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91.
Number and function of circulating human antigen presenting cells regulated by sleep 总被引:5,自引:0,他引:5
STUDY OBJECTIVES: There is evidence that sleep facilitates the adaptive immune response to infectious agents and, thereby, supports immunologic memory. The effect might be attained by sleep-induced changes in the number and function of dendritic cells (DCs), which play a key role in the initiation of the immune response. This study aimed to dissociate effects of sleep and circadian rhythm on circulating numbers of DC precursors, ie, CD14+CD16- and CD14(dim)CD16+ monocytes, myeloid dendritic cell precursors (pre-mDC), and plasmacytoid dendritic cells (PDC) and on 2 key cytokines produced by these cells, ie, interleukin (IL)-12 and interferon (IFN)-alpha. DESIGN: In a within-subject cross-over design, human subjects were examined on 2 occasions, ie, during a normal sleep-wake cycle and during 24 hours of wakefulness. Blood was sampled every 1.5 hours during nighttime and every 3 hours during daytime. SETTING: Experiments took place under controlled laboratory conditions. PARTICIPANTS: Twenty-seven healthy men aged between 18 and 30 years. MEASUREMENTS AND RESULTS: Compared with wakefulness, sleep was associated with a striking increase in the number of pre-mDC producing IL-12, which is a main inducer of Th1 responses. In addition, sleep slightly decreased PDC and also T cell counts but did not affect IFN-alpha production by PDC. Sleep, however, substantially decreased numbers of CD14(dim)CD16+ monocytes, probably reflecting increased margination of the cells upon a sleep-related drop in catecholamine release. CONCLUSIONS: Our data identify pre-mDC producing IL-12 as a basic target of sleep that is most closely related to mature APC function and whereby sleep can effectively enhance adaptive immune responses. 相似文献
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Zhenzhen Jia Joni Zhang Dulce Trindade Tanja Sobko 《Maternal and child health journal》2018,22(10):1526-1533
Objectives Many obesity-related chronic diseases originate from unhealthy childhood habits. The aim of this study was to describe 9-month-old infants’ physical activity levels and patterns and to examine the correlates. Understanding these factors is necessary for improving the effectiveness of physical activity intervention programs for infants. Methods In total, 143 infant–mother dyads from Macau, SAR China, participated in this study. Physical activity (PA) was assessed by using the Actigraph GT3X+ accelerometer and the demographic variables were collected by questionnaires. Results The most important findings were that: (1) infants had more screen time during weekdays (p?=?.044); (2) infants and mothers were least active at 8 a.m. (both weekdays and weekends) in the morning and most active at 7 p.m. (weekdays) and 8 p.m. (weekends) in the evening; (3) infants’ PA levels significantly correlated with their mothers’ PA intensities during the weekends (r?=?.192, p?=?.036), especially the mothers’ lower intensities in the mornings and evenings; (4) maternal BMI predicted the PA levels of the 9-month-old infants’ (R2?=?.06, β?=?29.188, p?=?.009). Conclusions for Practice Physical activity promotion programs for infants should be time-specific starting from early infancy. This study was one of the first to examine 9-month-old infants’ PA levels, patterns and correlates. The results may be helpful in improving the effectiveness of future healthy lifestyle intervention programs for infants in Macau and in the region in general. 相似文献
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Fabian Queissert Tanja Hüsch Alexander Kretschmer Ralf Anding Ruth Kirschner-Hermanns Tobias Pottek Roberto Olianas Alexander Friedl Roland Homberg Jesco Pfitzenmaier Carsten M. Naumann Joanne Nyarangi-Dix Torben Hofmann Achim Rose Josef Schweiger Wilhelm Hübner Hagen Loertzer Ricarda M. Bauer Axel Haferkamp Andres J. Schrader Debates On Male Incontinence -Project 《Neurourology and urodynamics》2020,39(6):1856-1861
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Hagen Loertzer Tanja Huesch Ruth Kirschner-Hermanns Ralf Anding Armin Rose Bernhard Brehmer Carsten Maik Naumann Fabian Queissert Joanne Nyarangi-Dix Roland Homberg Markus Grabbert Torben Hofmann Tobias Pottek Wilhelm Hübner Axel Haferkamp Ricarda Michaela Bauer Alexander Kretschmer 《Neurourology and urodynamics》2020,39(3):987-993
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Christian Bahrs Stojicevic Tanja Blumenstock Gunnar Brorson Stig Andreas Badke Stöckle Ulrich Rolauffs Bernd Freude Thomas 《International orthopaedics》2014,38(8):1697-1704