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排序方式: 共有1364条查询结果,搜索用时 199 毫秒
61.
Hideki Nagashima Yasuo Morio Shunsuke Meshitsuka Koji Yamane Yoshiro Nanjo Ryota Teshima 《European spine journal》2010,19(8):1363-1368
There have been few reports describing substances related to oxidative and intermediary metabolism in the cerebrospinal fluid
(CSF) in patients with spinal degenerative disorders. This study investigated whether the concentrations of metabolites in
the CSF differed between patients with spinal degenerative disorders and controls, and whether the concentrations of these
metabolites correlated with the severity of symptoms. CSF samples were obtained from 30 patients with cervical myelopathy
(Group M), 30 patients with lumbar radiculopathy (Group R), and 10 volunteers (control). Metabolites in these CSF samples
were measured by nuclear magnetic resonance spectroscopy. There were no differences in the concentrations of lactate, alanine,
acetate, glutamate, pyruvate, or citrate between Groups M and R, between Group M and the control, or between Group R and the
control. In Group M, neither symptom duration nor the Japanese Orthopaedic Association score correlated with the concentration
of any metabolite. In Group R, the symptom duration positively correlated with the concentration of lactate, glutamate, and
citrate in CSF. The duration of nerve root block showed a negative correlation with the concentrations of acetate in CSF of
the patients in Group R. In patients with lumbar radiculopathy, there is a possibility of increased aerobic metabolic activity
or decreased gluconeogenic activity in patients with shorter symptom duration, and increased aerobic metabolic activity in
patients with severe inflammation around a nerve root. 相似文献
62.
K Noda K Teshima K Tekeuti K Hasegawa K Inoue K Yamashita I Sawaragi T Nakajima E Takashima M Ikeuchi 《Gynecologic oncology》1989,35(3):367-372
The efficacy of immunotherapy using a streptococcal preparation, OK-432, was evaluated in each clinical stage of uterine cervical cancer. The 382 eligible patients were stratified by clinical stage and presence/absence of surgery. Within each stratum, patient's were randomly allocated to OK-432 treatment or to control treatment. OK-432 significantly inhibited recurrence in patients with stage II cervical cancer; the recurrence-free interval and survival time were remarkably prolonged in patients with stage II disease who underwent surgery. However, OK-432 did not significantly prolong these parameters in patients with stage III disease. Retrospective analyses revealed that in patients with or without lymph node metastases who underwent surgery, the recurrence-free interval and survival time were significantly prolonged by OK-432 treatment. These results indicate that OK-432 is an effective and useful postoperative immunotherapeutic agent for uterine cervical cancer. 相似文献
63.
In this paper, the assessment of radiographic vertebral fracture (prevalent fracture and incident fracture) in the diagnosis of osteoporosis and the therapeutical assessment by bone mineral density measurements are reviewed. 相似文献
64.
Teshima H Hayashida N Nishimi M Tayama E Fukunaga S Tomoeda H Chihara S Enomoto N Kawara T Aoyagi S 《Artificial organs》2002,26(5):460-466
This study was conducted to determine the effect of thrombolytic therapy with tissue plasminogen activator (t-PA) for nonstructural malfunction of bileaflet cardiac valve prostheses. Twenty-seven patients with bileaflet prosthetic valve malfunction diagnosed by a combination of cineradiography and transthoracic echocardiography were treated with the administration of intravenous t-PA. The treatment resulted in complete success in 55.6% (15 of 27), partial success in 22.2% (6 of 27), and no change in 22.2% (6 of 27). In the complete success and partial success groups, the condition of the patients in 85.7% (18 of 21) of the cases improved within 24 h after the administration of t-PA. Six cases in whom thrombolytic therapy was instituted more than 1 month (ranged from 1 to 38 months, mean 14.7 months) after the diagnosis of prosthetic valve malfunction showed significantly less effectiveness of thrombolytic therapy with t-PA. Only one patient (3.7%) had a major complication (thromboembolism) after t-PA treatment. The results suggest that thrombolytic therapy with t-PA in patients with nonstructural malfunction of bileaflet cardiac valve prostheses is effective with low incidence of complication when the treatment is instituted early after the diagnosis. 相似文献
65.
66.
Over-expression of the dominant-negative isoform of Ikaros confers resistance to dexamethasone-induced and anti-IgM-induced apoptosis 总被引:2,自引:0,他引:2
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69.
Nagashima H Morio Y Nishi T Hagino H Teshima R 《Clinical orthopaedics and related research》2002,(403):104-107
This is the first case report of a child with isthmic spondylolisthesis and discitis who had spontaneous fusion develop at an unstable level with relief of symptoms after nonoperative treatment. Although the blood culture was negative, the 14-year-old boy with Grade III isthmic spondylolisthesis of L5 was diagnosed with discitis at the L5-S1 level, based on clinical findings, elevated C-reactive protein, plain radiographs, and magnetic resonance imaging scans. The patient was treated with antibiotics for 19 weeks and bed rest for 4 weeks followed by immobilization in a hip spica cast for 8 weeks and a thoracolumbosacral orthosis for an additional 12 weeks. The lumbar back pain improved and there was a decrease in C-reactive protein to the normal range 3 weeks after onset. Forty months from onset, the patient was free from lumbar back or leg pain and his clinical neurologic examination was normal. Plain radiographs showed spontaneous fusion between L5 and the sacrum. This suggests that nonoperative treatment is acceptable even if discitis occurs at an unstable level. 相似文献
70.
Uno T Sumi M Ikeda H Teshima T Yamashita M Inoue T;Japanese PCS Working Subgroup of Lung Cancer 《Lung cancer (Amsterdam, Netherlands)》2002,35(3):279-285
The Patterns of Care Study (PCS) conducted a nationwide audit survey in order to establish the national practice process of radiation therapy for small-cell lung cancer (SCLC) and examined the influence of institutional stratification on the process of care in Japan. The PCS randomly sampled institutions and patients using a two-stage cluster method and surveyed the process of radiation therapy for 174 stage I-III SCLC patients according to the category of institution, stratified as follows: A1, academic institutions treating > or = 300 patients a year; A2, <300 patients; B1, non-academic institutions treating > or = 120 patients a year; and B2, <120 patients. Karnofsky performance status distributions showed significant variance by stratification of institutions (P=0.013). Patients treated on an outpatient basis accounted for 32% in A1, 23% in A2, 8% in B1, but only 5% in B2 (P=0.007). A photon energy > or = 10 MV was used for 87% of patients in A1, 69% in A2, 54% in B1 and 23% in B2 (P=0.001). Contralateral hilus was irradiated for 11% of patients in A1, 17% in A2, 29% in B1 and 3% in B2 (P=0.001). Field size reduction during the treatment course was done for 77% of patients in A1, 54% in A2, 60% in B1 and 42% in B2 (P=0.007). Ninety-two percent of patients received combined chemotherapy and radiation therapy, and the most frequently used drugs were etoposide (91%) and cisplatin (69%). The results of clinical studies on SCLC had favorably penetrated into the clinical practice. However, the stratification of institutions significantly affected the process of radiation therapy in Japan. 相似文献