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991.
To evaluate the effects of distal design of a proximally coated femoral component on periprosthetic bone remodeling, we prospectively performed 21 one-stage bilateral total hip arthroplasties using a distally tapered and a distally cylindrical stem with the same proximal design, randomized to side. All hips showed good outcomes clinically and radiographically at the final follow-up, average of 7 years postoperatively. Cancellous condensation was always found in Gruen's zones 2 and 6 around the cylindrical stem and in regions between zones 2 and 3 and between zones 6 and 5 around the tapered stem. Bone mineral density of Gruen's zones 2 and 6 was significantly lower around the tapered stem. These results suggested more distal loading in hips with the tapered stem than in those with the cylindrical stem. 相似文献
992.
Hiroshi Takahashi Masashi Yamazaki Akihiko Okawa Tsuyoshi Sakuma Kei Kato Mitsuhiro Hashimoto Koichi Hayashi Takeo Furuya Takayuki Fujiyoshi Junko Kawabe Tomonori Yamauchi Chikato Mannoji Tomohiro Miyashita Ryo Kadota Masayuki Hashimoto Yasuo Ito Kazuhisa Takahashi Masao Koda 《European spine journal》2012,21(12):2580-2587
Objective
Granulocyte colony-stimulating factor (G-CSF) is a cytokine that is clinically used to treat neutropenia. G-CSF also has non-hematopoietic functions and could potentially be used to treat neuronal injury. To confirm the safety and feasibility of G-CSF administration for acute spinal cord injury (SCI), we have initiated a phase I/IIa clinical trial of neuroprotective therapy using G-CSF.Methods
The trial included a total of 16 SCI patients within 48 h of onset. In the first step, G-CSF (5 μg/kg/day) was intravenously administered for 5 consecutive days to 5 patients. In the second step, G-CSF (10 μg/kg/day) was similarly administered to 11 patients. We evaluated motor and sensory functions of patients using the American Spinal Cord Injury Association (ASIA) score and ASIA impairment scale (AIS) grade.Results
In all 16 patients, neurological improvement was obtained after G-CSF administration. AIS grade increased by one step in 9 of 16 patients. A significant increase in ASIA motor scores was detected 1 day after injection (P < 0.01), and both light touch and pin prick scores improved 2 days after injection (P < 0.05) in the 10 μg group. No severe adverse effects were observed after G-CSF injection.Conclusion
These results indicate that intravenous administration of G-CSF (10 μg/kg/day) for 5 days is essentially safe, and suggest that some neurological recovery may occur in most patients. We suggest that G-CSF administration could be therapeutic for patients with acute SCI. 相似文献993.
994.
Masateru Ono Kousuke Akiyama Makiko Kishida Masafumi Okawa Junei Kinjo Hitoshi Yoshimitsu Kazumoto Miyahara 《Journal of natural medicines》2013,67(4):822-826
Two new glycosidic acids, multifidinic acids F and G, were isolated from the glycosidic acid fraction afforded by alkaline hydrolysis of the ether-insoluble resin glycoside (convolvulin) fraction from the seeds of Quamoclit × multifida (syn. Q. sloteri House, Convolvulaceae), a hybrid between Q. pennata and Q. coccinea. The two compounds are the third and fourth examples of bisdesmosides of glycosidic acids having sugar linkages at C-3 of 3,11-dihydroxytetradecanoic acid (ipurolic acid) as well as at C-11. 相似文献
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996.
Misha Rosenbach Dedee F. Murrell Jean-Claude Bystryn Sam Dulay Sarah Dick Steve Fakharzadeh Russell Hall Neil J. Korman Julie Lin Joyce Okawa Amit G. Pandya Aimee S. Payne Mathew Rose David Rubenstein David Woodley Carmela Vittorio Benjamin B. Werth Erik A. Williams Lynne Taylor Andrea B. Troxel Victoria P. Werth 《The Journal of investigative dermatology》2009,129(10):2404-2410
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Relation between the painful shoulder and the cervical spine with narrow canal in patients without obvious radiculopathy. 总被引:3,自引:0,他引:3
K Mimori T Muneta H Komori A Okawa K Shinomiya 《Journal of shoulder and elbow surgery / American Shoulder and Elbow Surgeons ... [et al.]》1999,8(4):303-306
It is well known that cervical radiculopathy sometimes causes shoulder pain. Hypothesizing that the cause of painful shoulder is related to the cervical spine in the absence of obvious radiculopathy, we measured the anteroposterior diameter of the spinal canal and the range of motion of the cervical spine in patients with painful shoulder on lateral cervical radiographs of the spine. Painful shoulder was diagnosed in 76 patients (24 men and 52 women; mean age 57.6 years). Patients who reported neck pain or numbness of the upper limbs and patients with neurologic abnormalities were excluded from this study. A control group of 54 asymptomatic volunteers (27 men and 27 women; mean age 55.5 years) was formed. The difference in age between the patient group and the control group was not significant. The anteroposterior diameter of the spinal canal at C5 and C6 in the painful-shoulder group (C5: 12.74 mm; C6: 12.76 mm) was significantly narrower than in the control group (C5: 13.60 mm; C6: 13.79 mm). The range of motion was greatest at C4-5 and smallest at C2-3 in both groups; and there was no significant difference in the range of motion between the painful-shoulder group and the control group. When women only or men only were assessed, the results were nearly the same between groups. The cervical spine without obvious radiculopathy appears to be involved in patients with a painful shoulder. We speculate that the shoulder is affected by irritation of a cervical nerve root or referred pain. 相似文献