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111.
Blood pressure independent effects of nitrendipine on cardiac structure in patients after renal transplantation 总被引:2,自引:2,他引:0
Rockstroh JK; Schobel HP; Vogt-Ladner G; Hauser I; Neumayer HH; Schmieder RE 《Nephrology, dialysis, transplantation》1997,12(7):1441-1447
Left ventricular hypertrophy is well established as a blood pressure
independent cardiovascular risk factor in patients on renal replacement
therapy. The effects of antihypertensive treatment on myocardial structure
and function in renal transplant recipients have been so far only rarely
investigated. In a double-blind, placebo-controlled study patients were
randomized to the calcium channel blocker nitrendipine or placebo if the
transplanted kidney had developed a stable phase. Normotensive patients
received nitrendipine 2 x 5 mg daily or placebo, hypertensive patients
received 2 x 10 mg up to 2 x 20 mg nitrendipine daily or placebo. To
achieve adequate blood pressure control, all patients with still elevated
blood pressure on study medication received antihypertensive drugs other
than calcium channels blockers. Ambulatory blood pressure recording and
2D-guided M-mode echocardiography were performed at baseline and upon
completion of the study. In addition, laboratory workup (including serum
creatinine and lipids) was done, and serum aldosterone, plasma renin
activity, plasma angiotensin II and blood glucose levels were measured in
all patients at baseline and after at least 12 months of therapy.
Ambulatory blood pressure was almost identical between both groups at study
baseline and follow-up. In renal transplant patients on nitrendipine,
posterior wall thickness (-0.10 +/- 1.77 mm) and septal wall thickness
(-0.83 +/- 2.23 mm) did not change significantly from baseline. In
contrast, posterior wall thickness (0.71 +/- 0.92 mm, P < 0.01) and
septal wall thickness (0.97 +/- 2.20 mm, P < 0.05) increased in patients
on placebo, which differed from the observed changes on nitrendipine
(ANOVA: P = 0.093 and P = 0.048, respectively). Relative wall thickness, a
parameter for concentric left ventricular hypertrophy, became numerically
smaller on nitrendipine therapy from 0.46 +/- 0.07 to 0.44 +/- 0.09 (-0.02
+/- 0.09, NS) but increased from 0.42 +/- 0.08 to 0.48 +/- 0.08 in the
placebo arm (+0.04 +/- 0.08, P < 0.02), which was also significant
between the two groups (ANOVA: P = 0.036). Endocrine parameters, lipids and
blood glucose were not different between the two groups. We conclude from
these data that the calcium channel blocker nitrendipine exerted beneficial
effects on cardiac structure in patients after renal transplantation
independent of blood pressure.
相似文献
112.
Anatomy of the perirenal area 总被引:2,自引:0,他引:2
The authors comment on the use of the renal bridging septa as a sign in distinguishing compartmentalization of the perinephric space. They also address new concepts regarding the spread of pancreatic effusions and provide information on other anatomic features of the perirenal area. 相似文献
113.
JK Wood 《Journal of clinical pathology》1991,44(10):879-880
114.
Connelly RJ; Hayden MS; Scholler JK; Tsu TT; Dupont B; Ledbetter JA; Kanner SB 《International immunology》1998,10(12):1863-1872
The combination of anti-CD2 mAb 9.6 and 9-1, specific for distinct
epitopes, induces proliferation of resting human T cells. The mitogenic
activity of this mAb mixture depends upon accessory cells and the 9-1 mAb
Fc domain. To further study the functional properties of these mAb, their
variable regions were cloned and expressed as monospecific single- chain Fv
(scFv) proteins fused to the human IgG1 Fc domain (scFvIg). A novel
bispecific scFvIg was constructed by cloning the two monospecific scFv
binding sites in tandem, with the 9.6 scFv placed N-terminal to the 9-1
scFvIg. Monospecific scFvIg binding to CD2 was comparable to that of the
corresponding parental mAb, while the bispecific scFvIg exhibited binding
activity similar to that of the 9-1 scFvIg. The combination of 9.6 scFvIg
and 9-1 mAb was mitogenic, whereas mixtures including the 9-1 scFvIg were
non-stimulatory, confirming the unique properties of the 9-1 IgG3 Fc.
Without the IgG3 tail, the bispecific 9.6/9-1 scFvIg was directly mitogenic
and was a more potent mitogen than the mAb mixture, but was accessory cell
dependent. Unlike the combination of mAb, the bispecific reagent did not
directly mobilize calcium in T cells. In comparison to the mAb mixture,
bispecific 9.6/9- 1 scFvIg-mediated stimulation of a mixed lymphocyte
reaction was significantly more resistant to inhibition of the CD28
co-stimulatory pathway by the inhibitor CTLA-4-Ig. These results show that
expression of the 9.6 and 9-1 binding sites together on a bispecific scFvIg
increased the mitogenic properties of the mAb and altered the degree of
accessory cell signals required for T cell activation.
