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51.
Sik‐Won Choi Jeong‐Tae Yeon Byung Jun Ryu Kwang‐Jin Kim Seong‐Hee Moon Hyuk Lee Myeung Su Lee Sam Youn Lee Jin‐Chul Heo Sang‐Joon Park Seong Hwan Kim 《Journal of bone and mineral research》2015,30(8):1494-1507
Drug repositioning is a rational approach for expanding the use of existing drugs or candidate drugs to treat additional disorders. Here we investigated the possibility of using the anticancer p21‐activated kinase 4 (PAK4)‐targeted inhibitor PF‐3758309 to treat osteoclast‐mediated disorders. PAK4 was highly expressed in bone marrow cells and was phosphorylated during their differentiation into osteoclasts, and osteoclast differentiation was significantly inhibited by the dominant negative form of PAK4 and by PF‐3758309. Specifically, PF‐3758309 significantly inhibited the fusion of preosteoclasts, the podosome formation, and the migration of preosteoclasts. PF‐3758309 also had in vivo antiresorptive activity in a lipopolysaccharide‐induced bone erosion model and in vitro antiosteoclastogenic activity in the differentiation of human bone marrow–derived cells and peripheral blood mononuclear cells into osteoclasts. These data demonstrate the relevance of PAK4 in osteoclast differentiation and the potential of PAK4 inhibitors for treating osteoclast‐related disorders. © 2015 American Society for Bone and Mineral Research © 2015 American Society for Bone and Mineral Research. 相似文献
52.
Man Seung Heo Hyun Seok Moon Hee Chan Kim Hyung Woo Park Young Hoon Lim Sun Ha Paek 《Journal of Korean Neurosurgical Society》2015,57(3):152-158
ObjectiveThe purpose of this study to develop new deep-brain stimulation system for long-term use in animals, in order to develop a variety of neural prostheses.MethodsOur system has two distinguished features, which are the fully implanted system having wearable wireless power transfer and ability to change the parameter of stimulus parameter. It is useful for obtaining a variety of data from a long-term experiment.ResultsTo validate our system, we performed pre-clinical test in Parkinson''s disease-rat models for 4 weeks. Through the in vivo test, we observed the possibility of not only long-term implantation and stability, but also free movement of animals. We confirmed that the electrical stimulation neither caused any side effect nor damaged the electrodes.ConclusionWe proved possibility of our system to conduct the long-term pre-clinical test in variety of parameter, which is available for development of neural prostheses. 相似文献
53.
Prevalence of the Brugada-type ECG recorded from higher intercostal spaces in healthy Korean males. 总被引:1,自引:0,他引:1
Seung Chul Shin Hyeon Min Ryu Jang Hoon Lee Byoung Jin Chang Jae Kook Shin Hyung Seop Kim Jung Ho Heo Dong Heon Yang Hun Sik Park Yongkeun Cho Shung Chull Chae Jae Eun Jun Wee Hyun Park 《Circulation journal》2005,69(9):1064-1067
BACKGROUND: Electrocardiograms (ECGs) recorded from the higher intercostal spaces (ICSs) are reported to be helpful for the diagnosis of Brugada syndrome (BS). However, the prevalence of Brugada-type ECG changes recorded from the higher ICSs is unknown in the healthy Korean population. METHODS AND RESULTS: A total of 225 healthy Korean male subjects with a mean age of 44+/-13 (20-69) years with no syncope or family history of sudden death were enrolled in the present study. ECGs were taken from 4th, 3rd, and 2nd ICSs and examined for Brugada-type ECG changes. There were none on the routine 12-lead ECGs, but 3 (1.3%) of the 225 subjects had a Brugada-type ECG recorded from the higher ICSs and 1 of them had a Brugada-type ECG recorded at both the 2nd and 3rd ICSs. The prevalence of the Brugada-type ECG was 1.3% at the 3rd ICS, 0.4% at the 2nd ICS. All were type 2. CONCLUSION: Some healthy Korean males with normal routine ECGs show Brugada-type 2 changes on ECGs recorded from higher ICSs. 相似文献
54.
