全文获取类型
收费全文 | 906篇 |
免费 | 46篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 28篇 |
妇产科学 | 23篇 |
基础医学 | 69篇 |
口腔科学 | 15篇 |
临床医学 | 105篇 |
内科学 | 249篇 |
皮肤病学 | 12篇 |
神经病学 | 22篇 |
特种医学 | 115篇 |
外科学 | 76篇 |
综合类 | 30篇 |
预防医学 | 119篇 |
眼科学 | 4篇 |
药学 | 62篇 |
肿瘤学 | 32篇 |
出版年
2019年 | 6篇 |
2018年 | 16篇 |
2017年 | 11篇 |
2016年 | 5篇 |
2015年 | 14篇 |
2014年 | 15篇 |
2013年 | 28篇 |
2012年 | 21篇 |
2011年 | 30篇 |
2010年 | 36篇 |
2009年 | 35篇 |
2008年 | 28篇 |
2007年 | 46篇 |
2006年 | 47篇 |
2005年 | 31篇 |
2004年 | 39篇 |
2003年 | 27篇 |
2002年 | 31篇 |
2001年 | 22篇 |
2000年 | 20篇 |
1999年 | 17篇 |
1998年 | 31篇 |
1997年 | 26篇 |
1996年 | 40篇 |
1995年 | 24篇 |
1994年 | 19篇 |
1993年 | 21篇 |
1992年 | 13篇 |
1991年 | 10篇 |
1990年 | 18篇 |
1989年 | 20篇 |
1988年 | 29篇 |
1987年 | 20篇 |
1986年 | 23篇 |
1985年 | 17篇 |
1984年 | 17篇 |
1983年 | 15篇 |
1982年 | 12篇 |
1981年 | 15篇 |
1980年 | 9篇 |
1979年 | 3篇 |
1978年 | 8篇 |
1977年 | 9篇 |
1976年 | 8篇 |
1975年 | 6篇 |
1974年 | 3篇 |
1973年 | 3篇 |
1971年 | 4篇 |
1970年 | 3篇 |
1969年 | 2篇 |
排序方式: 共有962条查询结果,搜索用时 109 毫秒
61.
62.
Serum dopamine-beta-hydroxylase (DBH) activity was measured in a heterogeneous sample of 290 outpatients awaiting medical, surgical, or psychiatric appointments at a Veterans Administration Hospital. All patients were assessed for depressive symptomatology by the Zung Self-Rating Depression Scale (SDS) and for elevated diastolic blood pressure (BP greater than or equal to 90 mm Hg). Elevated DBH activity was associated with SDS scores greater than or equal to 60. No statistical association was found between DBH activity and diastolic BP. Two pharmacological agents, alpha-methyl-DOPA and minor tranquilizers, also were associated with significant alterations in serum DBH activity. 相似文献
63.
Schellekens SM Ananthakrishnan S Stolk WA Habbema JD Ravi R 《Transactions of the Royal Society of Tropical Medicine and Hygiene》2005,99(1):75-77
Many countries have implemented mass drug administration programmes to eliminate lymphatic filariasis, but few have also implemented morbidity management programmes to help patients with chronic lymphoedema or hydrocele due to the infection. A study was carried out to assess current morbidity management by physicians in Pondicherry, India. Fifty-two physicians were interviewed, using a semi-structured questionnaire. For the management of hydrocele, all physicians referred hydrocele patients for surgery and 83% prescribed diethylcarbamazine (DEC). For the management of chronic lymphoedema patients, most doctors (75%) prescribed DEC and 56% mentioned the possibility of surgery. Only 10% of the physicians gave advice about limb hygiene, although recent research has shown the importance of hygiene measures to prevent further progression of lymphoedema. For the management of lymphoedema patients presenting with acute attacks, all physicians prescribed DEC and antibiotics and only 15% gave advice about limb hygiene. We conclude that limb hygiene instruction for home care should be more strongly emphasised to optimize management of lymphoedema patients in Pondicherry. 相似文献
64.
65.
66.
67.
Estrogen receptor alpha gene polymorphisms are associated with estradiol levels in postmenopausal women 总被引:5,自引:0,他引:5
Schuit SC de Jong FH Stolk L Koek WN van Meurs JB Schoofs MW Zillikens MC Hofman A van Leeuwen JP Pols HA Uitterlinden AG 《European journal of endocrinology / European Federation of Endocrine Societies》2005,153(2):327-334
OBJECTIVE: Postmenopausal estradiol (E(2)) levels vary widely between individuals and this variation is an important determinant of diseases such as osteoporosis. It has been suggested that the estrogen receptor alpha (ESR1) gene may influence peripheral E(2) levels, but the role of common sequence variations in the ESR1 gene is unclear. METHODS: In 631 postmenopausal women and 528 men from the Rotterdam Study, a population-based, prospective cohort study of individuals aged 55 years and over, ESR1 PvuII-XbaI haplotypes were determined and correlated with plasma E2 levels. RESULTS: In women, haplotype 1 (T-A) was significantly associated with an allele-dose-dependent decrease in E(2). After adjusting for age, body mass index, years since menopause and testosterone levels, plasma E(2) levels decreased by 1.90 pmol/l per allele copy of this haplotype (P < 0.05). Extreme genotypes, representing 23 and 27% of the population, varied by 3.93 pmol/l. No association with plasma testosterone was observed. In a subset of 446 women, no association of genotype with plasma concentrations of dehydroepiandrosterone sulfate, androstenedione or estrone was seen. In men, none of the sex hormone levels was associated with the ESR1 PvuII-XbaI haplotypes. CONCLUSION: We have demonstrated a role for genetic variations in the ESR1 gene in determining post-menopausal E(2) levels in women. 相似文献
68.
69.
Past, present, and future of annexin A5: from protein discovery to clinical applications. 总被引:15,自引:0,他引:15
Hendrikus H Boersma Bas L J H Kietselaer Leo M L Stolk Abdelkader Bennaghmouch Leonard Hofstra Jagat Narula Guido A K Heidendal Chris P M Reutelingsperger 《Journal of nuclear medicine》2005,46(12):2035-2050
In this article, we review the clinical aspects of imaging with the programmed cell-detecting protein annexin A5 (anxA5). AnxA5 binds to phosphatidylserine, which is one of the "eat me" signals at the surface of the apoptotic cell. This biologic property forms the basis for the development of anxA5 as a diagnostic tool. Within this context, the clinical relevance, limitations, and future perspectives of this approach of visualizing cell death are discussed in this article, as are other potential applications of anxA5. Furthermore, the biologic properties and the radiopharmaceutical, pharmacologic, and biodistribution aspects of anxA5 are reviewed and discussed in this article. Radiolabeled anxA5 bears the promise of becoming a clinically applied radiopharmaceutical with potential applications in cardiology and oncology. Visualization of cell death is important in pathologies such as myocardial infarction, atherosclerosis, and cancer. Furthermore, radiolabeled anxA5 may be developed as a tool for monitoring cell death-inducing or cell death-preventing therapies. In addition, experiences with radiolabeled anxA5 open novel avenues for drug targeting with anxA5 as a biologic "cruise missile." 相似文献
70.
Alpha1-antitrypsin deficiency. 7: Computed tomographic imaging in alpha1-antitrypsin deficiency
下载免费PDF全文
![点击此处可从《Thorax》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Computed tomographic scanning may replace lung function tests as the golden standard for assessing the response to known and novel treatments for alpha1-antitrypsin deficiency. 相似文献