全文获取类型
| 收费全文 | 2033277篇 |
| 免费 | 143411篇 |
| 国内免费 | 3935篇 |
专业分类
| 耳鼻咽喉 | 30080篇 |
| 儿科学 | 59509篇 |
| 妇产科学 | 56325篇 |
| 基础医学 | 287965篇 |
| 口腔科学 | 61979篇 |
| 临床医学 | 176095篇 |
| 内科学 | 393491篇 |
| 皮肤病学 | 44891篇 |
| 神经病学 | 160682篇 |
| 特种医学 | 80355篇 |
| 外国民族医学 | 501篇 |
| 外科学 | 318519篇 |
| 综合类 | 45159篇 |
| 现状与发展 | 7篇 |
| 一般理论 | 641篇 |
| 预防医学 | 142078篇 |
| 眼科学 | 48593篇 |
| 药学 | 154877篇 |
| 7篇 | |
| 中国医学 | 4517篇 |
| 肿瘤学 | 114352篇 |
出版年
| 2018年 | 18725篇 |
| 2016年 | 16622篇 |
| 2015年 | 18715篇 |
| 2014年 | 25893篇 |
| 2013年 | 39020篇 |
| 2012年 | 51946篇 |
| 2011年 | 54809篇 |
| 2010年 | 32515篇 |
| 2009年 | 31403篇 |
| 2008年 | 52892篇 |
| 2007年 | 56679篇 |
| 2006年 | 57640篇 |
| 2005年 | 55744篇 |
| 2004年 | 54185篇 |
| 2003年 | 52222篇 |
| 2002年 | 51427篇 |
| 2001年 | 100650篇 |
| 2000年 | 103625篇 |
| 1999年 | 87417篇 |
| 1998年 | 22647篇 |
| 1997年 | 20455篇 |
| 1996年 | 19995篇 |
| 1995年 | 18875篇 |
| 1994年 | 17561篇 |
| 1993年 | 16297篇 |
| 1992年 | 67627篇 |
| 1991年 | 65408篇 |
| 1990年 | 64052篇 |
| 1989年 | 62323篇 |
| 1988年 | 57750篇 |
| 1987年 | 56642篇 |
| 1986年 | 53722篇 |
| 1985年 | 51398篇 |
| 1984年 | 37904篇 |
| 1983年 | 32386篇 |
| 1982年 | 18578篇 |
| 1981年 | 16809篇 |
| 1979年 | 35941篇 |
| 1978年 | 25294篇 |
| 1977年 | 21991篇 |
| 1976年 | 19669篇 |
| 1975年 | 22161篇 |
| 1974年 | 26436篇 |
| 1973年 | 25542篇 |
| 1972年 | 24290篇 |
| 1971年 | 22772篇 |
| 1970年 | 21678篇 |
| 1969年 | 20632篇 |
| 1968年 | 19226篇 |
| 1967年 | 17279篇 |
排序方式： 共有10000条查询结果，搜索用时 15 毫秒
101.
Oliver Sartor MD Daniel Heinrich MD Neil Mariados MD Maria José Méndez Vidal MD Daniel Keizman MD Camilla Thellenberg Karlsson MD Avivit Peer MD Giuseppe Procopio MD Stephen J. Frank MD Kalevi Pulkkanen MD Eli Rosenbaum MD Stefano Severi MD José Trigo MD Lucia Trandafir MD Volker Wagner MD Rui Li MS Luke T. Nordquist MD 《The Prostate》2019,79(14):1683-1691
102.
103.
104.
A.B. Sanchez-Spitman J.J. Swen V.O. Dezentje D.J.A.R. Moes H. Gelderblom 《Expert review of clinical pharmacology》2019,12(6):523-536
Introduction: Tamoxifen dominates the anti-estrogenic therapy in the early and metastatic breast cancer setting. Tamoxifen has a complex metabolism, being mainly metabolized by CYP2D6 into its 30–100 times more potent metabolite, endoxifen. Recently, a phase I study in which endoxifen as an orally z-endoxifen hydrochloride has been successfully evaluated.
Areas covered: the principal pharmacogenetic and non-genetic differences in the pharmacology of tamoxifen and endoxifen are evaluated. To this end, references from PubMed, Embase or Web of Science, among others, were reviewed As non-genetic factors, important differences and similarities such age, or adherence to tamoxifen therapy are comprehensively illustrated. Additionally, since CYP2D6 genotypes are considered the main limitation of tamoxifen, many studies have investigated the association between the worsened clinical outcomes in patients with non-functional CYP2D6 genotypes. In this review, an overview of the research on this field is presented. Also, a summary describing the literature about individualizing tamoxifen therapy with endoxifen concentrations and its limitations is listed.
