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41.
42.
WISP3 and RhoC guanosine triphosphatase cooperate in the development of inflammatory breast cancer
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Celina?G?Kleer Yanhong?Zhang Quintin?Pan Gary?Gallagher Mei?Wu Zhi-Fen?Wu Sofia?D?MerajverEmail author 《Breast cancer research : BCR》2003,6(2):R110
Background
Inflammatory breast cancer (IBC) is the most lethal form of locally advanced breast cancer. We found concordant and consistent alterations of two genes in 90% of IBC tumors when compared with stage-matched non-IBC tumors: overexpression of RhoC guanosine triphosphatase and loss of WNT-1 induced secreted protein 3 (WISP3). Further work revealed that RhoC is a transforming oncogene for human mammary epithelial (HME) cells. Despite the aggressiveness of the RhoC-driven phenotype, it does not quantitatively reach that of the true IBC tumors. We have demonstrated that WISP3 has tumor growth and angiogenesis inhibitory functions in IBC. We proposed that RhoC and WISP3 cooperate in the development of IBC. 相似文献43.
Liliana Leite Inês Boticas Miguel Navarro Luís Nobre Joo Bessa Fernando Cunha Pedro Neves Raúl Fangueiro 《Materials》2022,15(18)
Control of food spoilage is a critical concern in the current world scenario, not only to ensure the quality and safety of food but also to avoid the generation of food waste. This paper evaluates a dual-sensor strategy using six different pH indicators stamped on cardboard for the detection of spoilage in three different foods: beef, salmon, and strawberries. After function validation and formulation optimizations in the laboratory, the halochromic sensors methyl orange and bromocresol purple 2% (w/v) were stamped on cardboard and, in contact with the previously mentioned foods, were able to produce an easily perceptible signal for spoilage by changing color. Additionally, when it comes to mechanical characterization the inks showed high abrasion (>100 cycles) and adhesion resistance (>91%). 相似文献
44.
Sofia Tikhanova Anna Seroglazova Maria Chebanenko Vladimir Nevedomskiy Vadim Popkov 《Materials》2022,15(22)
Nanostructured hexagonal rare-earth orthoferrites (h-RfeO3, R = Sc, Y, Tb-Lu) are well known as a highly effective base for visible-light-driven heterojunction photocatalysts. However, their application is limited by metastability, leading to difficulties in synthesis due to the irreversible transformation to a stable orthorhombic structure. In this work, we report on a simple route to the stabilization of h-YbFeO3 nanocrystals by the synthesis of multiphase nanocomposites with titania additives. The new I-type heterojunction nanocomposites of o-YbFeO3/h-YbFeO3/r-TiO2 were obtained by the glycine–nitrate solution combustion method with subsequent heat treatment of the products. An increase in the mole fraction of the h-YbFeO3 phase in nanocomposites was found with the titanium addition, indicating its stabilizing effect via limiting mass transfer over heat treatment. The complex physicochemical analysis shows multiple contacts of individual nanocrystals of o-YbFeO3 (44.4–50.6 nm), h-YbFeO3 (7.5–17.6 nm), and rutile r-TiO2 (~5 nm), confirming the presence of the heterojunction structure in the obtained nanocomposite. The photocatalytic activity of h-YbFeO3/o-YbFeO3/r-TiO2 nanocomposites was evaluated by the photo-Fenton degradation of the methyl violet under visible light (λ ≥ 400 nm). It was demonstrated that the addition of 5 mol.% of TiO2 stabilizes h-YbFeO3, which allowed us to achieve a 41.5 mol% fraction, followed by a three-time increase in the photodecomposition rate constant up to 0.0160 min−1. 相似文献
45.
Jean Damascene Makuza Dahn Jeong Mawuena Binka Prince Asumadu Adu Georgine Cua Amanda Yu Hctor Alexander Velsquez García Maria Alvarez Stanley Wong Sofia Bartlett Mohammad Ehsanul Karim Eric M. Yoshida Alnoor Ramji Mel Krajden Naveed Zafar Janjua 《Viruses》2022,14(11)
Data on the contribution of hepatitis B virus (HBV) infection and related comorbidities to liver-related mortality in Canada are limited. We assessed the concurrent impact of HBV infection, non-alcoholic fatty liver disease (NAFLD), and hepatitis C virus (HCV) coinfection on liver-related deaths in British Columbia (BC), Canada. We used data from the BC Hepatitis Testers Cohort (BC-HTC). We used Fine–Gray multivariable sub-distributional hazards models to assess the effect of HBV, NAFLD, and HCV coinfection on liver-related mortality, while adjusting for confounders and competing mortality risks. The liver-related mortality rate was higher among people with HBV infection than those without (2.57 per 1000 PYs (95%CI: 2.46, 2.69) vs. 0.62 per 1000 PYs (95%CI: 0.61, 0.64), respectively). Compared with the HBV negative groups, HBV infection was associated with increased liver-related mortality risk in almost all of the subgroups: HBV mono-infection (adjusted subdistribution hazards ratio (asHR) of 3.35, 95% CI 3.16, 3.55), NAFLD with HBV infection, (asHR 12.5, 95% CI 7.08, 22.07), and HBV/HCV coinfection (asHR 8.4, 95% CI 7.62, 9.26). HBV infection is associated with a higher risk of liver-related mortality, and has a greater relative impact on people with NAFLD and those with HCV coinfection. The diagnosis and treatment of viral and fatty liver disease are required to mitigate liver-related morbidity and mortality. 相似文献
46.
