全文获取类型
收费全文 | 254篇 |
免费 | 5篇 |
国内免费 | 1篇 |
专业分类
儿科学 | 2篇 |
妇产科学 | 9篇 |
基础医学 | 32篇 |
口腔科学 | 30篇 |
临床医学 | 12篇 |
内科学 | 47篇 |
皮肤病学 | 5篇 |
神经病学 | 17篇 |
特种医学 | 3篇 |
外科学 | 17篇 |
预防医学 | 25篇 |
眼科学 | 6篇 |
药学 | 39篇 |
中国医学 | 11篇 |
肿瘤学 | 5篇 |
出版年
2023年 | 1篇 |
2022年 | 1篇 |
2021年 | 1篇 |
2020年 | 4篇 |
2019年 | 5篇 |
2018年 | 4篇 |
2017年 | 1篇 |
2016年 | 3篇 |
2015年 | 8篇 |
2014年 | 7篇 |
2013年 | 16篇 |
2012年 | 23篇 |
2011年 | 15篇 |
2010年 | 14篇 |
2009年 | 15篇 |
2008年 | 14篇 |
2007年 | 21篇 |
2006年 | 23篇 |
2005年 | 20篇 |
2004年 | 16篇 |
2003年 | 22篇 |
2002年 | 14篇 |
2001年 | 2篇 |
2000年 | 1篇 |
1998年 | 2篇 |
1997年 | 1篇 |
1995年 | 1篇 |
1983年 | 1篇 |
1981年 | 1篇 |
1972年 | 1篇 |
1960年 | 1篇 |
1956年 | 1篇 |
排序方式: 共有260条查询结果,搜索用时 15 毫秒
81.
Wiyada Kaewkrud Hideaki Otsuka Somsak Ruchirawat Tripetch Kanchanapoom 《Journal of natural medicines》2007,61(4):449-451
A new megastigmane diglycoside, leeaoside, was isolated along with four known compounds; benzyl O-α-l-rhamnopyranosyl-(1 → 6)-β-d-glucopyranoside, quercetin 3-O-α-l-rhamnopyranoside, myricetin 3-O-α-l-rhamnopyranoside and citroside A from the leaves of Leea thorelli. The structure determinations were based on physical data and spectroscopic evidence. 相似文献
82.
83.
84.
Tam JS Capeding MR Lum LC Chotpitayasunondh T Jiang Z Huang LM Lee BW Qian Y Samakoses R Lolekha S Rajamohanan KP Narayanan SN Kirubakaran C Rappaport R Razmpour A Gruber WC Forrest BD;Pan-Asian CAIV-T Pediatric Efficacy Trial Network 《The Pediatric infectious disease journal》2007,26(7):619-628
BACKGROUND: This study was designed to evaluate the efficacy and safety of cold-adapted influenza vaccine, trivalent (CAIV-T) against culture-confirmed influenza in children 12 to <36 months of age during 2 consecutive influenza seasons at multiple sites in Asia. METHODS: In year 1, 3174 children 12 to <36 months of age were randomized to receive 2 doses of CAIV-T (n = 1900) or placebo (n = 1274) intranasally > or =28 days apart. In year 2, 2947 subjects were rerandomized to receive 1 dose of CAIV-T or placebo. RESULTS: Mean age at enrollment was 23.5 +/- 7.4 months. In year 1, efficacy of CAIV-T compared with placebo was 72.9% [95% confidence interval (CI): 62.8-80.5%] against antigenically similar influenza subtypes, and 70.1% (95% CI: 60.9-77.3%) against any strain. In year 2, revaccination with CAIV-T demonstrated significant efficacy against antigenically similar (84.3%; 95% CI: 70.1-92.4%) and any (64.2%; 95% CI: 44.2-77.3%) influenza strains. In year 1, fever, runny nose/nasal congestion, decreased activity and appetite, and use of fever medication were more frequent with CAIV-T after dose 1. Runny nose/nasal congestion after dose 2 (year 1) and dose 3 (year 2) and use of fever medication after dose 3 (year 2) were the only other events reported significantly more frequently in CAIV-T recipients. CONCLUSIONS: CAIV-T was well tolerated and effective in preventing culture-confirmed influenza illness over multiple and complex influenza seasons in young children in Asia. 相似文献
85.