Ki-Jong Kim Myoung Heo In-Ae Chun Hyun-Ju Jun PhDc Jin-Su Lee Hyuk Jegal Young-Sik Yang 《Journal of Physical Therapy Science》2015,27(1):309-312
[Purpose] The purpose of this study was to investigate the status of stroke in the
Republic of Korea and its relationship with QOL based on standardized data. [Subjects and
Methods] This study utilized raw data from the 2010 KCHS. In total, 229,229 individuals
participated in the 2010 survey. The final analysis identified 4,604 individuals who had
been diagnosed by a doctor with stroke. To identify the correlation between the
aftereffect-related characteristics of stroke patients and QOL, a multiple linear
regression analysis was performed. [Results] Participants experiencing aftereffects had a
statistically significantly lower QOL than participants who had not experienced
aftereffects. Regarding the types of aftereffects, participants experiencing palsy in the
arms and legs, facial palsy, communication disabilities, swallowing or eating
disabilities, and visual disabilities had a statistically significantly lower QOL than
participants without aftereffects. The QOL of participants with one, two, three, four, or
five aftereffects was statistically significantly less than that of participants without
aftereffects [Conclusion] Stroke directly influences QOL and the number of types of
aftereffects experienced by patients. Therefore, it is highly important that physical
therapists seek to end the occurrence of one or more types of aftereffects in stroke
patients.Key words: Stroke, Quality of life, Korean community healthy survey 相似文献
55.
Bomjin Lee Joongsook Lee Jeongok Yang Kwangjin Heo Hojin Hwang Boyoung Kim Dongwook Han 《Journal of Physical Therapy Science》2015,27(7):2159-2162
[Purpose] The purpose of this study was to observe the effects of stretching the upper
trapezius muscle on the asymmetric rate of bite force. [Subjects] Forty-seven female
university students who had all their original teeth, had no disorders in the
temporomandibular joints, and had never worn braces; participated in this study. [Methods]
An occlusometer was used to measure biting forces. Subsequently, stretching exercises of
the upper trapezius were performed. The subjects were divided into 3 groups at the start
of the testing: the asymmetric rate of the first group was less than 10%; the asymmetric
rate of the second group was between 10% and 20%; and the asymmetric rate of the third
group was more than 20%. The stretching exercises were done on the dominant side of the
upper trapezius. [Results] After the stretching exercises of the upper trapezius, the
results showed that for the first group, whose asymmetric rate of biting force was less
than 10%, there was a significant increase in asymmetric rate (from 5.1% to 10.3%). For
the second group, whose asymmetric rate of biting force was measured to be between 10% and
20%, the asymmetric rate decreased from 14.7% to 14.3%, but the change was not
statistically significant. For the third group, whose asymmetric rate of biting force was
more than 20%, there was a significant decrease in asymmetric rate (from 27.8% to 12.6%).
[Conclusion] We concluded that stretching exercises of the upper trapezius muscle had a
direct effect on the asymmetric rate of biting force.Key words: Asymmetric rate of biting force, Upper trapezius, Stretching exercise 相似文献
56.
Follicular variant of papillary thyroid carcinoma with B‐type RafV600E showing higher frequency of suspicious sonographic features and multifocality
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57.
Youn Moo Heo Jin Woong Yi Jung Bum Lee Dae Hee Lee Won Keun Park Sun Joong Kim 《Clinics in Orthopedic Surgery》2015,7(2):241-247
Background
Unstable simple elbow dislocation (USED) repair is challenged by the maintenance of joint reduction; hence, primary repair or reconstruction of disrupted ligaments is required to maintain the congruency and allow early motion of the elbow. We evaluated the effectiveness and the outcome of lateral collateral ligament (LCL) complex repair with additional medial collateral ligament (MCL) repair in cases of USED.Methods
We retrospectively reviewed 21 cases of diagnosed USED without fractures around the elbow that were treated with primary ligament repair. In all cases, anatomical repair of LCL complex with or without common extensor origin was performed using suture anchor and the bone tunnel method. Next, the instability and congruency of elbow for a full range of motion were evaluated under the image intensifier. MCL was repaired only if unstable or incongruent elbow was observed. Clinical outcomes were evaluated using the Mayo elbow performance score (MEPS) and radiographic outcomes on last follow-up images.Results
All cases achieved a stable elbow on radiographic and clinical results. LCL complex repair alone was sufficient to obtain the stable elbow in 17 of 21 cases. Four cases required additional MCL repair after restoration of the LCL complex. The overall mean MEPS was 91 (range, 70 to 100): excellent in 12 cases, good in 7 cases, and fair in 2 cases. All 17 cases with LCL complex repair only and 2 of 4 cases with additional MCL repair had excellent or good results by MEPS.Conclusions
USED requires surgical treatment to achieve a congruent and stable joint. If the repair of lateral stabilizer such as LCL complex acquires enough joint stability to maintain a full range of motion, it may not be necessary to repair the medial stabilizer in all cases of USED. 相似文献58.