相似文献
115.
Computed tomography of the normal thymus 总被引:7,自引:0,他引:7
116.
Bing-Fang Hwang Jouni JK Jaakkola How-Ran Guo 《Environmental health : a global access science source》2008,7(1):23
Background
Recent findings suggest that exposure to disinfection by-products may increase the risk of birth defects. Previous studies have focused mainly on birth defects in general or groups of defects. The objective of the present study was to assess the effect of water disinfection by-products on the risk of most common specific birth defects. 相似文献117.
JS Dugal V Jetley JK Sharma Charanjit Singh M Mehta JS Sabharwa Sunil Sofat P Bharadwaj 《Medical Journal Armed Forces India》2005,61(1):63-65
Background
Transcatheter closure of patent ductus arteriosus (PDA) with various devices has been evaluated worldwide and in selected cases can be performed successfully, thus avoiding the morbidity associated with surgical closure.Methods and results
A 2 year old female child presented with PDA and aortic angiography showed large PDA (tubular). This defect can be closed nonsurgically by coils and devices. The coil used are normally 0.038” having delivery system called Flipper, but this child had a large PDA and so was closed by thicker coil 0.052” using a coil-Bioptome-sheath system, which is the first reported case from the Armed Forces.Conclusions
We report the initial experience at our center of closure of PDA with a new coil-Bioptome-sheath system.Key Words: Patent Ductus Arteriosus (PDA), Children, Coil-Bioptome-Sheath system 相似文献118.
Shinpei Yoshii Okihiko Akashi Masahiro Kobayashi Atsuo Kojima Samuel JK Abraham Shunya Shindo Yusuke Tada Hiroji Higuchi 《General thoracic and cardiovascular surgery》2003,51(11):588-593
Objective: Continuous retrograde cerebral perfusion during aortic arch surgery is associated with cerebral edema. In this report, we describe the clinical use of a new type of intermittent retrograde cerebral perfusion.Subjects and Methods: Fourteen patients with a Stanford type A dissection were included in this study. With the usual method of retrograde cerebral perfusion, about 2,500 mL venous blood is drained from bicaval cannulae into a hard-shell reservoir, and oxygenated blood is perfused through the superior vena caval cannula. The flow rate is 300 mL/min. After about 15 min, retrograde perfusion is discontinued, and drainage from the bicaval cannulae is restarted. When a bloodless field is necessary, perfusion also is discontinued.Results: Two to seven cycles of intermittent retrograde cerebral perfusion were administered (average, 3.1±0.4, mean±SD). The total retrograde perfusion time was 36.0±1.9 min which was equivalent to 74.8% of the circulatory arrest time. No patient developed edema of the upper body. The time to wake-up was 3 to 14 h (average, 6.5±1.0h). No patient suffered any neurologic complications even though the time of circulatory arrest was greater than 60 min in four cases. Head magnetic resonance imaging or computed tomography was performed in 12 cases, and no evidence of hypoxic brain injury was detected.Conclusions: Our clinical experience using a moderate amount of intermittent retrograde cerebral perfusion is superior to continuous retrograde cerebral perfusion for protecting the brain during aortic arch surgery. 相似文献
119.
120.
T Coates GS Kirkland RB Dymock BF Murphy JK Brealey TH Mathew AP Disney 《American journal of kidney diseases》1998,32(3):384-391
Calcific uremic arteriolopathy (calciphylaxis) is an uncommon complication of chronic renal failure that is associated with high morbidity and mortality. We report 16 patients (13 female) who presented between 1985 and 1996. All patients developed painful livido reticularis that progressed to cutaneous necrosis and ulceration (11 cases on the proximal extremities and five cases on the distal extremities). Two patients with predominately distal leg disease survived; the cause of death in the other 14 patients was sepsis (six patients), withdrawal from dialysis (three), cardiac arrest (three), and gastrointestinal hemorrhage (two). Mesenteric ischemia from intestinal vascular calcification occurred in two cases. Clinical factors identified included the use of warfarin therapy in seven cases and significant weight loss (>10% body weight) in seven cases in the 6 months preceding the development of calcific uremic arteriolopathy. Skin pathology was studied in 12 cases, with all showing calcific panniculitis and small vessel calcification. Electron microscopic spectral analysis of the mineral content of the calcific lesions in the subcutaneous tissue showed only calcium and phosphorous. In two cases, substitution of low molecular weight heparin for warfarin therapy resulted in clinical improvement. Current theories of pathogenesis and treatment are reviewed. This study confirms the high morbidity and mortality of calcific uremic arteriolopathy producing ischemic tissue necrosis while drawing attention to significant weight loss and warfarin therapy as risk factors for the development of ischemic tissue necrosis. Hyperbaric oxygen therapy warrants further study. 相似文献