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Beena Seema Joshi Nitin Kumar Saqib Kidwai Ramandeep Singh Diwan S. Rawat 《Archiv der Pharmazie》2012,345(11):896-901
A library of unsymmetrical cyclohexane‐1,2‐diamine derivatives were synthesized and evaluated for their activity against Mycobacterium tuberculosis H37Rv in vitro. Out of the 46 compounds synthesized, eight compounds ( 11h , 13a , 13e , 13f , 14a , 14c , 14d , and 15d ) were found to be active at or below 6.25 µM concentration, with negligible toxicity to human red blood cells at a concentration much higher than the MIC99. Compound 13a was the best active compound showing inhibition at 3.125–6.25 µM, and was found to be non‐hemolytic up to 500 µg/mL concentration. 相似文献
43.
Saqib Masroor M.D. M.H.S. Robert Berkowitz M.D. † Karan Nejad M.D. † John C. Alexander M.D. ‡ 《Journal of cardiac surgery》2009,24(2):191-193
Abstract We report a complex case of peripheral vascular disease (PVD), coronary artery disease (CAD), and three prosthetic heart valves, who developed severe mitral regurgitation (MR) due to healed endocarditis. She was successfully managed with a hybrid approach utilizing percutaneous coronary intervention (PCI) followed by minimally invasive mitral valve surgery (MIMVS) through right minithoracotomy. This was the patient's fifth cardiac surgery and she was discharged home on the fourth postoperative day (POD) . 相似文献
44.
This review defines the term "compound allergy" in the context of new findings, and discusses evidence that allergenic reaction products have been identified. Material was gathered by searching Index Medicus and the Science Citation Index, and reviewing several standard texts. Issues regarding the validity of patch lest results are addressed and we introduce the term "pseudcompound allergy" to cover cases of false-negative patch tests. We present new theories regarding the mechanisms by which new allergens arc formed and a means of classification. 相似文献
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We evaluated the medium-term results of combined Chiari pelvic and femoral osteotomies performed at the Manchester Children’s Hospitals between the years 1985 and 1994. The indications for these osteotomies were either hip dislocation or subluxation in children with neuromuscular disease. We clinically and radiologically evaluated 20 hips in 18 patients treated for hip subluxation and dislocation with Chiari osteotomy. The average post-operative clinical follow-up period was 11.32 years (range 10.1–12.9). The mean age at the time of surgery was 7.3 years (range 3.1–13.2 years). Clinically, 9 hips had a ‘Good’ outcome, 10 were “Fair” and 1 was “Poor” according to Osterkamp criteria. At last follow-up, radiologically the mean Sharp’s angle improved from 51° to 44° (p = 0.09), the mean Centre-Edge angle improved from −16° to 18° (p = 0.067), the mean Migration Index improved from 59 to 29 % (p = 0.011), the mean femoral neck-shaft angle from 160° to 117° (p < 0.0001) and the Severin criteria improved from an average grade of 4.5–2.9 (p < 0.0001). Our results compared to previous studies confirm that combined femoral and Chiari osteotomies provide a favourable outcome both clinically and radiologically at least 10 years following surgery. Accepting that the numbers are small, we report no statistical difference in the mean age at the time of operation when comparing the children with an eventual ‘good’ outcome and those with an eventual ‘fair’ or ‘poor’ outcome. 相似文献
48.
Muhammed Z. Khawaja MBBS Manav Sohal MBBS Haseeb Valli MBBS Rafal Dworakowski PhD Stephen J. Pettit PhD David Roy MBBS James Newton MD Heiko Schneider MD Ganesh Manoharan MD Sagar Doshi MD Douglas Muir MD David Roberts MD James Nolan MD Mark Gunning MD Cameron Densem MD Mark S. Spence MD Saqib Chowdhary PhD Vaikom S. Mahadevan MD Stephen J. Brecker MD Philip MacCarthy PhD Michael Mullen MD Rodney H. Stables DM Bernard D. Prendergast DM Adam de Belder MD Martyn Thomas MD Simon Redwood MD David Hildick‐Smith MD 《Catheterization and cardiovascular interventions》2013,81(2):366-373
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Yaseen M Arabi Saqib I Dara Hani M Tamim Asgar H Rishu Abderrezak Bouchama Mohammad K Khedr Daniel Feinstein Joseph E Parrillo Kenneth E Wood Sean P Keenan Sergio Zanotti Greg Martinka Aseem Kumar Anand Kumar 《Critical care (London, England)》2013,17(2):R72
Introduction
Data are sparse as to whether obesity influences the risk of death in critically ill patients with septic shock. We sought to examine the possible impact of obesity, as assessed by body mass index (BMI), on hospital mortality in septic shock patients.Methods
We performed a nested cohort study within a retrospective database of patients with septic shock conducted in 28 medical centers in Canada, United States and Saudi Arabia between 1996 and 2008. Patients were classified according to the World Health Organization criteria for BMI. Multivariate logistic regression analysis was performed to evaluate the association between obesity and hospital mortality.Results
Of the 8,670 patients with septic shock, 2,882 (33.2%) had height and weight data recorded at ICU admission and constituted the study group. Obese patients were more likely to have skin and soft tissue infections and less likely to have pneumonia with predominantly Gram-positive microorganisms. Crystalloid and colloid resuscitation fluids in the first six hours were given at significantly lower volumes per kg in the obese and very obese patients compared to underweight and normal weight patients (for crystalloids: 55.0 ± 40.1 ml/kg for underweight, 43.2 ± 33.4 for normal BMI, 37.1 ± 30.8 for obese and 27.7 ± 22.0 for very obese). Antimicrobial doses per kg were also different among BMI groups. Crude analysis showed that obese and very obese patients had lower hospital mortality compared to normal weight patients (odds ratio (OR) 0.80, 95% confidence interval (CI) 0.66 to 0.97 for obese and OR 0.61, 95% CI 0.44 to 0.85 for very obese patients). After adjusting for baseline characteristics and sepsis interventions, the association became non-significant (OR 0.80, 95% CI 0.62 to 1.02 for obese and OR 0.69, 95% CI 0.45 to 1.04 for very obese).Conclusions
The obesity paradox (lower mortality in the obese) documented in other populations is also observed in septic shock. This may be related in part to differences in patient characteristics. However, the true paradox may lie in the variations in the sepsis interventions, such as the administration of resuscitation fluids and antimicrobial therapy. Considering the obesity epidemic and its impact on critical care, further studies are warranted to examine whether a weight-based approach to common therapeutic interventions in septic shock influences outcome. 相似文献50.