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排序方式: 共有962条查询结果,搜索用时 46 毫秒
21.
Shinzaki Shinichiro Matsuoka Katsuyoshi Tanaka Hiroki Takeshima Fuminao Kato Shingo Torisu Takehiro Ohta Yuki Watanabe Kenji Nakamura Shiro Yoshimura Naoki Kobayashi Taku Shiotani Akiko Hirai Fumihito Hiraoka Sakiko Watanabe Mamoru Matsuura Minoru Nishimoto Shohei Mizuno Shinta Iijima Hideki Takehara Tetsuo Naka Tetsuji Kanai Takanori Matsumoto Takayuki 《Journal of gastroenterology》2021,56(6):560-569
Journal of Gastroenterology - This multicenter prospective study (UMIN000019958) aimed to evaluate the usefulness of serum leucin-rich alpha-2 glycoprotein (LRG) levels in monitoring disease... 相似文献
22.
A giant retention cyst of the pancreas (cystic dilatation of dorsal pancreatic duct) associated with pancreas divisum 总被引:1,自引:0,他引:1
Morise Z Yamafuji K Tsuji T Asami A Takeshima K Hayashi N Baba H Yoshida F Abe Y Tokura Y 《Journal of gastroenterology》2002,37(12):1079-1082
We describe a rare case of pancreas divisum associated with a giant retention cyst (cystic dilatation of the dorsal pancreatic
duct), presumably formed following obstruction of the minor papilla. The patient was treated by pancreatico(cysto)jejunostomy.
A 50-year-old man was admitted with complaints of increasing upper abdominal distension and body weight loss. There was no
previous history of pancreatitis, gallstones, drinking, or abdominal injury. An elastic-hard tumor-like resistance was palpable
in the upper abdomen. Computed tomography and ultrasound (US) examinations revealed a giant cystic lesion expanding from the
pancreas head to the tail. Endoscopic retrograde cholangiopancreatography findings showed a looping pancreatic duct which
drained only the head and uncinate process of the pancreas to the main papilla. A US-guided puncture to the cystic lesion
revealed that the lesion continued to the main pancreatic duct in the tail of pancreas. The lesion was connected to a small
cystic lesion, which was located inside the minor papilla, and ended there. The amylase level in liquid aspirated from the
cyst was 37 869 IU/l, and the result of cytological examination of the liquid showed class II. A pancreatico(cysto)jejunostomy
was performed, with the diagnosis being pancreas divisum associated with a retention cyst following obstruction of the minor
papilla. The histological findings of a specimen from the cyst wall revealed that the wall was a pancreatic duct covered with
mildly inflammatory duct epithelium; there was no evidence of neoplasm. The patient is currently well, and a CT examination
2 years after the operation showed disappearance of the cyst and normal appearance of the whole pancreas.
Received: April 24, 2001 / Accepted: September 14, 2001 相似文献
23.
Fujitaka K Isobe T Oguri T Yamasaki M Miyazaki M Kohno N Takeshima Y Inai K 《Respiration; international review of thoracic diseases》2002,69(3):277-279
We present a case of a 39-year-old woman with sporadic tuberous sclerosis (TSC), whose chest radiograph demonstrated bilateral diffuse nodular shadowing. A transbronchial lung biopsy specimen revealed the possibility of multiple atypical adenomatous hyperplasia (AAH), which had not been reported in TSC. Thoracoscopic lung biopsy was, therefore, performed. The specimens revealed the characteristic histological and immunohistochemical features of micronodular pneumocyte hyperplasia, which has been reported as an extremely rare pulmonary manifestation of TSC. In addition, no evidence of AAH or any other pulmonary involvements of TSC including lymphangioleiomyomatosis were detected in biopsy specimens obtained at thoracoscopy. 相似文献
24.
Emma Tabe Eko Niba Hisahide Nishio Yogik Onky Silvana Wijaya Poh San Lai Takenori Tozawa Tomohiro Chiyonobu Misaki Yamadera Kentaro Okamoto Hiroyuki Awano Yasuhiro Takeshima Toshio Saito Masakazu Shinohara 《Brain & development》2021,43(2):294-302
BackgroundSpinal muscular atrophy (SMA) is a neuromuscular disease caused by homozygous deletion of SMN1 exons 7 and 8. However, exon 8 is retained in some cases, where SMN2 exon 7 recombines with SMN1 exon 8, forming a hybrid SMN gene. It remains unknown how the hybrid SMN gene contribute to the SMA phenotype.MethodWe analyzed 515 patients with clinical suspicion for SMA. SMN1 exons 7 and 8 deletion was detected by PCR followed by enzyme digestion. Hybrid SMN genes were further analyzed by nucleotide sequencing. SMN2 copy number was determined by real-time PCR.ResultsSMN1 exon 7 was deleted in 228 out of 515 patients, and SMN1 exon 8 was also deleted in 204 out of the 228 patients. The remaining 24 patients were judged to carry a hybrid SMN gene. In the patients with SMN1 exon 7 deletion, the frequency of the severe phenotype was significantly lower in the patients with hybrid SMN gene than in the patients without hybrid SMN gene. However, as for the distribution of SMN2 exon 7 copy number among the clinical phenotypes, there was no significant difference between both groups of SMA patients with or without hybrid SMN gene.ConclusionHybrid SMN genes are not rare in Japanese SMA patients, and it appears to be associated with a less severe phenotype. The phenotype of patients with hybrid SMN gene was determined by the copy number of SMN2 exon 7, as similarly for the patients without hybrid SMN gene. 相似文献
25.