María Fernanda Olivares Barraza Rodrigo A Fasce Francisco Nogareda Perrine Marcenac Natalia Vergara Mallegas Patricia Bustos Alister Sergio Loayza Anna N. Chard Carmen Sofia Arriola Paula Couto Christian García Calavaro Angel Rodriguez David E. Wentworth Cristbal Cuadrado Eduardo Azziz-Baumgartner 《MMWR. Morbidity and mortality weekly report》2022,71(43):1353
47.
Joo P. Caldas Sofia R. Valdoleiros Sandra Rebelo Margarida Tavares 《Emerging infectious diseases》2022,28(12):2516
We report a case of monkeypox in a physician after an occupational needlestick injury from a pustule. This case highlights risk for occupational transmission and manifestations of the disease after percutaneous transmission: a short incubation period, followed by a solitary lesion at the injured site and later by systemic symptoms. 相似文献
48.
Sofia Pinto Teresa Correia-de-S Benedita Sampaio-Maia Carla Vasconcelos Pedro Moreira Joana Ferreira-Gomes 《Nutrients》2022,14(20)
Attention Deficit Hyperactivity Disorder (ADHD) is one of the most common neurodevelopmental disorders in childhood, affecting ~7% of children and adolescents. Given its adverse health outcomes and high healthcare and societal costs, other treatment options beyond pharmacotherapy have been explored. Case-control studies have shown that dietary patterns may influence the risk of ADHD, and specific dietary interventions have been proposed as coadjuvant treatments in this disorder. These include nutritional supplements, gut microbiome-targeted interventions with biotics, and elimination diets. The purpose of this review is to examine which dietary patterns are most associated with ADHD and to summarize the existing evidence for the clinical use of dietary interventions. The literature showed that non-healthy dietary patterns were positively associated with ADHD, whereas healthy patterns were negatively associated. As for nutritional supplements, only vitamin D and vitamin D + magnesium appeared to improve ADHD symptoms when baseline levels of vitamin D were insufficient/deficient. Regarding biotics, evidence was only found for Lactobacillus rhamnosus GG and for multi-species probiotic supplementation. Elimination diets have scarce evidence and lead to nutritional deficiencies, so caution is advised. Overall, more robust scientific evidence is required for these dietary interventions to be implemented as part of ADHD therapy. 相似文献
49.
Kiriakos Stefanidis Dorothea Tsatsou Dimitrios Konstantinidis Lazaros Gymnopoulos Petros Daras Saskia Wilson-Barnes Kathryn Hart Vronique Cornelissen Elise Decorte Elena Lalama Andreas Pfeiffer Maria Hassapidou Ioannis Pagkalos Anagnostis Argiriou Konstantinos Rouskas Stelios Hadjidimitriou Vasileios Charisis Sofia Balula Dias Jos Alves Diniz Gonalo Telo Hugo Silva Alex Bensenousi Kosmas Dimitropoulos 《Nutrients》2022,14(20)
AI-based software applications for personalized nutrition have recently gained increasing attention to help users follow a healthy lifestyle. In this paper, we present a knowledge-based recommendation framework that exploits an explicit dataset of expert-validated meals to offer highly accurate diet plans spanning across ten user groups of both healthy subjects and participants with health conditions. The proposed advisor is built on a novel architecture that includes (a) a qualitative layer for verifying ingredient appropriateness, and (b) a quantitative layer for synthesizing meal plans. The first layer is implemented as an expert system for fuzzy inference relying on an ontology of rules acquired by experts in Nutrition, while the second layer as an optimization method for generating daily meal plans based on target nutrient values and ranges. The system’s effectiveness is evaluated through extensive experiments for establishing meal and meal plan appropriateness, meal variety, as well as system capacity for recommending meal plans. Evaluations involved synthetic data, including the generation of 3000 virtual user profiles and their weekly meal plans. Results reveal a high precision and recall for recommending appropriate ingredients in most user categories, while the meal plan generator achieved a total recommendation accuracy of 92% for all nutrient recommendations. 相似文献
50.
Emily J. Aston Michael G. Wallach Aarthi Narayanan Sofia Egaa-Labrin Rodrigo A. Gallardo 《Viruses》2022,14(7)
The novel severe acute respiratory syndrome (SARS) coronavirus, SARS-CoV-2, is responsible for the global COVID-19 pandemic. Effective interventions are urgently needed to mitigate the effects of COVID-19 and likely require multiple strategies. Egg-extracted antibody therapies are a low-cost and scalable strategy to protect at-risk individuals from SARS-CoV-2 infection. Commercial laying hens were hyperimmunized against the SARS-CoV-2 S1 protein using three different S1 recombinant proteins and three different doses. Sera and egg yolk were collected at three and six weeks after the second immunization for enzyme-linked immunosorbent assay and plaque-reduction neutralization assay to determine antigen-specific antibody titers and neutralizing antibody titers, respectively. In this study we demonstrate that hens hyperimmunized against the SARS-CoV-2 recombinant S1 and receptor binding domain (RBD) proteins produced neutralizing antibodies against SARS-CoV-2. We further demonstrate that antibody production was dependent on the dose and type of antigen administered. Our data suggests that antibodies purified from the egg yolk of hyperimmunized hens can be used as immunoprophylaxis in humans at risk of exposure to SARS-CoV-2. 相似文献