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41.
S Siegler H J Hillstrom W Freedman G Moskowitz 《American journal of physical medicine》1985,64(3):130-149
The relationship between the force generated by an isometrically contracting muscle and the associated myoelectric signal has been the subject of extensive investigation in the past and conflicting results were reported regarding this relationship. The objective of the present study was to investigate some of the sources that may lead to such conflicting results. Two possible sources were examined. The first was the variability in the force-EMG relationship resulting from processing the EMG signal with different EMG signal processing techniques and the second was the variability in the force-EMG relation obtained from repeated muscle contractions. The results of the study indicate that slight variations in the force-EMG relationships can be attributed to the selection of different processing techniques. However, the variability in the force-EMG relation, obtained by using different EMG signal processors, was found to be significantly smaller than the variability in this relationship obtained from repeated muscle contractions. 相似文献
42.
J. Bertrand N. Siegler T. Murez G. Poinas B. Segui D. Ayuso P. Gres L. Wagner R. Thuret P. Costa S. Droupy 《World journal of urology》2014,32(1):233-237
Purpose
To compare postoperative complications in patients with or without preoperative immunonutrition before cystectomy.Methods
A prospective, multicenter, pilot, case–control study was conducted during 6 months. Patients with 7-day preoperative immunonutrition were prospectively included and compared with a retrospective, matched control group without immunonutrition. Early complication rates and the length of hospital stay were analyzed. The bilateral type I error was <0.05; the power was 90 %. Thirty patients in each group were required.Results
Thirty patients were included in each group, on a comparable basis. In the immunonutrition group, fewer postoperative complications (40 vs. 76.7 %; p = 0.008), less paralytic ileus at D7 (6.6 vs. 33.3 %; p = 0.02), fewer infections (23.3 vs. 60 %; p = 0.008), and in particular less pyelonephritis (16.7 vs. 46.7 %; p = 0.03) occurred. Clavien’s grades for complications were higher in the control group (p = 0.04). Mortality, pulmonary embolism, anastomotic fistulae, and wound dehiscence were similar between two groups. The length of stay was reduced by 3 days in the immunonutrition group.Conclusions
In this pilot case–control study, immunonutrition is associated with a decrease in postoperative complications, urinary tract infections, Clavien’s grade for complications, and paralytic ileus in patients undergoing cystectomy for bladder cancer. Prospective randomized placebo control studies are needed to confirm these promising results. 相似文献43.
Menzel T; Rahman Z; Calleja E; White K; Wilson EL; Wieder R; Gabrilove J 《Blood》1996,87(3):1056-1063
Chronic lymphocytic leukemia (CLL) is characterized by delayed senescence and slow accumulation of monoclonal, small lymphocytes. Basic fibroblast growth factor (bFGF) is a pleiotropic cytokine that plays a role in hematopoiesis and apoptosis. Elevated bFGF levels have been detected in urine from patients with a variety of neoplastic diseases including various leukemias; however, the cellular source of the bFGF has not been determined. In this study, the intracellular bFGF level in lymphocytes of 36 patients with B-CLL and 15 normal donors was determined using an enzyme-linked immunoassay. In cells derived from patients with high-risk disease, the median level of intracellular bFGF was 381.5 pg/2 x 10(5) cells, compared with a median of 90.5 pg/2 x 10(5) cells in patients with intermediate disease. In patients with low- risk disease, the median bFGF level was 4.9 pg/2 x 10(5) cells, and in normal controls, it was 6.0 pg/2 x 10(5) cells. The difference in the bFGF levels was significant for the comparison between low- and intermediate-risk (P = .00119), low- and high-risk (P < .0001), and intermediate- and high-risk disease (P = .0001). Immunofluorescent stains of peripheral blood mononuclear cells confirmed CLL lymphocytes as a cellular source of bFGF. To evaluate the potential contribution of elevated intracellular bFGF levels to the phenotype of CLL cells, leukemic cells were cultured in vitro with an apoptotic stimulus (fludarabine). CLL cells with high intracellular levels of bFGF appeared to be more resistant to fludarabine treatment. The addition of bFGF to fludarabine-treated CLL cells resulted in a delay of apoptosis and prolonged survival. These data suggest that bFGF may contribute to the resistance of CLL cells to an apoptotic stimulus. 相似文献
44.
B.H. Siegler S. Weiterer C. Lichtenstern D. Stumpp T. Brenner S. Hofer Prof. Dr. M.A. Weigand F. Uhle 《Der Anaesthesist》2014,63(8-9):678-690
Sepsis and related complications are a challenge for intensive care medicine. Despite many advances in antibiotic therapy sepsis remains one of the most common diseases of patients in intensive care units and is designated as the main cause of death in critically ill patients. Persisting sepsis leads to impaired immunity, resulting in immunosuppression. Unspecific predictive signs complicate an early diagnosis; however, an early initiation of adequate therapy is of crucial importance for the prognosis. Scoring systems can be applied for the initial evaluation but are controversially discussed concerning the monitoring of disease progression and therapy as well as outcome prediction. Biomarkers are considered as a complementary approach. 相似文献
45.