Yoshiyuki Okano Miki Okamoto Masahide Yazaki Ayano Inui Toshihiro Ohura Kei Murayama Yoriko Watanabe Daisuke Tokuhara Yasuhiro Takeshima 《Molecular genetics and metabolism》2021,132(1):63-70
Patients with citrin deficiency during the adaptation/compensation period exhibit diverse clinical features and have characteristic diet of high protein, high fat, and low carbohydrate. Japanese cuisine typically contains high carbohydrate but evaluation of diet of citrin-deficient patients in 2008 showed a low energy intake and a protein:fat:carbohydrate (PFC) ratio of 19:44:37, which indicates low carbohydrate consumption rate. These findings prompted the need for diet intervention to prevent the adult onset of type II citrullinemia (CTLN2). Since the publication of the report about 10 years ago, patients are generally advised to eat what they wish under active dietary consultation and intervention. In this study, citrin-deficient patients and control subjects living in the same household provided answers to a questionnaire, filled-up a maximum 6-day food diary, and supplied physical data and information on medications if any. To study the effects of the current diet, the survey collected data from 62 patients and 45 controls comparing daily intakes of energy, protein, fat, and carbohydrate. Food analysis showed that patient's energy intake was 115% compared to the Japanese standard. The confidence interval of the PFC ratio of patients was 20–22:47–51:28–32, indicating higher protein, higher fat and lower carbohydrate relative to previous reports. The mean PFC ratio of female patients (22:53:25) was significantly different from that of male patients (20:46:34), which may explain the lower frequency of CTLN2 in females. Comparison of the present data to those published 10 years ago, energy, protein, and fat intakes were significantly higher but the amount of carbohydrate consumption remained the same. Regardless of age, most patients (except for adolescents) consumed 100–200 g/day of carbohydrates, which met the estimated average requirement of 100 g/day for healthy individuals. Finally, patients were generally not overweight and some CTLN2 patients were underweight although their energy intake was higher compared with the control subjects. We speculate that high-energy of a low carbohydrate diet under dietary intervention may help citrin-deficient patients attain normal growth and prevent the onset of CTLN2. 相似文献
26.
27.
Takamura Yoshiaki Motoyama Yasushi Takatani Tsunenori Takeshima Yasuhiro Matsuda Ryosuke Tamura Kentaro Yamada Shuichi Nishimura Fumihiko Nakagawa Ichiro Park Young-Su Nakase Hiroyuki 《Journal of clinical monitoring and computing》2021,35(5):1055-1062
Journal of Clinical Monitoring and Computing - Balloon test occlusion (BTO) is a useful examination for evaluating ischemic tolerance to internal carotid artery (ICA) occlusion. The aim of this... 相似文献
28.
Itsuko Kitamura Nobuo Takeshima Mizuho Tokudome Kunio Yamanouchi Yoshiharu Oshida Yuzo Sato 《Geriatrics & Gerontology International》2003,3(1):50-55
Background: Aging is associated with a declining glucose tolerance, which is primarily caused by peripheral insulin resistance, and with a decline in physical activity. The aim of this study was to assess the effect of aerobic and resistance exercise training on insulin action in the elderly.
Methods: Fourteen healthy male subjects (age: 65–73 years) were enrolled and divided into two exercise groups: resistance training (RT) or a combined aerobic and resistance training (CT). Subjects participated in each training program three times a week for 12 weeks. Before and after the training program, insulin action was determined using the euglycemic clamp technique at insulin infusion rates of 40 (low) or 400 (high) mU/m2 per min. Body composition was measured by dual-energy X-ray absorptiometry (DXA).
Results: Percent fat decreased significantly in both groups. Fat-free mass (FFM) tended to increase in the RT group ( P = 0.054), but not in the CT group. In the CT group, the glucose infusion rate (GIR) increased 16.6% ( P < 0.05) at the low insulin infusion rate and 21.7% ( P < 0.01) at the high rate. In the RT group, GIR tended to increase at the low insulin infusion rate, but was not statistically significant ( P = 0.052) and increased 9.9% ( P < 0.05) at the high rate. When calculated per FFM, the increased insulin action persisted in the CT group ( P < 0.01), but not in the RT group.
Conclusion: The combination of aerobic and resistance training is more effective for improving the decreased insulin action in the elderly than resistance training alone. 相似文献
Methods: Fourteen healthy male subjects (age: 65–73 years) were enrolled and divided into two exercise groups: resistance training (RT) or a combined aerobic and resistance training (CT). Subjects participated in each training program three times a week for 12 weeks. Before and after the training program, insulin action was determined using the euglycemic clamp technique at insulin infusion rates of 40 (low) or 400 (high) mU/m
Results: Percent fat decreased significantly in both groups. Fat-free mass (FFM) tended to increase in the RT group ( P = 0.054), but not in the CT group. In the CT group, the glucose infusion rate (GIR) increased 16.6% ( P < 0.05) at the low insulin infusion rate and 21.7% ( P < 0.01) at the high rate. In the RT group, GIR tended to increase at the low insulin infusion rate, but was not statistically significant ( P = 0.052) and increased 9.9% ( P < 0.05) at the high rate. When calculated per FFM, the increased insulin action persisted in the CT group ( P < 0.01), but not in the RT group.
Conclusion: The combination of aerobic and resistance training is more effective for improving the decreased insulin action in the elderly than resistance training alone. 相似文献
29.
30.
Tetsu?AkimotoEmail author Hiromichi?Yoshizawa Yuko?Watanabe Akihiko?Numata Tomoyuki?Yamazaki Eri?Takeshima Kana?Iwazu Takanori?Komada Naoko?Otani Yoshiyuki?Morishita Chiharu?Ito Kazuhiro?Shiizaki Yasuhiro?Ando Shigeaki?Muto Makoto?Kuro-o Eiji?Kusano 《BMC nephrology》2012,13(1):155