全文获取类型
收费全文 | 1414篇 |
免费 | 389篇 |
国内免费 | 13篇 |
专业分类
耳鼻咽喉 | 8篇 |
儿科学 | 89篇 |
妇产科学 | 103篇 |
基础医学 | 139篇 |
口腔科学 | 17篇 |
临床医学 | 754篇 |
内科学 | 248篇 |
皮肤病学 | 43篇 |
神经病学 | 77篇 |
特种医学 | 87篇 |
外科学 | 64篇 |
综合类 | 21篇 |
预防医学 | 97篇 |
眼科学 | 4篇 |
药学 | 24篇 |
中国医学 | 1篇 |
肿瘤学 | 40篇 |
出版年
2023年 | 5篇 |
2021年 | 13篇 |
2020年 | 9篇 |
2019年 | 17篇 |
2018年 | 86篇 |
2017年 | 99篇 |
2016年 | 116篇 |
2015年 | 104篇 |
2014年 | 103篇 |
2013年 | 134篇 |
2012年 | 75篇 |
2011年 | 79篇 |
2010年 | 83篇 |
2009年 | 110篇 |
2008年 | 92篇 |
2007年 | 86篇 |
2006年 | 80篇 |
2005年 | 59篇 |
2004年 | 66篇 |
2003年 | 32篇 |
2002年 | 32篇 |
2001年 | 14篇 |
2000年 | 17篇 |
1999年 | 16篇 |
1998年 | 16篇 |
1997年 | 23篇 |
1996年 | 19篇 |
1995年 | 10篇 |
1994年 | 10篇 |
1993年 | 10篇 |
1992年 | 20篇 |
1991年 | 10篇 |
1990年 | 12篇 |
1989年 | 19篇 |
1988年 | 19篇 |
1987年 | 13篇 |
1986年 | 7篇 |
1985年 | 16篇 |
1984年 | 9篇 |
1983年 | 5篇 |
1982年 | 3篇 |
1981年 | 5篇 |
1979年 | 5篇 |
1978年 | 8篇 |
1977年 | 11篇 |
1975年 | 4篇 |
1973年 | 5篇 |
1971年 | 4篇 |
1970年 | 4篇 |
1969年 | 6篇 |
排序方式: 共有1816条查询结果,搜索用时 15 毫秒
101.
Acute asthma in the pediatric emergency department 总被引:2,自引:0,他引:2
The management of children with acute asthma remains a difficult and challenging process. Although newer asthma medications are being developed, they are unlikely to have a large impact on the management of children with acute asthma. The leukotriene inhibitors are new anti-inflammatory agents for asthma and are beneficial for the treatment of patients with chronic asthma but have no therapeutic effect during the acute phase of an exacerbation. Older treatments, including the use of magnesium and heliox, have been revisited. Although some children with severe asthma may respond, these do not provide relief for most children with acute exacerbation. The new challenge for asthma care is finding ways to link children with their primary care providers so that regular asthma care can be established. The NHLBI recommends that children with asthma have regular visits with their primary care providers (e.g., four times a year). Regular care results in better adherence to medical and preventive management plans and improves the relationship between patients and physicians. Instituting an asthma action plan, which instructs families on when and how to begin therapy for an acute exacerbation, may prevent progression to a more severe condition. 相似文献
102.
Leaf AN Wolf BC Kirkwood JM Haselow RE 《Medical oncology (Northwood, London, England)》2000,17(1):47-51
This study of etoposide in thyroid cancer was designed to determine the activity and toxicity of etoposide in a variety of
inoperable, thyroid hormone insensitive, and radio-iodine resistant primary cancers of the thyroid. The patients were required
to have an ECOG performance status of at least 3 and no previous exposure to chemotherapy. The etoposide was given at a dose
of 140 mg/m2 daily for 3 days and every 3 weeks until progression. The study was closed after 18 months because of poor accrual. There
were no responses seen among the 10 patients accrued. The toxicity was primarily hematologic. There was no evidence of activity
of etoposide in thyroid carcinoma, although this study lacked significant power because of the poor accrual. 相似文献
103.
104.
