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91.
Van den Ende CH; Vliet Vlieland TP; Munneke M; Hazes JM 《Rheumatology (Oxford, England)》1998,37(6):677-687
The aim of this systematic review was to determine the effectiveness of
dynamic exercise therapy in improving joint mobility, muscle strength,
aerobic capacity and daily functioning in patients with rheumatoid
arthritis (RA). In addition, possible unwanted effects such as an increase
in pain, disease activity and radiological progression were studied. A
computer-aided search of the MEDLINE, Embase and SCISEARCH databases was
performed to identify controlled trials on the effect of exercise therapy.
Randomized trials were selected on the effect of dynamic exercise therapy
in RA patients with an exercise programme fulfilling the following
criteria: (a) intensity level such that heart rates exceeded 60% of maximal
heart rate during at least 20 min; (b) exercise frequency > or = 2 a
week; and (c) duration of intervention > or = 6 weeks. Two blinded
reviewers independently selected eligible studies, rated the methodological
quality and extracted data. Six out of 30 identified controlled trials met
the inclusion criteria. Four of the six included studies fulfilled > or
= 7/10 methodological criteria. Because of heterogeneity in outcome
measures, data could not be pooled. The results suggest that dynamic
exercise therapy is effective in increasing aerobic capacity and muscle
strength. No detrimental effects on disease activity and pain were
observed. The effects of dynamic exercise therapy on functional ability and
radiological progression are unclear. It is concluded that dynamic exercise
therapy has a positive effect on physical capacity. Research on the
long-term effect of dynamic exercise therapy on radiological progression
and functional ability is needed.
相似文献
92.
胰岛ε细胞的研究进展 总被引:3,自引:0,他引:3
胰腺由外分泌组织和内分泌组织2个部分所组成,两者在机体能量平衡和营养代谢调节中发挥重要的作用.胰岛是胰腺组织中重要的内分泌功能单位,胰岛的发育和分化过程涉及一个复杂而精细的分子调控网络体系,其中包括许多转录因子的参与.经典的胰岛内分泌细胞包括α细胞、β细胞、δ细胞及PP细胞,分别产生胰升糖素、胰岛素、生长抑素及胰多肽(PP),各种胰岛细胞之间的相互调节在维持血糖稳态中具有重要的意义.表达ghrelin 的ε细胞是一种新近发现和命名的胰岛细胞类型.现着重对胰岛ε细胞的发现过程、形态学特点及生物学作用进行介绍. 相似文献
93.
Pascal H. E. Teeuwen Pim C. E. J. Sloots Ivo de Blaauw Rene Wijnen Jan Biert 《European journal of trauma and emergency surgery》2009,35(3):311-313
Abstract
We report a lethal case of fat embolism syndrome in a nine-year-old child after a direct blunt trauma leading to a pelvic
fracture. On the second day, signs of bowel perforation and septic shock led to an acute aggravation of the pulmonary symptoms,
cardiac arrest and death. Fat embolism is seldom thought to occur in pediatric trauma patients; however, this case illustrates
it can lead to disastrous sequela. Since there is no specific treatment for it, prevention by early fracture stabilization
is the only option. 相似文献
94.
