“Risk management” is a verb

To optimally demonstrate the value of risk management, our actions must show the benefits. The American Society for Healthcare Risk Management (ASHRM) board needs to provide support through tools and resources. ASHRM members must show through their actions the value of risk management. And ASHRM members need to show the organization where actions and activities should be focused in the future. Actions show the value of enterprise risk management.     

Deconstructing adolescent same-sex attraction and sexual behavior in the twenty-first century: perspectives for the clinician

The adolescent with same-sex attraction in the twenty-first century straddles ambivalent cultural and religious attitudes regarding gay, lesbian, bisexual, or transgender (GLBT) issues; rapid technologic advances that provide easy access to information on sex and sex partners; and the clinician's sensitivity about GLBT issues and his or her awareness of how adolescents can use technology for sex-seeking behavior. It is necessary to deconstruct these factors into defined frameworks. Three checklists, the Clinician's Framework Guide Questions for the GLBT Adolescent, Clinician Reaction to GLBT Issues Checklist, and Global GLBT Checklist for Biopsychosocial Risk Factors, may aid the clinician in acquiring an appreciation of the global dynamics between the gay adolescent, the clinician, and the impact of current social realities.     

Interleukin-4 and interleukin-5 map to human chromosome 5 in a region encoding growth factors and receptors and are deleted in myeloid leukemias with a del(5q)

Interleukin-4 (IL-4) is a potent mediator of growth and differentiation of cells of several hematopoietic lineages. Interleukin-5 (IL-5) is a lineage-specific hematopoietic growth factor that stimulates the production of eosinophils and eosinophil colonies from normal human bone marrow cells. By using somatic cell hybrids and in situ chromosomal hybridization, we localized the IL-4 and IL-5 genes to human chromosome 5 at bands q23-31, a chromosomal region that is frequently deleted [del(5q)] in patients with myeloid disorders. By in situ hybridization, the IL-4 and IL-5 genes were found to be deleted in the 5q- chromosome of four patients with refractory anemia (RA) or therapy-related acute nonlymphocytic leukemia (t-ANLL), who had a del(5q). Thus a small segment of chromosome 5 contains IL-4, IL-5, IL- 3, and GM-CSF as well as other genes such as CD14 and EGR1. Our findings that each of these genes was deleted in the 5q- chromosome suggest that loss of function of one or more of these genes may play an important role in the pathogenesis of hematologic disorders associated with a del(5q).