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Efficacy of ixekizumab compared to etanercept and placebo in patients with moderate‐to‐severe plaque psoriasis and non‐pustular palmoplantar involvement: results from three phase 3 trials (UNCOVER‐1, UNCOVER‐2 and UNCOVER‐3)
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Shunji Suzuki Fukiko Yamada Masako Eto 《The journal of maternal-fetal & neonatal medicine》2018,31(11):1524-1526
Objective: We examined the relation between intimate partner violence (IVP) and maternal mental status such as depression and anxiety.Methods: Between April 2016 and October 2016, we asked all Japanese women during the first trimester of pregnancy to answer the three self-administered questionnaires to screen IVP and depressive and anxiety symptoms.Results: There were 19 women who had a high score in the modified Violence Against Women Screen (VAWS) (4.1%, IPV group) and 408 women who had a score 0 (86.8%, control group). Overall, the rate of the women with depressive, anxiety, and depressive plus anxiety symptoms were 21.3, 31.5, and 16.0%, respectively. The rate of depressive and/or anxiety symptoms in the IPV group were significantly higher than those in the control group (Odds ratio?=?5.02 and 7.40, p?.01 by X2 test).Conclusions: The significant adverse effect of IPV on maternal mental status seemed to be observed in Japanese women during the first trimester of pregnancy. 相似文献
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Analysis of factors predicting the response to tolvaptan in patients with liver cirrhosis and hepatic edema
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Masanori Atsukawa Keizo Kato Hiroshi Abe Noritomo Shimada Toru Asano Tadashi Ikegami Mai Koeda Tomomi Okubo Taeang Arai Ai Nakagawa‐Iwashita Yuji Yoshida Korenobu Hayama Norio Itokawa Chisa Kondo Yoshimichi Chuganji Yasushi Matsuzaki Katsuhiko Iwakiri 《Journal of gastroenterology and hepatology》2018,33(6):1256-1263
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Kazuhiro Yoshimura Shunji Nakano Daisuke Tsuruta Chika Ohata Takashi Hashimoto 《The Journal of dermatology》2013,40(6):471-474
Plasma cell cheilitis is a chronic inflammatory disease that presents with erythema, erosions, ulcers and occasional nodules within the mucosa, including the lips. It is histopathologically characterized by dense plasma cell infiltration in the lamina propria of the mucous membranes. Several treatments for plasma cell cheilitis have been reported, including topical steroids, topical antibiotics or topical tacrolimus. However, 308‐nm monochromatic excimer light (MEL) has never been reported as a treatment option, while it was reported to be very effective in treating erosive oral lichen planus. We report a 62‐year‐old man who had chronic plasma cell cheilitis on the lower lip, which was refractory to topical and systemic corticosteroid. The lesion and severe pain were significantly improved by the treatment with nine sessions of 308‐nm MEL twice per week with a total dose of 1120 mJ/cm2. However, the lesion gradually worsened after treatment frequency was reduced to once per month. Subsequent tacrolimus 0.03% ointment cleared the lesion completely in a month and no recurrence was observed a year later. Refractory plasma cell cheilitis and concomitant severe pain quickly responded to 308‐nm MEL when administrated twice per week. Because the long interval between each MEL treatment seemed ineffective to improve the lesion, appropriate frequency and adequate total dose of MEL treatment may be necessary for a successful treatment. 相似文献
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