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71.
Neutrophilic urticarial dermatosis as a presenting feature of systemic juvenile idiopathic arthritis 下载免费PDF全文
Thomas Stringer BA Julia Gittler MD Shane Meehan MD Philip Kahn MD Vikash S. Oza MD 《Pediatric dermatology》2018,35(3):e170-e172
This report describes a case of chronic neutrophilic urticarial dermatosis as a presenting feature of systemic juvenile idiopathic arthritis. When encountered in children, neutrophilic urticarial dermatosis should raise suspicion of autoimmune or autoinflammatory disease. 相似文献
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Alcoholic cardiomyopathy (ACM) is a specific heart muscle disease found in individuals with a history of long-term heavy alcohol consumption. ACM is associated with a number of adverse histological, cellular, and structural changes within the myocardium. Several mechanisms are implicated in mediating the adverse effects of ethanol, including the generation of oxidative stress, apoptotic cell death, impaired mitochondrial bioenergetics/stress, derangements in fatty acid metabolism and transport, and accelerated protein catabolism. In this review, we discuss the evidence for such mechanisms and present the potential importance of drinking patterns, genetic susceptibility, nutritional factors, race, and sex. The purpose of this review is to provide a mechanistic paradigm for future research in the area of ACM. 相似文献
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JS Willey SA Lloyd GA Nelson TA Bateman 《Clinical reviews in bone and mineral metabolism》2011,9(1):54-62
Damage to normal, nontumor bone tissue following therapeutic irradiation increases the risk of fracture among cancer patients.
For example, women treated for various pelvic tumors have been shown to have a greater than 65% increased incidence of hip
fracture by 5 years postradiotherapy. Another practical situation in which exposure to ionizing radiation may negatively impact
skeletal integrity is during extended spaceflight missions. There is a limited understanding of how spaceflight-relevant doses
and types of radiation can influence astronaut bone health, particularly when combined with the significant effects of mechanical
unloading experienced in microgravity. Historically, negative effects on osteoblasts have been studied. Radiation exposure
has been shown to damage osteoblast precursors. Damage to local vasculature has been observed, ranging from decreased lumen
diameter to complete ablation within the irradiated volume, causing a state of hypoxia. These effects result in suppression
of bone formation and a general state of low bone turnover. More recently, however, we have demonstrated in preclinical mouse
models, a very rapid but transient increase in osteoclast activity after exposure to spaceflight and clinically relevant radiation
doses. Combined with long-term suppression of bone formation, this skeletal damage may cause long-term deficits. This review
will present a broad set of literature outlining our current set knowledge of both clinical therapy and space exploration
exposure to ionizing radiation. Additionally, we will discuss prevention of the initial osteoclast-mediated bone loss, the
need to promote normal bone turnover and long-term quality of bone tissue, and our hypothesized molecular mechanisms. 相似文献
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Rebecca C. Ramdhan Marios Loukas R. Shane Tubbs 《Clinical anatomy (New York, N.Y.)》2017,30(7):946-952
Hysterectomy is the most commonly performed gynecological procedure in the United States with three possible surgical approaches; vaginal, abdominal and laparoscopic. As with any surgical procedure, various anatomical complications can arise. These include injuries to anatomical structures such as the urinary bladder, ureter, intestines, rectum, anus, and a multitude of nervous structures. Other complications include sexual dysfunction, vaginal cuff dehiscence, and urinary incontinence. Using standard search engines, the anatomical complications of hysterectomies are reviewed. In conclusion, surgeons who perform hysterectomies or are involved with postoperative hysterectomy patients should be familiar with the possible complications of this common procedure and the steps that can be taken to help reduce the risk of those complications. Clinicians should also inform their patients of the potential complications as they can affect lifestyle and comfort. Clin. Anat. 30:946–952, 2017. © 2017 Wiley Periodicals, Inc. 相似文献
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Lindsey Cassidy Sujani Bandela Candace Wooten Coira Jennifer R. Shane Tubbs Marios Loukas 《Clinical anatomy (New York, N.Y.)》2014,27(6):815-820
Friedrich Trendelenburg's name is widely known today because it is associated with the Trendelenburg position. However, Trendelenburg made many other valuable contributions to the field of medicine, including a test, a gait, and a sign. A historical review of his life helps to elucidate the factors that contributed to his innovative approaches and techniques. Both Trendelenburg's mentors in his early years and the influences upon him throughout his professional career contributed to his development as a pioneer of surgery, anesthesia, and clinical diagnostics. Clin. Anat. 27:815–820, 2014. © 2014 Wiley Periodicals, Inc. 相似文献
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