全文获取类型
收费全文 | 2006篇 |
免费 | 87篇 |
国内免费 | 10篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 145篇 |
妇产科学 | 62篇 |
基础医学 | 232篇 |
口腔科学 | 51篇 |
临床医学 | 122篇 |
内科学 | 273篇 |
皮肤病学 | 43篇 |
神经病学 | 102篇 |
特种医学 | 183篇 |
外国民族医学 | 1篇 |
外科学 | 264篇 |
综合类 | 55篇 |
预防医学 | 161篇 |
眼科学 | 8篇 |
药学 | 67篇 |
中国医学 | 1篇 |
肿瘤学 | 324篇 |
出版年
2021年 | 13篇 |
2019年 | 12篇 |
2018年 | 15篇 |
2017年 | 16篇 |
2016年 | 22篇 |
2015年 | 32篇 |
2014年 | 24篇 |
2013年 | 46篇 |
2012年 | 55篇 |
2011年 | 63篇 |
2010年 | 45篇 |
2009年 | 65篇 |
2008年 | 57篇 |
2007年 | 63篇 |
2006年 | 75篇 |
2005年 | 71篇 |
2004年 | 77篇 |
2003年 | 79篇 |
2002年 | 69篇 |
2001年 | 63篇 |
2000年 | 69篇 |
1999年 | 69篇 |
1998年 | 75篇 |
1997年 | 74篇 |
1996年 | 69篇 |
1995年 | 47篇 |
1994年 | 51篇 |
1993年 | 54篇 |
1992年 | 31篇 |
1991年 | 31篇 |
1990年 | 38篇 |
1989年 | 45篇 |
1988年 | 45篇 |
1987年 | 54篇 |
1986年 | 49篇 |
1985年 | 37篇 |
1984年 | 28篇 |
1983年 | 20篇 |
1982年 | 34篇 |
1981年 | 13篇 |
1980年 | 21篇 |
1979年 | 18篇 |
1978年 | 12篇 |
1977年 | 14篇 |
1976年 | 12篇 |
1975年 | 12篇 |
1973年 | 18篇 |
1972年 | 9篇 |
1971年 | 14篇 |
1968年 | 9篇 |
排序方式: 共有2103条查询结果,搜索用时 62 毫秒
51.
52.
The effects of plasma exchange performed every two weeks for 31 months in combination with diet and drug therapy were studied in a patient with receptor-defective homozygous familial hypercholesterolemia. Coronary angiography performed three years prior to commencing plasma exchange was compared to angiography 31 months after starting the program. Comparison of the angiograms taken six years apart showed no progression of coronary atheroma in the main left coronary artery in which a 30% narrowing was originally seen. An internal mammary artery-coronary artery bypass remained widely patent and showed no development of atherosclerosis. Plasma cholesterol levels were reduced 46% by plasma exchange, diet and drug compared to diet and drug alone. Achilles tendon xanthoma diminished significantly. It appears that plasma exchange combined with diet and drug therapy, while not producing regression of existing atheromatous lesions, does retard or prevent further progression. 相似文献
53.
I M Spitz P Lavie N Calderon C R Gordon A Oksenberg M Ron N Laufer Y Livshin J Schenker 《Metabolism: clinical and experimental》1982,31(1):10-13
Prolactin (PRL) secretion has been measured during sleep and following TRH administration in 8 patients aged 24-39 yr with seminiferous tubule failure and 36 controls. Basal LH levels were 25.7 +/- 14.7 mIU/ml in the patients compared to 11.5 +/- 4.2 mIU/ml in the controls (p less than 0.01) Corresponding FSH levels were 26.2 +/- 10.7 mIU/ml and 5.9 +/- 2.1 mIU/ml (p less than 0.001) Mean estradiol 17B and testosterone levels were similar in the 2 groups. The mean PRL secretion during sleep was 16.5 +/- 11.7 ng/ml in the patients and not different in 11 of the controls (12.4 +/- 3.2 ng/ml). One patient had a mean nocturnal PRL concentration of 44.1 ng/ml. In both groups, the mean sleep related PRL concentration was greater than that during waking hours. The average number of peaks in the 2 groups was similar. In the same patients, the peak PRL response to TRH (200 ug IV) was 81.9 +/- 18.8 ng/ml as compared to 32.1 +/- 10.7 ng/ml in the controls (p less than 0.001). It is concluded that PRL concentrations following pharmacological stimulation are increased in seminiferous tubule failure, whereas levels are normal in relation to the physiological stimulus of sleep. 相似文献
54.
55.
A multicenter study of hospitalization in rheumatoid arthritis. Frequency, medical-surgical admissions, and charges 总被引:1,自引:0,他引:1
F Wolfe S M Kleinheksel P W Spitz D P Lubeck J F Fries D Y Young D Mitchell S Roth 《Arthritis and rheumatism》1986,29(5):614-619
During 1981, 123 of 816 patients (15.1%) with rheumatoid arthritis were hospitalized 160 times because of the disease. The mean length of hospitalization was 13.1 days, and the cost $7,845. Surgery accounted for 54.4% of admissions, but 69.2% of costs. The average cost for total joint surgery was $12,287. Most medical admissions (46.6%) were for the diagnosis or treatment of articular disease, but 42.5% were for treatment of side effects of therapy, and 11.0% for complications of RA. The most commonly performed surgical procedures included reconstructive surgery of the hand/wrist (n = 35) and foot (n = 22), followed by total knee replacement (n = 18). 相似文献
56.
57.
The relative importance of thrombin inhibition and factor Xa inhibition to the antithrombotic effects of heparin 总被引:4,自引:1,他引:4
The relative importance of antithrombin and anti-factor Xa activities of heparin fractions required to achieve optimal antithrombotic effects is unknown. To study this, we measured the effects of standard heparin, an octasaccharide heparin fraction (anti-factor Xa activity only), and dermatan sulfate (antithrombin activity only) on the prevention of thrombosis and related this to their anticoagulant effects in vivo in rabbits. Thrombosis was measured as the incorporation of 125I- fibrinogen into tissue thromboplastin-induced thrombi using a Wessler- type model. Ex vivo changes in thrombin clotting time (TCT) were used as an index of antithrombin activity, and a chromogenic anti-factor Xa assay was used to measure anti-factor Xa activity. In addition, the ability of the three sulfated polysaccharides to simultaneously inhibit the generation of thrombin activity and to enhance the inactivation of the factor Xa added to initiate thrombin generation in plasma was determined. Standard heparin, in a dose of 10 anti-factor Xa U/kg, inhibited thrombus formation by 90%, prolonged the TCT by two seconds, and resulted in an anti-factor Xa level of 0.32 U/mL. The octasaccharide heparin fraction, in a dose of 10 anti-factor Xa U/kg, inhibited thrombus formation by 41%, had no effect on the TCT, and resulted in an anti-factor Xa level of 0.28 U/mL. Higher doses of the octasaccharide resulted in a further increase in the anti-factor Xa levels but had no further effect on thrombus formation. Dermatan sulfate, in a dose of 500 micrograms/kg, inhibited thrombus formation by 95%, but had no affect on the TCT. These results indicate that the antithrombotic effect achieved by inhibiting factor Xa is limited and that better antithrombotic effects are achieved by heparin or heparin- like substances capable of influencing the inactivation and/or the generation of thrombin. 相似文献
58.
59.
60.
A Bahrami Y Rassi N Maleki MA Oshaghi M Mohebali MR Yagoobi-Ershadi S Rafizadeh 《亚太热带病杂志(英文版)》2014,4(2):110-114