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Several latentiated derivatives of 3-methyleneoxindole were synthesized and examined for cytotoxic activity. The latentiated forms are represented by three general types which differ in leaving and cleaved groups. All are expected to be converted into 3-methyleneoxindole by bioactivation processes normally occurring in the cell. Two compounds were tested against L-1210 lymphoid leukemia, and six were tested against P-388 lymphocytic leukemia; all were inactive. 相似文献
453.
Gatenby RA; Hartz WH; Engstrom PF; Rosenblum JS; Hammond ND; Kessler HB; Moldofsky PJ; Clair MR; Unger E; Broder GJ 《Radiology》1987,163(1):172-175
Photodynamic therapy was performed on ten tumors in patients who did not respond to initial therapy and for whom no additional conventional therapy was available. A sensitizing agent (hematoporphyrin derivative [HpD]) was injected directly into each tumor under computed tomographic (CT) guidance to deliver high concentrations to the tumor and to minimize systemic toxicity. Three to 6 days after the injection, a clear Teflon sheath catheter was placed into the tumor under CT guidance. The tumor was exposed to red light (630-nm wavelength) through laser fiberoptics inserted in the sheath. The initial investigation confirmed the technical feasibility of CT-guided photodynamic therapy by means of intratumoral HpD injections and laser exposure through fiberoptics inserted in sheath catheters. The toxicity from a single treatment was minor, and the tumor response was encouraging. 相似文献
454.
背景:HBV感染患者的阿德福韦耐药性发生率和危险因素尚未明确。目的:探讨阿德福韦病毒学应答的特征、明确阿德福韦耐药的发生率并研究起始病毒学应答(Initial Virologic Response,IVR) 和阿德福韦耐药的相关因素。 相似文献
455.
Daniel Thio Phillip Reece Rory Herdman 《European archives of oto-rhino-laryngology》2008,265(8):907-910
Necrotizing otitis externa is a necrotizing osteomyelitis of the skull base that predominantly affects diabetic and immunocompromised patients. Pseudomonas aeruginosa is the most frequently implicated organism. Patients present with severe otalgia, otorrhoea with or without facial palsy, or rarely, facial pain as a symptomatic feature. We report a case of necrotizing otitis externa presenting with totally painless otorrhoea and highlight the need for a high index of suspicion when treating patients with otitis externa. 相似文献
456.
Liu Lin Thio Nicholas Rensing Susan Maloney David F. Wozniak Chengjie Xiong Kelvin A. Yamada 《Epilepsia》2010,51(8):1619-1623
The effect of the ketogenic diet on behavior and cognition is unclear. We addressed this issue in rats behaviorally and electrophysiologically. We fed postnatal day 21 rats a standard diet (SD), ketogenic diet (KD), or calorie‐restricted diet (CR) for 2–3 weeks. CR controlled for the slower weight gain experienced by KD‐fed rats. We assessed behavioral performance with a locomotor activity and a conditioned fear test. To evaluate possible parallel effects of diet on synaptic function, we examined paired‐pulse modulation (PPM) and long‐term potentiation (LTP) in the medial perforant path in vivo. KD‐fed rats performed similarly to SD‐fed rats on the behavioral tests and electrophysiologic assays. These data suggest that the KD does not alter behavioral performance or synaptic plasticity. 相似文献
457.
Free immunoglobulin light chains: a novel target in the therapy of inflammatory diseases 总被引:1,自引:0,他引:1
In recent years, novel therapeutic strategies have become available for the treatment of chronic inflammatory disease. Neutralizing proinflammatory mediators such as leukotrienes and TNF-alpha, in addition to anti-IgE therapies (Omaluzimab) that target higher in the inflammatory cascade, have shown success in the treatment of allergic or autoimmune disorders. Free immunoglobulin light chains, which are produced by B lymphocytes and secreted into serum, might play a crucial role in the pathogenesis of inflammatory disease. Concentrations of free light chains are significantly increased under diverse pathological conditions in humans, and have been linked to the progression and severity of immune diseases. Here we discuss the importance of free immunoglobulin light chains as a potential therapeutic target in the treatment of chronic inflammatory disease. 相似文献
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