Polycystic ovaries: MR imaging

To determine the characteristic appearance of polycystic ovaries on magnetic resonance (MR) images, seven women with polycystic ovarian disease (PCOD) underwent MR examination of the pelvis. These MR images were compared with sonograms. Histologic material was available in two patients. Six of the seven women had characteristic, small peripheral cysts, best seen on T2-weighted MR images; these cysts were seen sonographically in only one case. The centers of nine of 14 ovaries were of low intensity with all MR pulse sequences; this low intensity corresponded with low echogenicity in six cases. Histologically, these areas correlated with hypertrophic cellular stroma. Coexisting central teratomas were seen in three ovaries. The ability of MR to display the findings of PCOD better than ultrasound and its ability to demonstrate coexisting pathologic conditions are valuable in imaging the female pelvis.     

衍生化毛细管气相色谱法测定大鼠血浆中β—苯基乳酸

衍生化毛细管气相色谱法测定大鼠血浆中β—苯基乳酸莫谷强，张晓敏，程务本，李端，杨香媛（上海医科大学药学院仪器分析中心实验室２０００３２）β－苯基乳酸化学名为α－羟基β－苯基丙酸，由上海医科大学有机化学教研室董纪昌等合成（１），动物实验由上海医科大学药...     

Roughness and thrombogenicity of the outer surfaces of intravascular catheters

Thirty-seven types of catheters made from plastics including silicone rubber, polyvinylchloride, polyethylene, and polyurethane were tested for thrombogenesis in the cephalic vein of sheep. The range in the mass of thrombus on the catheters at autopsy 9 days after insertion was 20-fold. There was considerable variation when catheters made from the same types of plastic were compared, but polyethylene catheters tended to be more thrombogenic than other types. Scanning electron microscopy (SEM) revealed a variety of surfaces ranging from very smooth to very rough. Roughness was frequently associated with the presence of radioopaque particles which in several catheters were concentrated into radio-opaque tracer strips. Within types of plastics, catheters with rougher surfaces were usually more thrombogenic than those with smooth surfaces.     

Spine: device to facilitate surface coil MR imaging

A device was constructed to allow rapid adjustment of the position of a surface coil in magnetic resonance (MR) imaging of the spine. The device consists of two sheets of acrylic plastic and a movable sled. The surface coil is placed on the sled and can be precisely moved superiorly or inferiorly with a cord attached to the sled. The device can save approximately 30 minutes during MR imaging of the entire spine and increases patient comfort and cooperation.     

RP-HPLC法测定家兔血浆中甲苯喹哌浓度和药代动力学参数

本文建立了以紫外230nm波长检测的反相高效液相色谱法(RP-HPLC)测定家兔血浆中甲苯喹派浓度。填料使用LiChrosorb RP-C18,流动相为甲醇—水—三乙胺—磷酸(63:37:1:0.8 v/v),血样(或尿样)经碱化后用乙醚提取,再以0.2 mol/L硫酸回提,进样。方法回收率为99.84±3.10(SD)%;天内、天间精密度平均CV为4.12%及3.95%(n=5);最低检测限3ng.经提取的标准线性浓度在25～2000 ng/ml范围内,Y=0.002865X-0.01346,r=0.9999,内源性物质及可能的合并用药不干扰色谱测定。文内用质谱法鉴定血样中甲苯喹哌色谱峰纯度,并由尿样分析对其主要代谢物予以初步验证。本法可应用于药代动力学参数测定。家兔按8mg/kg静注后,药—时曲线符合二室模型T_(1/2)=4.8008±1.1522(SD)h。     

Avascular necrosis of the vertebral body: MR imaging

Five patients with plain radiographic evidence of a compressed vertebra containing an intravertebral vacuum cleft indicative of avascular necrosis underwent magnetic resonance (MR) imaging. In these patients, the T2-weighted images revealed a distinct appearance consisting of marked and discrete hyperintensity at the location of the intravertebral cleft. T1-weighted images were hypointense in this region. Recognition of this pattern is important in the MR imaging evaluation of compression fractures of the vertebral body so that confusion with malignancy or infection may be avoided, thereby obviating additional diagnostic studies.