[Purpose] The purpose of this study was to identify the effects of Kinesio Taping (KT) on
the swallowing function of stroke patients. [Subjects and Methods] Twenty-two stroke
patients were randomly assigned to two groups; an experimental group which received KT,
and a control group which received no taping intervention. Two-dimensional kinematic
analysis was used to determine the displacement of the hyoid bone and the angular
variation of the epiglottis using human anatomy-based coordinates. The functional
dysphagia scale (FDS) was determined by a videofluoroscopic study (VFSS). [Results] The
experimental group presented statistically significant improvements in kinematic changes
of the vertical excursion of the hyoid bone and epiglottal rotation. [Conclusion] Clinical
use of KT for dysphagia patients should be considered as a treatment approach. In future
research, more subjects and more diverse patterns should be studied to accumulate further
evidence.Key words: Kinesio Taping, Stroke, Dysphagia 相似文献
59.
Min-Yeong Heo Cheol-Yong Kim Chan-Woo Nam 《Journal of Physical Therapy Science》2015,27(11):3393-3395
[Purpose] The purpose of this study was to investigate the impact on the shoulder joints
of performing inelastic taping and bed physical therapy for acute stroke. [Subjects and
Methods] The intervention was conducted for eight weeks with an experimental group of 18
stroke patients who received bed physical therapy and inelastic taping and a control group
of 18 stroke patients who received only bed physical therapy. [Results] After the
intervention, the subluxation degree of the experimental group, which received bed
physical therapy and inelastic taping, was found to be significantly different from that
of the control group, which received only bed physical therapy. [Conclusion] In
conclusion, the application of inelastic taping for acute stroke patients was confirmed to
be effective at reducing shoulder subluxation and pain, and was confirmed to be a good
physical therapy intervention, based on its efficacy.Key words: Inelastic taping, Shoulder subluxation, Stroke 相似文献
60.
Background: Exacerbation of COPD is a major risk factor for bad prognosis of COPD. A few plasma proteins have been discovered to associate with hospital admission due to exacerbation up to date. We tried to find new plasma biomarkers to predict the exacerbation of COPD. Methods: We examined the plasma of normal control (n = 8) and COPD stable (n = 8) and exacerbation (n = 8) using 2-Dimentional Electrophoresis. The differentially expressed protein spots were identified by MALDI-TOF. ELISA were performed for quantitative measurement of RARα in plasma from normal control (n = 37) and COPD (n = 35). Results: 17 proteins were differentially expressed in plasma between stable and exacerbation state in the subjects with COPD. Identification using MALDI-TOF showed that retinoic acid receptor alpha, ninein, isoform CRA_a, alpha-1 antitrypsin, fibrinogen gamma, tyrosyl-DNA phosphodiesterase 2, and T cell receptor delta chain were increased in exacerbation of COPD, while fibrin beta, Crystal Structure Of An Autoimmune Complex Between A Human Igm RF* And Igg1 Fc, transferrin, serpin peptidase inhibitor member 6, complement factor B preproprotein, Chain B, Crig Bound To C3c, and WD repeat-containing protein 1 isoform 1 were decreased. Quantitative measurement showed that RARα plasma levels significantly increased in exacerbation state compared to stable state of COPD (n = 14). In the plasma of stable state, the COPD subjects (n = 14) having more than 0.4 time/yr of admission had very high levels of RAR alpha protein and those (n = 11) having less than 0.4 times/yr of admission had the intermediate levels compared to those having no exacerbation (n = 10). ROC analysis of RAR alpha levels to frequency of admission showed an area under the curve of 0.844. A cut-off of 0.154 ng/ml of RAR alpha predicted hospital admission with a sensitivity of 71.4% and a specificity of 92.8%. Conclusion: The proteomic analysis of plasma indicates that alteration of several proteins may be associated with admission of COPD. Among them, plasma RAR alpha level may predict hospital admission with a sensitivity of 71.4% and a specificity of 92.8%. 相似文献