全文获取类型
收费全文 | 2468篇 |
免费 | 107篇 |
国内免费 | 16篇 |
专业分类
耳鼻咽喉 | 45篇 |
儿科学 | 52篇 |
妇产科学 | 7篇 |
基础医学 | 257篇 |
口腔科学 | 107篇 |
临床医学 | 136篇 |
内科学 | 665篇 |
皮肤病学 | 41篇 |
神经病学 | 74篇 |
特种医学 | 89篇 |
外科学 | 531篇 |
综合类 | 8篇 |
预防医学 | 106篇 |
眼科学 | 26篇 |
药学 | 176篇 |
中国医学 | 4篇 |
肿瘤学 | 267篇 |
出版年
2023年 | 10篇 |
2022年 | 22篇 |
2021年 | 36篇 |
2020年 | 13篇 |
2019年 | 23篇 |
2018年 | 29篇 |
2017年 | 39篇 |
2016年 | 34篇 |
2015年 | 54篇 |
2014年 | 80篇 |
2013年 | 81篇 |
2012年 | 146篇 |
2011年 | 176篇 |
2010年 | 88篇 |
2009年 | 93篇 |
2008年 | 151篇 |
2007年 | 187篇 |
2006年 | 184篇 |
2005年 | 203篇 |
2004年 | 166篇 |
2003年 | 179篇 |
2002年 | 177篇 |
2001年 | 48篇 |
2000年 | 34篇 |
1999年 | 41篇 |
1998年 | 32篇 |
1997年 | 25篇 |
1996年 | 16篇 |
1995年 | 13篇 |
1994年 | 21篇 |
1993年 | 17篇 |
1992年 | 12篇 |
1991年 | 19篇 |
1990年 | 11篇 |
1989年 | 23篇 |
1988年 | 13篇 |
1987年 | 14篇 |
1986年 | 11篇 |
1985年 | 11篇 |
1984年 | 6篇 |
1983年 | 4篇 |
1982年 | 4篇 |
1981年 | 8篇 |
1980年 | 6篇 |
1979年 | 3篇 |
1978年 | 8篇 |
1977年 | 5篇 |
1974年 | 2篇 |
1971年 | 4篇 |
1968年 | 3篇 |
排序方式: 共有2591条查询结果,搜索用时 15 毫秒
71.
72.
73.
Naomi Sato Yasuhiro Nakamura Kentaro Takanami Yoshikiyo Ono Kei Omata Ryo Morimoto Fumitoshi Satoh Kazue Ise Shigeyuki Yamada Atsuko Kasajima Fumiyoshi Fujishima Mika Watanabe Yoichi Arai Hironobu Sasano 《Endocrine pathology》2014,25(4):410-415
Usually, benign tumors are not associated with an increased F-18 fluorodeoxyglucose (F-18 FDG) uptake on positron emission tomography (PET), although some exceptions have been reported in adrenal neoplasms. We present a rare case of adrenocortical oncocytoma associated with markedly increased FDG uptake, demonstrating a maximum standardized uptake value of 46.8. Histological examination demonstrated diffuse proliferation of tumor cells with eosinophilic and granular cytoplasm that were diffusely immunopositive for mitochondria and glucose transport protein 1, with focal and weak immunopositivity for 3β-hydroxysteroid dehydrogenase. Ultrastructural examination also revealed abundant mitochondria in the tumor cells. The tumor was diagnosed as adrenocortical oncocytoma and was considered benign according to Lin-Weiss-Bisceglia criteria. Diagnosis of adrenocortical oncocytoma can pose difficulties during both preoperative radiological and postoperative histopathological investigations. 相似文献
74.
Muraki S Akune T Oka H Ishimoto Y Nagata K Yoshida M Tokimura F Nakamura K Kawaguchi H Yoshimura N 《Arthritis and rheumatism》2012,64(5):1447-1456
75.
Kimura F Sato K Akiyama H Sao H Okamoto S Kobayashi N Hara M Kawa K Motoyoshi K;Japan Marrow Donor Program 《Bone marrow transplantation》2012,47(3):426-429
To study the effects of M-CSF administration on long-term outcomes of unrelated BMT, we retrospectively analyzed data from patients transplanted through the Japan Marrow Donor Program. We obtained data from 54 patients who received M-CSF just after BMT and 500 patients who did not receive M-CSF or G-CSF acted as controls. There were no significant differences between the two cohorts with respect to OS, acute GVHD or relapse. Although the incidence of chronic GVHD was comparable between the two groups, extensive chronic GVHD was observed significantly less often in the M-CSF cohort than in the control group. Multivariate analysis identified M-CSF as a significant factor for attenuating extensive chronic GVHD (relative risk: 0.73; 95% confidence interval: 0.55-0.94; P=0.012). We also found the same results in matched-pair analysis. Our observation suggests the potential for clinical use of M-CSF to dampen severe chronic GVHD. 相似文献
76.
77.
78.
Tamura S Ishida H Fujiki A Yoshihara T Kondo O Inoue M Kawa K Kawabata K Imamura T 《[Rinshō ketsueki] The Japanese journal of clinical hematology》2012,53(3):361-366
A 22-year-old man with chronic active Epstein-Barr virus infection underwent allogeneic bone marrow transplantation (allo-BMT) from an HLA two allele-mismatched unrelated donor. Ten months after allo-BMT, he developed protein-losing enteropathy following a respiratory syncytial virus infection. A diagnosis of a recurrent type of acute graft-versus-host disease (GVHD) was made based on the histopathological findings, such as the infiltration of T lymphocytes into the superficial epithelium and crypts, and apoptotic bodies in crypts. Although methylprednisolone (mPSL: 10 mg/kg) administration for two consecutive days improved gastrointestinal symptoms, acute pancreatitis and severe depression developed in association with corticosteroid treatment. Reduction of mPSL and administration of infliximab (5 mg/kg/dose, 3 times) resulted in rapid improvement of depression and pancreatitis without aggravating intestinal GVHD. Recent studies have demonstrated that tumor-necrosis-factor (TNF)-α is associated with not only GVHD but also depression and acute pancreatitis. In the present case, anti-TNF-α treatment enabled us to reduce corticosteroid dose without aggravating GVHD, which suggests that this approach might be effective for the treatment of depression and acute pancreatitis. 相似文献
79.
80.
Ebara S Song SN Mizuta H Ito Y Hasegawa K Kamata T Matsumura-Nishikawa T Ogawa T Soneda J Yoshizaki K 《International journal of hematology》2012,95(2):198-203
Dysregulated overproduction of interleukin-6 (IL-6) from activated B cells in affected lymph nodes has been implicated in
the pathogenesis of multicentric Castleman’s disease (MCD), a rare lymphoproliferative disorder accompanied by systemic manifestations.
We here report the case of a 32-year-old female presenting with MCD associated with a dermoid cyst in the pelvic cavity. The
co-occurrence of MCD and dermoid cyst has not been reported before. Immunohistochemical analysis of the tissue sections showed
IL-6 production in CD68-positive macrophage cells, which had infiltrated the dermoid cyst. Removal of the cyst resulted in
partial improvement in systemic symptoms accompanied by a decrease in serum IL-6, while complete improvement was obtained
by treatment with an anti-IL-6 receptor antibody following resection of the dermoid cyst. To the best of our knowledge, this
is the first study to provide evidence of IL-6 production by CD68+ cells in a dermoid cyst involved in MCD. 相似文献