H Strunk F Schweden A Teifke K Schunk H Schild 《R?ntgen-Bl?tter; Zeitschrift für R?ntgen-Technik und medizinisch-wissenschaftliche Photographie》1988,41(4):140-144
The CT image of renal metastases is described for 29 patients. The most frequent primary tumour was the bronchial carcinoma, followed by melanoma and cervical carcinoma. In 12 of 29 patients (41%) the metastases occurred bilaterally, in 17 (59%) unilaterally. 9/29 (31%) had solitary, 20/29 (69%) multiple renal metastases. In 19 (66%) these had a size of up to 3 cm and were situated intraparenchymally. Space-occupying growths up to a size of 10 cm which grew exophytically were seen in melanoma and carcinoma of the larynx and chorion. In the plain CT the metastases presented isodense or slightly hypodense in 25 of 27 examinations (93%). After application of contrast medium all presented hypodense with the exception of metastases of a chorionic carcinoma. 相似文献
105.
H Stotzka P Schneider M Burner P Strunk H Remschmidt I Dauer 《L'évolution Psychiatrique》1970,35(4):841-896
106.
107.
The number of cases in bile duct surgery has continuously increased since second world war. Correcting operation is necessary in 5 to 7% after cholecystectomy. Since 1973 more and more the endoscopic treatment takes place of surgery. Typical complications can be divided into two groups belonging to their manifestation. Early complications are due to an insufficient intraoperative diagnosis or injuries of bile tract. Late complications comprehend successive development of duct stenosis and cholangitis. The therapeutic possibilities of endoscopic papillotomy are directed only to the papilla and near-by sections of the choledochus, while surgical treatment is due to the more difficult performance of iatrogenic lesions. The indications to each method are shown and discussed by 138 surgical and 714 endoscopic treatments. 相似文献
108.
Strunk T Härtel C Schultz C 《Archives of disease in childhood. Fetal and neonatal edition》2004,89(4):F364-F366
There is a high incidence of hypoxic-ischaemic brain injury and intraventricular haemorrhage in newborn infants, particularly those born preterm. Many die during the newborn period or suffer permanent neurodevelopmental handicaps. Hypoxic brain injury develops over several hours and could potentially be influenced by intervention. At present, no drug exists that effectively prevents infant brain injury or ameliorates detrimental neurodevelopmental effects. The hypothesis is put forward that systemic administration of recombinant human erythropoietin positively affects the neurodevelopmental outcome of high risk preterm infants affected by brain injury. A multicentre, randomised, placebo controlled study is proposed to prospectively test this hypothesis. 相似文献
109.
Guilbert TW Morgan WJ Krawiec M Lemanske RF Sorkness C Szefler SJ Larsen G Spahn JD Zeiger RS Heldt G Strunk RC Bacharier LB Bloomberg GR Chinchilli VM Boehmer SJ Mauger EA Mauger DT Taussig LM Martinez FD;Prevention of Early Asthma in Kids Study Childhood Asthma Research Education Network 《Controlled clinical trials》2004,25(3):286-310
Pediatric asthma remains an important public health concern as its prevalence and cost to the health care system is rising. In order to promote innovative research in asthma therapies, the National Heart, Lung and Blood Institute created the Childhood Asthma Research and Education Network in 1999. As its first study, the steering committee of the Childhood Asthma Research and Education Network designed a randomized clinical trial to determine if persistent asthma could be prevented in children at a high risk to develop the disease. This communication presents the design of its first clinical trial, the Prevention of Asthma in Kids (PEAK) trial and the organization of the Childhood Asthma Research and Education Network that developed and implemented this trial. Studies of the natural history of asthma have shown that, in persistent asthma, the initial asthma-like symptoms and loss of lung function occur predominately during the first years of life. Therefore, in the Prevention of Asthma in Kids study, children 2 and 3 years old with a positive asthma predictive index were randomized to twice daily treatment with fluticasone 88 microg or placebo via metered-dose inhaler and Aerochamber for 2 years. The double blind treatment period was followed by a 1-year observational period. Lung function was measured by spirometry and oscillometry technique at 4-month intervals throughout the study. Bronchodilator reversibility and exhaled nitric oxide (ENO) studies were performed at the end of the treatment and observation periods. The primary outcome measure was the number of asthma-free days. Other secondary outcomes included number of exacerbations, use of asthma medications and lung function. These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity. 相似文献
110.
Surging growth in preferred provider organization (PPO) participation has been fueled by migration away from the undesirable features of health maintenance organizations (HMOs). While employers, consumers, and providers seem to know what it is they do not want from HMOs, the advantages offered by PPO design are not so clear. This is attributable in part to difficulties in determining what a PPO arrangement actually is. But it may also reflect a lack of strong evidence that PPOs control costs, provide active care management, or promote quality improvement. 相似文献