Sirivongrangson P Bollen LJ Chaovavanich A Suksripanich O Virapat P Tunthanathip P Ausavapipit J Lokpichat S Siangphoe U Jirarojwat N Pobkeeree V Supawitkul S Tappero JW Levine WC 《Sexually transmitted diseases》2007,34(2):104-107
OBJECTIVES: Although cervical cancer is an AIDS-defining illness, few HIV-infected women are routinely screened for cervical cancer in Thailand. We screened HIV-infected women for cervical cancer as a component of HIV care and assessed high-risk human papillomavirus (HPV) and cervical cancer prevalence. METHODS: From July 2003 through February 2004, HIV-infected women attending either an infectious disease clinic or a sexually transmitted infection (STI) clinic in Bangkok were tested for high-risk HPV types by Hybrid Capture 2 and screened for cervical cancer by Pap test; those with abnormal cervical cytology were referred for diagnosis and treatment. RESULTS: Two hundred ten HIV-infected women at an infectious disease clinic (n = 150) and an STI clinic (n = 60) received cervical cancer screening. The high-risk HPV prevalence was 38.6% and the prevalence of abnormal cervical cytology was 20.4%. Abnormal cervical cytology and high-risk HPV detection were associated (P < 0.001). We received pathology reports for 23 (53.5%) of 43 women, including all those with a Pap test showing high-grade squamous intraepithelial lesions; the cervical cancer prevalence was 1.9% (4 of 210; 95% confidence interval, 0.5-4.8%). CONCLUSION: The estimated prevalence of high-risk HPV and cervical cancer among HIV-infected women in Thailand was high. This emphasizes the need to integrate cervical cancer screening into HIV care. 相似文献
86.
Satayavivad J Watcharasit P Khamkong P Tuntawiroon J Pavaro C Ruchirawat S 《Acta tropica》2004,89(3):343-349
2,3-bis(Trifluoromethyl)-4-(3-hydroxyquinuclidinylquinoline) or MC(1) is a new synthetic compound with potent antimalarial activity in vitro and in vivo studies. The IC(50) values of MC(1) and chloroquine in in vitro culture of Plasmodium falciparum are 7.0x10(-8) and 6.06x10(-7)M, respectively. In an in vivo study using Plasmodium berghei infected mice as the test model, the survival time of the infected mice without drug treatment was 6.00+0.58 days. Chloroquine and MC(1) at an equal dose of 7.5mg/kg, orally administered once daily for 4 days, prolonged the survival time of the infected mice from 6 to 14 days, and more than 28 days, respectively. At the doses that exhibit potent antimalarial activity in vivo, there are no observable toxic effects. Preliminary studies of the pharmacodynamic activity of this newly synthesized compound revealed that at the doses which exhibit potent antimalarial activity, there is no alteration in motor activity such as distance traveled, rotational behavior, and stereotypic activity. The blood glucose was not significantly altered. In the spontaneous beating, isolated right atria of mice, MC(1) exhibits direct negative chronotropism at high concentrations (10(-4)M). This effect is augmented in hyper-K(+) bathing solution. A direct negative chronotropic effect was also observed when mefloquine at 5x10(-5)M was used. Preliminary pharmacodynamic study suggested that MC(1) is a potential new antimalarial drug that should be studied further. 相似文献
87.
88.
Tharavichitkul E Sivasomboon C Wanwilairat S Lorvidhaya V Sukthomya V Chakrabhandu S Lookkaew S Chitapanarux I Galalae R 《Journal of radiation research》2012,53(2):313-318
This study was performed to evaluate the feasibility of magnetic resonance imaging (MRI) in the treatment planning of image-guided brachytherapy for cervical carcinoma. Seventeen consecutive patients with locally advanced cervical cancer were enrolled in the study. Fifteen patients could be evaluated. When comparing the tumor at diagnosis (GTV-Dx) and the tumor at the first brachytherapy (GTV-BT), 11 of 15 patients showed a tumor regression of more than 80% while only four patients had less than 80% tumor regression. The mean D90 of HR-CTV and the calculated D2cc of the bladder, rectum, and sigmoid were 99.2 ± 11 Gy, 87.7 ± 5.7 Gy, 68.4 ± 5.4 Gy and 70.3 ± 6.8 Gy, respectively. No grade 3-4 acute toxicity was observed. The MRI can be a valuable tool for evaluating tumor response after external beam radiotherapy (EBRT) and is very helpful for prognosis prediction by residual GTV evaluation. Furthermore, MRI-guided brachytherapy allowed us to optimize the dose for both the target volumes and the OARs. 相似文献
89.
90.
Rungrot Cherdtrakulkiat Apilak Worachartcheewan Srisurang Tantimavanich Ratana Lawung Nujarin Sinthupoom Supaluk Prachayasittikul Somsak Ruchirawat Virapong Prachayasittikul 《Drug development research》2020,81(1):127-135
Methicillin-resistant Staphylococcus aureus (MRSA) infection has been considered to be one of global health problems due to limited classes of effective antimicrobial drugs. Herein, 8-hydroxyquinoline (8HQ) and its derivatives ( 1-7 ) were investigated for their anti-MRSA and antioxidant activities. Cloxyquin ( 2 ), a halogenated 8HQ, exerted the highest antimicrobial activity (MIC50 ≤ 5.57 μM) with high safety index, whereas an amino-derivative 7 showed the strongest antioxidant activity. Additionally, quantitative structure-activity relationship (QSAR) study demonstrated that mass, polarizability, topological charge, and van der Waals volume are essential properties governing the anti-MRSA activity. Taken together, cloxyquin was highlighted as a promising compound for further development as a novel anti-MRSA agent. QSAR findings would also benefit for further rational design of novel 8HQ-based compounds to combat the MRSA resistance. 相似文献