TESFALDET T. MICHAEL M.D. M.P.H. OWEN MOGABGAB M.D. ERIC FUH M.D. VISHAL G. PATEL M.D. ABDALLAH EL SABBAGH M.D. MOHAMMED E. ALOMAR M.D. BAVANA V. RANGAN B.D.S. M.P.H. SHUAIB M. ABDULLAH M.D. SUBHASH BANERJEE M.D. EMMANOUIL S. BRILAKIS M.D. Ph.D. 《Journal of interventional cardiology》2014,27(1):36-43
Objective
To assess the outcomes of the “hybrid” approach to chronic total occlusion (CTO) percutaneous coronary interventions (PCIs).Background
The “hybrid approach” to CTO PCI advocates appropriate and early change of crossing strategy to maximize success, safety, and efficiency.Methods
We prospectively recorded and analyzed detailed step‐by‐step procedural data in 73 consecutive CTO PCI cases performed by a single operator between July 2011 and August 2012.Results
Technical success was achieved in 66 of 73 cases (90.4%). Mean patient age was 65 ± 7 years, and 30% had prior coronary artery bypass surgery. Dual injection was used in 78%. The primary approach was retrograde in 9 cases (12.5%) and antegrade in 64 cases (87.5%), of whom 25 cases (39.1%) underwent retrograde attempt after failed antegrade approach. The initial crossing approach was successful in 40 cases (54.8%), but 32 cases (44%) required 3.6 ± 1.4 approach changes (range 2–7). Antegrade wire escalation, antegrade dissection/reentry, and retrograde crossing were utilized in 97.2%, 46.6%, and 46.6% of cases, respectively. Among successful cases, the final CTO crossing technique was antegrade wire escalation in 50.0%, antegrade dissection/reentry in 24.2%, and retrograde in 25.8%. The mean procedure time, fluoroscopy time, and air kerma radiation exposure until CTO crossing or stopping the procedure were 66 ± 55 minutes, 25 ± 23 minutes, and 2.3 ± 1.9 Gray, respectively. Three patients (4.1%) had a major complication.Conclusion
In the “hybrid approach” to CTO PCI, changes in crossing strategy were needed in approximately half the cases, resulting in high success and low complication rates. (J Interven Cardiol 2014;27:36–43)46.
Jean Salem Ali Shamseddine Mohamad Khalife Ghina El Nounou Abdallah Abou EL Naaj Deborah Mukherji Ali Haydar Walid Faraj 《International journal of surgery case reports》2014,5(12):1162-1163
BACKGROUND
Malignant fibrous histiocytoma, a subtype of primary lung sarcoma is a very rare disease. It usually presents as a lung nodules and the final diagnosis is made by immunohistochemical studies.METHODS
A 45-year-old patient presented with progressive dyspnea, dry cough and right shoulder pain. Chest X-ray revealed complete opacification of the right hemithorax. Chest computed tomography confirmed the presence of a heterogeneous lesion occupying the whole right hemithorax causing a mass effect on the trachea. Ultrasound guided biopsy was done and final pathology was suggestive of malignant fibrous histiocytoma.CONCLUSION
Progressive dyspnea in young otherwise healthy patients should be investigated early on. In our case the presence of right shoulder pain indicates advance disease illustrated by the singular imaging findings. 相似文献47.
ALAIN PATAT MICKEL CERCLE SUZANNE TROCHERIE GUYLAINE PEYTAVIN CHRISTOPHE POTIN HERV ALLAIN JEAN-MARC GANDON 《Human psychopharmacology》1996,11(4):321-335
Mefenorex is an indirect sympathomimetic amine which acts as an anorectic drug and is used in combination with low diet to treat excess weight. The central nervous system (CNS) effects of mefenorex were assessed in a randomized, double-blind, three-way cross-over, placebo-controlled study involving nine healthy young male volunteers. They received either a single oral dose of mefenorex 80 mg (twice the recommended dose) or d-amphetamine sulfate 18 mg or a placebo at 1-week intervals. CNS pharmacodynamic measurements consisted of subjective evaluation (visual analogue scales and the Addiction Research Centre inventory (ARCI)), EEG, psychomotor performance and attention (tracking, simple and choice reaction times, tapping, continuous performance task, DSST, body sway) and memory (working memory and recall of a word list). d-Amphetamine produced a typical psychostimulant EEG profile (significant decrease in slow delta waves and increase in fast beta activities), significantly increased amphetamine, benzedrine and morphine–benzedrine scores of ARCI and significantly decreased body sway compared to placebo and mefenorex. A trend in favour of a stimulant effect occurred for all other parameters (particularly speed of reaction) and no changes of memory were noticed. In contrast, mefenorex did not produce an amphetamine-like EEG profile, neither significantly changed ARCI scores nor significantly modified psychomotor and memory performance compared to the placebo, although it induced a decrease in body sway. In conclusion, the present results indicate that a single oral dose of mefenorex, at twice the recommended daily dose, does not possess amphetamine-like subjective and EEG stimulant effects or sensations of well-being, often encountered with drugs of abuse liability potential, in a healthy young population. 相似文献
48.
Dana C. Hughes Gerda G. Fillenbaum Max A. Woodbury Ilene C. Siegler 《International journal of geriatric psychiatry》1996,11(5):439-455
The Mini-Mental State Examination (MMSE), a brief, widely used measure of cognitive status, was designed to assess functioning in five areas (orientation, registration, attention and calculation, recall and language). Using a grade of membership analysis, which does not rely on a multivariate normal distribution or assume an underlying continuum for dichotomously scored variables, we examined data from a sample of 1317 community residents 18 years of age and older who made two or more errors on the MMSE. Our findings suggest that for these primarily cognitively intact persons, the items of the MMSE varied in level of difficulty; multiple distinct areas of cognitive functioning were not identified. The results of confirmatory testing using clinic populations with cognitive deficit are given in the accompanying article. 相似文献
49.