptake of various health promotion and injury prevention strategies. 相似文献
80.
Toomas Timpka Armin Spreco ?rjan Dahlstr?m Olle Eriksson Elin Gursky Joakim Ekberg Eva Blomqvist Magnus Str?mgren David Karlsson Henrik Eriksson James Nyce Jorma Hinkula Einar Holm 《Journal of medical Internet research》2014,16(4)