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101.
102.
Hisayuki Hiraiwa Minoru Hamazaki Satoru Tsuruta Hiroyoshi Hattori Jun-Ichi Mimaya Shirou Hasegawa Sumio Kohno Katsuhiko Aoki 《Pediatrics international》1998,40(6):604-607
Infantile hemangioendothelioma of the thymus is a rare disease. We describe a patient who developed a large anterior mediastinal mass, severe thrombocytopenia and massive pleural effusion at 1 month of age. Glucocorticosteroid and irradiation therapy had no effect on either the tumor size or clinical symptoms and the tumor was resected subtotally. Three months after the subtotal resection, the remaining tumor had almost disappeared and the symptoms had resolved. The patient has now been well for 1 year after surgery without evidence of recurrence. The tumor tissue was characterized by prominent vascular endothelial proliferation intermixed with a normal thymic structure, producing a picture consistent with that of an infantile hemangioendothelioma in the thymus, lmmunohistochemically, the tumor cells showed positive staining for vimentin, factor VIII and CD34. The DNA stemline and proliferative activity were examined by flow cytometry, which revealed a diploid stemline with a low growth fraction. DNA content and cell cycle analyses of the tumor tissue may be useful for predicting the biological behavior of the tumor. 相似文献
103.
Macroscopic features at the deepest site of tumor penetration predicting liver metastases of colorectal cancer 总被引:2,自引:0,他引:2
Inomata M; Ochiai A; Sugihara K; Moriya Y; Yamaguchi N; Adachi Y; Kitano S; Hirohashi S 《Japanese journal of clinical oncology》1998,28(2):123-128
Liver metastasis is the gravest prognostic factor in colorectal cancer. To
identify a reliable indicator for liver metastasis, we evaluated
macroscopic features and seven established histopathological findings at
the cut section containing the deepest penetration using univariate and
multivariate analyses in 417 colorectal cancers. Macroscopic features were
divided into two types, streak type and non-streak type, according to the
presence or absence of white streak(s) at the advancing margin of tumor
invasion. Streak type was observed in 109 patients (26%). The frequency of
liver metastasis in streak type tumors (56%) was significantly higher than
that in non-streak type tumors (13%) (p < 0.001). The white streak
corresponded histologically with cancer cells showing focal
dedifferentiation with marked stromal and perivascular fibrosis extending
towards the serosa or adventitia. In 343 curatively treated patients,
univariate analysis showed that recurrent liver metastasis was
significantly associated with macroscopic features, venous invasion, focal
dedifferentiation and lymph node metastasis. Multivariate analysis
disclosed that macroscopic features and lymph node metastasis were
independent indicators of liver metastasis. These macroscopic features,
corresponding histologically to stromal behavior against invading cancer
cells, are a simple and useful indicator of liver metastasis of colorectal
cancer.
相似文献
104.
Takeshi Hanagiri Ichiro Yoshino Mitsuhiro Takenoyama Tomoko So Hiroshi Fujie Satoru Imabayashi Ryozo Eifuku Takashi Yoshimatsu Toshihiro Osaki Ryoichi Nakanishi Yuji Ichiyoshi Akira Nagashima Kikuo Nomoto Kosei Yasumoto 《Cancer science》1998,89(2):192-198
Lung cancer-specific cytotoxic T lymphocytes (CTL) were induced by repeated stimulations of regional lymph node lymphocytes (RLNL) in lung cancer patients with either autologous or HLA-A-locus-matched tumor cells. To investigate the effect of interleukin-12 (IL-12), IL-12 was added during the stimulation of RLNL from HLA A24 / adenocarcinoma patients with either autologous tumor cells or HLA A24-positive adenocarcinoma cells (PC-9) in combination with, or instead of interleukin-2 (IL-2), and then the cytotoxic activity, cytokine production and populations of the lymphocyte subsets were examined. The addition of IL-12, or the substitution of IL-2 by IL-12 was found to enhance the cytotoxic activity and the cytokine production (IFN-γ, GM-CSF) of the CTL as compared with IL-2 alone. The cytotoxic activity and cytokine production were both partially inhibited by anti-MHC-class I monoclonal antibody. The CTL thus induced by IL-12 had a higher proportion of CD3+ /CD56+ cells than the CTL induced with IL-2 alone. The positively selected CD8+ /CD56– lymphocytes showed PC-9-specific cytotoxic activity, because the population did not show any cytotoxicity to K562 or A549 (HLA-A26/A30). However, the CD3+ /CD56+ lymphocytes were cytotoxic to both PC-9 and K562. In conclusion, IL-12 is considered to be a useful cytokine for both the induction of lung-cancer specific CTL and the augmentation of non-MHC-restricted cytotoxicity against tumor cells, and may be applicable for adoptive immunotherapy using CTL. 相似文献
105.