Anne C. Kim Aimee C. Pastor Cornelius E.J. Sloots Matthew D. Neal Erin K. Tkach Nicolaas M.A. Bax Jennifer N. Chamberlain 《Journal of pediatric surgery》2010,45(6):1213-863
Purpose
Previous studies have reported decreased continence in patients undergoing transanal endorectal pull-through (TERP) for Hirschsprung's disease compared to the older transabdominal approach (TAA). To address this, we examined long-term stooling outcomes in a large, multicenter cohort of patients undergoing either TERP or TAA.Methods
Data were collected from 5 large pediatric institutions. Patient families were surveyed using a stooling score system (0-40, best to worst total score). Inclusion criteria included patients older than 3 years and those who had more than 6 months of recovery after pull-through. Those with total colonic aganglionosis were excluded. Statistical analysis included univariate and multivariate linear regression (significance, P < .05).Results
Two hundred eighty-one patients underwent TERP (192) or TAA (89). Interviews were completed in 149 (104 [52%] TERP vs 45 [52%] TAA). The TAA group had a significantly greater number of daily bowel movements for each respective postoperative year and experienced more early complications (3% vs 1% with >1 complication; P = .061) and late complications (19% vs 4% with >1 complication; P < .001). Although the TAA group had a higher mean enterocolitis score (3.3 ± 0.4 vs 1.8 ± 0.2; P < .001), this was not borne out by multivariate regression analysis (P = .276). Parental survey showed that there were no significant differences between procedures in mean total, continence, or stooling pattern scores.Conclusion
Transanal endorectal pull-through was associated with fewer complications and fewer episodes of enterocolitis. In contrast to prior studies, TERP patients did not have a higher rate of incontinence. These results support use of TERP as an excellent surgical approach for children with Hirschsprung's disease. 相似文献95.
96.
97.
PD Scheffer-Marinus TP Links WD Reitsma NM Drayer 《Acta paediatrica (Oslo, Norway : 1992)》1999,88(4):384-388
This study was conducted to analyse the effect of childhood-onset diabetes mellitus on adult height. The height at time of diagnosis of 35 children with insulin-dependent diabetes mellitus (IDDM) was compared with growth reference data. Predictions of the adult height were made at the time of diagnosis using the target height and the Tanner-Whitehouse II method. The adult height was compared with both the predicted values and the height of healthy adults. The height at time of diagnosis of the prepubertal children was increased compared with growth reference data, in contrast to pubertal children who had normal heights. Only the prepubertal boys were taller at time of diagnosis. The adult height of the prepubertal patients was taller than growth reference data. The mean adult height in all patients did not differ significantly from the predicted heights. In conclusion, the increased height at the start of IDDM in prepubertal children persists until adulthood. 相似文献
98.
E. Schmiedeke I. de Blaauw M. Lacher S. Grasshoff-Derr A. Garcia–Vazquez S. Giuliani P. Midrio P. Gamba BD. Iacobelli P. Bagolan G. Brisighelli E. Leva C. Cretolle S. Sarnacki P. Broens C. Sloots I. van Rooij N. Schwarzer D. Aminoff M. Haanen E. Jenetzky 《Pediatric surgery international》2015,31(8):741-745
99.
Alexander EJ. Powles David J. Martin Irving TP. Wells Christopher R. Goodwin 《Anaesthesia and Intensive Care Medicine》2018,19(4):202-205
Ultrasound is a form of non-ionizing radiation that uses high-frequency sound waves to image the body. It is a real-time investigation which allows assessment of moving structures and also facilitates measurement of velocity and directionality of blood flow within a vessel. It can be used for a variety of purposes in the intensive care setting, for example to aid central venous catheter and pleural drain insertion. When using this imaging modality it is vital to understand the relevant physical principles and how the images are created. This article will explain these principles, including the use of Doppler ultrasound and the interpretation of common artefacts. 相似文献
100.
TP Jürgens C Schaefer & A May 《Cephalalgia : an international journal of headache》2009,29(4):391-400
Cluster headache is a rare disorder in women, but has a serious impact on the affected woman's life, especially on family planning. Women with cluster headache who are pregnant need special support, including the expertise of an experienced headache centre, an experienced gynaecologist and possibly a teratology information centre. The patient should be seen through all stages of the pregnancy. A detailed briefing about the risks and safety of various treatment options is mandatory. In general, both the number of medications and the dosage should be kept as low as possible. Preferred treatments include oxygen, subcutaneous or intranasal sumatriptan for acute pain and verapamil and prednisone/prednisolone as preventatives. If there is a compelling reason to treat the patient with another preventative, gabapentin is the drug of choice. While breastfeeding, oxygen, sumatriptan and lidocaine for acute pain and prednisone/prednisolone, verapamil, and lithium as preventatives are the drugs of choice. As the individual pharmacokinetics differ substantially, adverse drug effects should be considered if unexplained symptoms occur in the newborn. 相似文献