全文获取类型
收费全文 | 205786篇 |
免费 | 19052篇 |
国内免费 | 14187篇 |
专业分类
耳鼻咽喉 | 1767篇 |
儿科学 | 2443篇 |
妇产科学 | 3327篇 |
基础医学 | 23505篇 |
口腔科学 | 3643篇 |
临床医学 | 26768篇 |
内科学 | 31670篇 |
皮肤病学 | 2322篇 |
神经病学 | 10567篇 |
特种医学 | 7338篇 |
外国民族医学 | 101篇 |
外科学 | 21136篇 |
综合类 | 34291篇 |
现状与发展 | 51篇 |
一般理论 | 16篇 |
预防医学 | 14250篇 |
眼科学 | 5613篇 |
药学 | 21406篇 |
183篇 | |
中国医学 | 11186篇 |
肿瘤学 | 17442篇 |
出版年
2024年 | 610篇 |
2023年 | 2886篇 |
2022年 | 7567篇 |
2021年 | 9583篇 |
2020年 | 7086篇 |
2019年 | 6477篇 |
2018年 | 6743篇 |
2017年 | 6282篇 |
2016年 | 5743篇 |
2015年 | 8691篇 |
2014年 | 10929篇 |
2013年 | 10296篇 |
2012年 | 14779篇 |
2011年 | 16120篇 |
2010年 | 10241篇 |
2009年 | 8357篇 |
2008年 | 10780篇 |
2007年 | 10903篇 |
2006年 | 10740篇 |
2005年 | 10289篇 |
2004年 | 7726篇 |
2003年 | 7829篇 |
2002年 | 6700篇 |
2001年 | 5839篇 |
2000年 | 5361篇 |
1999年 | 5398篇 |
1998年 | 3447篇 |
1997年 | 3317篇 |
1996年 | 2412篇 |
1995年 | 2258篇 |
1994年 | 1978篇 |
1993年 | 1186篇 |
1992年 | 1706篇 |
1991年 | 1485篇 |
1990年 | 1297篇 |
1989年 | 1115篇 |
1988年 | 984篇 |
1987年 | 885篇 |
1986年 | 705篇 |
1985年 | 597篇 |
1984年 | 341篇 |
1983年 | 232篇 |
1982年 | 144篇 |
1981年 | 144篇 |
1980年 | 95篇 |
1979年 | 137篇 |
1978年 | 67篇 |
1976年 | 59篇 |
1975年 | 56篇 |
1974年 | 71篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
41.
Xiujuan Tian Zhiying Chen Shaomin Shi Xianwen Wang Wanli Wang Ning Li Jing Wang 《Medicine》2015,94(37)
Oral cancer, predominantly oral squamous cell carcinoma (OSCC), is one of the most leading causes of cancers worldwide. Due to a low 5-year survival rate, highly effective methods for the early detection of OSCC are totally needed. MicroRNAs (miRNAs), as promising biomarkers, can bring insights into tumorigenesis of oral cancers. However, studies on the accuracy of miRNAs detection in OSCC have inconsistent conclusions, leading us to conduct this meta-analysis. The aim of this study was to systematically review the articles investigating the diagnostic value of miRNAs in OSCC.The PubMed, Embase, Chinese National Knowledge Infrastructure (CNKI), Web of Science were searched (updated to June 11th, 2015) to identify all articles evaluating the diagnostic yield of miRNAs for OSCC. The pooled sensitivity, specificity, and other diagnostic parameters were used to assess the performance of miRNAs assays on OSCC detection. Statistical analysis was conducted by employing the R software.The present meta-analysis comprised 23 studies from 10 articles, including 598 OSCC patients and 320 healthy individuals, available for analysis. The summary receiver operator characteristic (SROC) curve was plotted. Meanwhile, the pooled diagnostic parameters and the area under curve (AUC) were calculated based on all included studies. The pooled diagnostic parameters calculated from all 23 studies were as follows: pooled sensitivity of 0.759 (95% CI: 0.701–0.809), pooled specificity of 0.773 (95% CI: 0.713–0.823) and AUC of 0.832, which indicates a relatively high diagnostic accuracy of miRNAs in differentiating OSCC patients from healthy controls. Meanwhile, In addition, subgroup analyses were conducted to access the heterogeneity between studies, which is based on specimen (serum/plasma/blood/saliva/ tissue) and ethnicity (Asian/Caucasian).In summary, our meta-analysis suggests that miRNAs might be used in noninvasive screening tests for OSCC, which needs further large-scale studies to be validated. 相似文献
42.
43.
44.
45.
46.
47.
48.
49.
The serrated pathway (SP) can be viewed as two parallel, but partially overlapping, arrays of colorectal precursor lesions, and their respective endpoint carcinomas, that are distinct from those of the conventional adenoma–carcinoma sequence (APC‐pathway). In this review we focus at the outset on the clinical impact, pathological features, molecular genetics and biological behaviours of the various SP cancers. Then we summarize the clinicopathological features, classification and molecular profiles of the two main precursor lesions that anchor the respective pathways: (i) sessile serrated adenoma/polyp (SSA/P), also called sessile serrated lesion (SSL), and (ii) traditional serrated adenoma (TSA). Activating mutations of the RAS–RAF–MAPK pathway initiate and sustain the lesions of the SP, and CpG island methylation of the promoter regions of tumour suppressor and DNA repair genes play the major role in their neoplastic progression. The SP includes microsatellite stable (MSS) carcinomas that are among the most biologically aggressive colorectal carcinomas (CRC), and also accounts for the great preponderance of sporadic hypermutated, mismatch repair (MMR)‐deficient or microsatellite instable (MSI) CRC. The identification, removal and appropriate classification of at‐risk SP precursors and surveillance of individuals who harbour these lesions present a challenge and opportunity for CRC prevention and mortality reduction. 相似文献
50.
日间手术在国外已有上百年的发展历史,现已成为欧美国家重要手术模式。我国于20世纪初开始开展日间手术,但目前尚未普及,发展不平衡问题比较突出,存在认识不清、开展不规范、与医保支付对接不畅等问题。日间手术是一种使国家、医院和病人三方均受益的新型手术模式。近年来,国家相关管理部门积极引导,开展日间手术的医院明显增多,可以预见,我国日间手术即将进入快速发展的新阶段。因此,有条件的医院可以从简单、易操作的病种开始,落实临床路径,积累经验,再逐步稳妥展开。在保证质量的前提下,不断拓展日间手术范围,提高三、四级手术比例。同时,积极与医保支付政策对接,采取灵活的方式,获得医保的支持,更好地促进我国日间手术的快速发展。 相似文献