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951.
952.
Marjo Okkonen Aki S. Havulinna Olavi Ukkola Heikki Huikuri Arto Pietil Heli Koukkunen Seppo Lehto Juha Mustonen Matti Ketonen Juhani Airaksinen Y. Antero Kesniemi Veikko Salomaa 《Annals of medicine》2021,53(1):817
AimsTo evaluate risk factors for major adverse cardiac event (MACE) after the first acute coronary syndrome (ACS) and to examine the prevalence of risk factors in post-ACS patients.MethodsWe used Finnish population-based myocardial infarction register, FINAMI, data from years 1993–2011 to identify survivors of first ACS (n = 12686), who were then followed up for recurrent events and all-cause mortality for three years. Finnish FINRISK risk factor surveys were used to determine the prevalence of risk factors (smoking, hyperlipidaemia, diabetes and blood pressure) in post-ACS patients (n = 199).ResultsOf the first ACS survivors, 48.4% had MACE within three years of their primary event, 17.0% were fatal. Diabetes (p = 4.4 × 10−7), heart failure (HF) during the first ACS attack hospitalization (p = 6.8 × 10−15), higher Charlson index (p = 1.56 × 10−19) and older age (p = .026) were associated with elevated risk for MACE in the three-year follow-up, and revascularization (p = .0036) was associated with reduced risk. Risk factor analyses showed that 23% of ACS survivors continued smoking and cholesterol levels were still high (>5mmol/l) in 24% although 86% of the patients were taking lipid lowering medication.ConclusionDiabetes, higher Charlson index and HF are the most important risk factors of MACE after the first ACS. Cardiovascular risk factor levels were still high among survivors of first ACS. 相似文献
953.
Higher circulating EGF levels associate with a decreased risk of IgE sensitization in young children
954.
955.
Heidi Hongisto Jennifer M Dewing David RG Christensen Jennifer Scott Angela J Cree Janika Nättinen Juha Määttä Antti Jylhä Ulla Aapola Hannu Uusitalo Kai Kaarniranta J Arjuna Ratnayaka Heli Skottman Andrew J Lotery 《The Journal of pathology》2020,252(2):138-150
Sorsby fundus dystrophy (SFD) is a rare autosomal dominant disease of the macula that leads to bilateral loss of central vision and is caused by mutations in the TIMP3 gene. However, the mechanisms by which TIMP3 mutations cause SFD are poorly understood. Here, we generated human induced pluripotent stem cell-derived retinal pigmented epithelial (hiPSC-RPE) cells from three SFD patients carrying TIMP3 p.(Ser204Cys) and three non-affected controls to study disease-related structural and functional differences in the RPE. SFD-hiPSC-RPE exhibited characteristic RPE structure and physiology but showed significantly reduced transepithelial electrical resistance associated with enriched expression of cytoskeletal remodelling proteins. SFD-hiPSC-RPE exhibited basolateral accumulation of TIMP3 monomers, despite no change in TIMP3 gene expression. TIMP3 dimers were observed in both SFD and control hiPSC-RPE, suggesting that mutant TIMP3 dimerisation does not drive SFD pathology. Furthermore, mutant TIMP3 retained matrix metalloproteinase activity. Proteomic profiling showed increased expression of ECM proteins, endothelial cell interactions and angiogenesis-related pathways in SFD-hiPSC-RPE. By contrast, there were no changes in VEGF secretion. However, SFD-hiPSC-RPE secreted higher levels of monocyte chemoattractant protein 1, PDGF and angiogenin. Our findings provide a proof-of-concept that SFD patient-derived hiPSC-RPE mimic mature RPE cells and support the hypothesis that excess accumulation of mutant TIMP3, rather than an absence or deficiency of functional TIMP3, drives ECM and angiogenesis-related changes in SFD. © 2020 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd. 相似文献
956.
957.
Flaubert Sena de Medeiros Epifanio Silvino do Monte Junior Romero de Lima Fran a Heli Cl vis de Medeiros Neto Juliany Medeiros Santos Eligio Alves Almeida J nior Samuel Oliveira da Silva J nior Mario Herman Santos Moura Pedreira Tavares Eduardo Guimar es Hourneaux de Moura 《World journal of gastrointestinal endoscopy》2020,12(11):493-499
958.
959.
Ilpo Huhtaniemi Outi Hovatta Antonio La Marca Gabriel Livera Danielle Monniaux Luca Persani Abdelkader Heddar Katarzyna Jarzabek Triin Laisk-Podar Andres Salumets Juha S. Tapanainen Reiner A. Veitia Jenny A. Visser Peter Wieacker Slawomir Wolczynski Micheline Misrahi 《Trends in Endocrinology and Metabolism》2018,29(6):400-419
960.
Sanna Sinikallio Timo Aalto Heli Koivumaa-Honkanen Olavi Airaksinen Arto Herno Heikki Kröger Heimo Viinamäki 《European spine journal》2009,18(8):1187-1193
The aim of this study was to examine the life satisfaction of lumbar spinal stenosis (LSS) patients up to the 2-year postoperative
phase. Patients (N = 102, mean age, 62 years) with symptomatic LSS underwent decompressive surgery. Data collection took place with the same
set of questionnaires before surgery and 3 months, 6 months, 1 year and 2 years postoperatively. Life satisfaction was assessed
with the four-item Life Satisfaction scale and depression symptoms with the 21-item Beck Depression Inventory (BDI). In addition,
a depression burden variable was included, comprising the sum of preoperative, 3- and 6-month BDI scores. Physical functioning
and pain were assessed with the Oswestry disability index, Stucki questionnaire, self-reported walking ability, visual analogy
scale and pain drawing. Two years postoperatively, 18% of the LSS patients was dissatisfied with their lives. As a whole,
the life satisfaction of the LSS patients improved during the postoperative follow-up, reaching the level of the healthy adult
Finnish population. However, 2 years postoperatively, dissatisfied patients reported significantly more pain, a poorer functional
ability and more depressive symptoms and depression than the patients who were satisfied with life. This difference was seen
throughout the postoperative follow up. In regression analyses, the only significant associations were between the depression
burden and postoperative life dissatisfaction. Thus, subjective well-being as well as depression among LSS patients should
be assessed pre- and postoperatively in order to enable early intervention for those at risk of poorer life satisfaction. 相似文献