Expert opinion: z-endoxifen hydrochloride is only investigated in the metastatic setting, still more research is required before its place in therapeutics is known. Similarly, monitoring tamoxifen efficacy based on endoxifen concentrations might not be overall recommended due to the limited evidence available. 相似文献
105.
Saisanjana Kalagara Adam E.M. Eltorai J. Mason DePasse Alan H. Daniels 《The spine journal》2019,19(1):182-185
BACKGROUND
Online physician rating websites are increasingly used by patients to evaluate their doctors. The purpose of this investigation was to evaluate factors associated with better spine surgeon ratings.METHODS
Orthopedic spine surgeons were randomly selected from the North American Spine Society directory utilizing a random number generator. Surgeon profiles on three physician rating websites, namely, www.HealthGrades.com, www.Vitals.com, and www.RateMDs.com, were analyzed to gather qualitative and quantitative data on patients’ perceptions of the surgeons. Independent variables from the websites were analyzed in relation to overall physician or patient satisfaction rating. Comments were coded by subject into following three categories: professional competence, bedside manner, and practice characteristics.RESULTS
A total of 250 surgeons were evaluated, and 92% (n=230) of these doctors had at least one rating among the three websites. The surgeons with a higher average rating had significantly better trust (p<.01), scheduling (p<.01), staff (p<.01), helpfulness (p<.01), and punctuality (p<.01) scores but significantly less experience (p<.05). A linear regression model for the average rating of each surgeon (R2 value=0.754) yielded only following three significant variables: trustworthiness (p<.01), experience match (p<.05), and the average number of negative comments on surgeon's professional competence (p<.05). Trustworthiness (β=0.749) was the strongest predictor variable of physician rating, followed by the number of negative professional competence comments (β=?0.132) and experience match (β=?0.112).CONCLUSIONS
This investigation assessed spine surgeon online patient ratings and categorized factors that patients associate with quality care. Trustworthiness was the most significant predictor of positive ratings, whereas ease of scheduling, quality of staff, helpfulness, and punctuality were also associated with higher patient ratings. Understanding what patients value may help optimize care of spine surgery patients. 相似文献106.
107.
108.
109.
Hanna Lee Mary K. Tan Andrew T. Yan Paul Angaran Paul Dorian Claudia Bucci Jean C. Gregoire Alan D. Bell Martin S. Green Peter L. Gross Allan Skanes Charles R. Kerr L. Brent Mitchell Jafna L. Cox Vidal Essebag Brett Heilbron Krishnan Ramanathan Carl Fournier Shaun G. Goodman 《The Canadian journal of cardiology》2019,35(2):160-168
Background
Physicians treating nonvalvular atrial fibrillation (AF) assess stroke and bleeding risks when deciding on anticoagulation. The agreement between empirical and physician-estimated risks is unclear. Furthermore, the association between patient and physician sex and anticoagulation decision-making is uncertain.Methods
We pooled data from 2 national primary care physician chart audit databases of patients with AF (Facilitating Review and Education to Optimize Stroke Prevention in Atrial Fibrillation and Coordinated National Network to Engage Physicians in the Care and Treatment of Patients with Atrial Fibrillation Chart Audit) with a combined 1035 physicians (133 female, 902 male) and 10,927 patients (4567 female and 6360 male).Results
Male physicians underestimated stroke risk in female patients and overestimated risk in male patients. Female physicians estimated stroke risk well in female patients but underestimated the risk in male patients. Risk of bleeding was underestimated in all. Despite differences in risk assessment by physician and patient sex, > 90% of patients received anticoagulation across all subgroups. There was modest agreement between physician estimated and calculated (ie, CHADS2 score) stroke risk: Kappa scores were 0.41 (0.35-0.47) for female physicians and 0.34 (0.32-0.36) for male physicians.Conclusions
Our study is the first to examine the association between patient and physician sex influences and stroke and bleeding risk estimation in AF. Although there were differences in agreement between physician estimated stroke risk and calculated CHADS2 scores, these differences were small and unlikely to affect clinical practice; further, despite any perceived differences in the accuracy of risk assessment by sex, most patients received anticoagulation. 相似文献110.
C. Jacquet F. Goehringer E. Baux J.A. Conrad M.O. Ganne Devonec J.L. Schmutz G. Mathey H. Tronel T. Moulinet I. Chary-Valckenaere T. May C. Rabaud 《Médecine et maladies infectieuses》2019,49(2):112-120