Electrogastrography (EGG) is the cutaneous recording of gastric myoelectrical activity, and the dominant frequency reflects the rhythm of the gastric slow wave. Ambulatory EGG is contaminated with a large amount of motion artifacts, and it is unclear how much of the signals comprising the dominant frequency originates from non-gastric sources. The aim of the present study was to evaluate the pattern of gastric and non-gastric signals in the dominant frequency histogram (DFH) obtained from long-term ambulatory EGG recordings. Ten normal controls and five post-gastrectomy patients participated in the present study. Twenty-four hour ambulatory EGG was recorded under normal daily conditions. The DFH of normal controls showed two distinctive peaks, and that of the post-gastrectomy patients, a single peak. The common peak at approximately 1.5 cpm was seen in both DFHs, and the peak at 3 cpm was seen only in the DFH of normal controls. Thus, the common peak was thought to be a product of non-gastric origin. In conclusion, the dominant frequency consists of gastric and non-gastric components which have a specific distribution pattern in the DFH. These findings quantified the contribution of gastric and non-gastric signals to the dominant frequencies in long-term ambulatory EGG. 相似文献
106.
Dihydropyrimidine dehydrogenase activity in 150 healthy Japanese volunteers and identification of novel mutations. 总被引:4,自引:0,他引:4
107.
Two cases of high ulnar nerve neuropathy are reported. Lesions were localized at the midarm level by electrophysiologic studies. In the first case, the lesion was found mainly to be a prolonged neurapraxia, and neurolysis was effective. The ulnar nerve was swollen 1 cm in length under the arcade of Struthers. After neurolysis, the palsy recovered rapidly. In the other case, the lesion seemed to be a mild injury to the myelin sheath. Delayed segmental conduction velocity and partial conduction block were found at the midarm level. The paresis improved slightly during the 11-month followup without any treatment, but the electrophysiologic studies were unchanged. In both cases, physical examination did not distinguish the lesions from cubital tunnel syndrome. Electrophysiologic examination proved to be effective as a diagnostic procedure. In the presence of ulnar neuropathy, the upper arm segment should be included in a routine nerve conduction study to screen for the rare but important entrapment neuropathy caused by the arcade of Struthers. 相似文献
108.
Yamaguchi K Nakagawa S Yabusaki H Nashimoto A 《Gan to kagaku ryoho. Cancer & chemotherapy》2007,34(13):2241-2244
S-1 is currently recognized as one of the standard treatments for advanced and recurrent gastric cancer in Japan. However, there are some patients who can not take oral medication due to pyloric stenosis. We performed a critical evaluation of neoadjuvant chemotherapy (NAC) with paclitaxel (PTX), 5-fluorouracil (5-FU) and cisplatin (CDDP); (PTX+FP) for patients with advanced gastric cancer with pyloric stenosis. Since September 2001, 13 patients with far advanced or non-curative respectable gastric cancer with pyloric stenosis received NAC. These patients were treated with paclitaxel 40 mg/m(2) infusions on days 1 and 8, combined with CDDP (6.5 mg/m(2)) and 5-FU (350 mg/m(2)) on days 1 through 8 followed by 2 weeks rest as one course. After at least 2 courses of treatment, the patients underwent gastrectomy with lymphadectomy. The overall response rate was 38.5% (CR: 0, PR: 5), 7 patients had SD and 1 patient had PD. Seven patients had received staging laparoscopy before NAC and 6 patients had free cancer cells in the peritoneal cavity. Of 6 patients with positive cytology at laparoscopy, 4 had no free cancer cells at operation. The MST was 405 days and one-year survival rate was 55.6%. Toxicities were generally mild, and no serious adverse reactions were observed. There were only 2 cases of grade 3 neutropenia. In conclusion, combination of PTX+FP for NAC appears to be an effective treatment for patients with advanced gastric cancer with pyloric stenosis. 相似文献
109.
110.
Akiko Kawano Takako Eguchi Nakajima Ichiro Oda Nobukazu Hokamura Satoru Iwasa Ken Kato Tetsuya Hamaguchi Yasuhide Yamada Hirofumi Fujii Yasuhiro Shimada 《Gastric cancer》2014,17(1):54-60