全文获取类型
收费全文 | 1819篇 |
免费 | 112篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 93篇 |
儿科学 | 32篇 |
妇产科学 | 26篇 |
基础医学 | 213篇 |
口腔科学 | 45篇 |
临床医学 | 162篇 |
内科学 | 395篇 |
皮肤病学 | 63篇 |
神经病学 | 95篇 |
特种医学 | 46篇 |
外科学 | 284篇 |
综合类 | 4篇 |
预防医学 | 65篇 |
眼科学 | 89篇 |
药学 | 136篇 |
中国医学 | 9篇 |
肿瘤学 | 180篇 |
出版年
2023年 | 18篇 |
2022年 | 42篇 |
2021年 | 73篇 |
2020年 | 41篇 |
2019年 | 44篇 |
2018年 | 54篇 |
2017年 | 48篇 |
2016年 | 43篇 |
2015年 | 50篇 |
2014年 | 65篇 |
2013年 | 67篇 |
2012年 | 88篇 |
2011年 | 91篇 |
2010年 | 52篇 |
2009年 | 54篇 |
2008年 | 103篇 |
2007年 | 89篇 |
2006年 | 84篇 |
2005年 | 82篇 |
2004年 | 72篇 |
2003年 | 88篇 |
2002年 | 96篇 |
2001年 | 38篇 |
2000年 | 40篇 |
1999年 | 27篇 |
1998年 | 8篇 |
1997年 | 9篇 |
1996年 | 18篇 |
1992年 | 19篇 |
1991年 | 25篇 |
1990年 | 20篇 |
1989年 | 17篇 |
1988年 | 15篇 |
1987年 | 20篇 |
1986年 | 24篇 |
1985年 | 21篇 |
1984年 | 21篇 |
1983年 | 18篇 |
1982年 | 8篇 |
1979年 | 12篇 |
1978年 | 9篇 |
1975年 | 10篇 |
1974年 | 7篇 |
1973年 | 9篇 |
1972年 | 8篇 |
1971年 | 7篇 |
1969年 | 8篇 |
1968年 | 12篇 |
1967年 | 8篇 |
1966年 | 12篇 |
排序方式: 共有1937条查询结果,搜索用时 15 毫秒
31.
Takeshi Masaki Makoto Okazawa Ryotaro Asano Tadakatsu Inagaki Tomohiko Ishibashi Akiko Yamagishi Saori Umeki-Mizushima Manami Nishimura Yusuke Manabe Hatsue Ishibashi-Ueda Manabu Shirai Hirotsugu Tsuchimochi James T Pearson Atsushi Kumanogoh Yasushi Sakata Takeshi Ogo Tadamitsu Kishimoto Yoshikazu Nakaoka 《Proceedings of the National Academy of Sciences of the United States of America》2021,118(11)
32.
33.
Hyperthyroidism and the management of atrial fibrillation. 总被引:5,自引:0,他引:5
Taeko Shimizu Saori Koide Jaduk Yoshimura Noh Kiminori Sugino Kohichi Ito Hiroe Nakazawa 《Thyroid》2002,12(6):489-493
Atrial fibrillation is often induced in patients with hyperthyroidism and may trigger heart failure. Its prevalence and outcome were examined to obtain up-to-date information. Persistent atrial fibrillation was observed in approximately 1.7% of new hyperthyroid patients. It occurs more frequently in males (2.86%) than in females (1.36%), even though the number of male hyperthyroid patients is only one fifth of female patients. The rate increased with age, being 8% in the patients older than 70 years old. The initial treatment is to control the heart rate with routine pharmacologic therapy and to start antithyroid therapy as quickly as possible. Attempted cardioversion should be deferred until approximately the fourth month of maintaining a euthyroid state, because more than 56% of atrial fibrillation spontaneously reverts to sinus rhythm when the thyroid hormone levels start to decline. Elective cardioversion for those whose atrial fibrillation persists is highly effective and sinus rhythm maintenance rates were 56.7% and 47.6% at the 10th and the 14th year, respectively, even though the duration of atrial fibrillation prior to cardioversion was extremely long (35.0 +/- 29.0 months). 相似文献
34.
Saori?KashimaEmail author Takashi?Yorifuji Toshihide?Tsuda Akira?Eboshida 《International archives of occupational and environmental health》2015,88(4):419-430
Purpose
In 1968, rice oil contaminated with polychlorinated biphenyls and polychlorinated dibenzofurans caused a severe outbreak of food poisoning in Japan and was termed locally as “Yusho” (oil disease). In our previous study, we found that area-based standardized mortality ratios (SMRs) of some diseases were elevated shortly after the incident. This previous study, however, was unable to determine whether these elevated SMRs were a result of other area-specific factors. To overcome this limitation, we obtained mortality data from the 5 years before the incident and conducted an area-based study using vital statistics records dating from 1963 to 2002.Methods
The population of Nagasaki Prefecture was set as the reference population for calculating SMRs. We also included data on cause-specific mortality attributable to cancer and expanded the population to encompass two severely exposed areas where contaminated rice oil was distributed (namely Tamanoura and Naru). We also calculated SMRs in the remainder of the Shimo-Goto region, excluding the exposed area, which was used as a comparison area.Results
Even after considering the time trends in mortality before the incident, mortality due to diabetes mellitus and heart disease, as well as all-cause mortality, was found to be elevated shortly afterward. Additionally, mortalities due to uterine cancer in Tamanoura and leukemia were also elevated at 30–34 and 10–59 years after the event in both exposed areas, respectively. SMRs for leukemia in Tamanoura were as high as 3.0 (95 % confidence interval 1.4–6.2) and 2.4 (1.2–4.8) 10–19 years later. In this period, SMRs for leukemia in the comparison area were not elevated.Conclusions
Further epidemiological studies are needed regarding this rice-oil, “Yusho” outbreak, especially with regard to cancer and non-cancer mortality.35.
Kenji Abe Kanayo Kobayashi Saori Yoshino Kyoji Taguchi Hiroshi Nojima 《Drug and chemical toxicology》2015,38(2):167-173
An itch is experientially well known that the scratching response of conditions such as atopic dermatitis is enhanced under psychological stress. Morphine is typical narcotic drug that induces a scratching response upon local application as an adverse drug reaction. Although long-term treatment with morphine will cause tolerance and dependence, morphine withdrawal can cause psychologically and physiologically stressful changes in humans. In this study, we evaluated the effects of morphine withdrawal on histamine-induced scratching behavior in mice. Administration of morphine with progressively increasing doses (10–50?mg/kg, i.p.) was performed for 5 consecutive days. At 3, 24, 48, and 72?hr after spontaneous withdrawal from the final morphine dose, histamine was intradermally injected into the rostral part of the back and then the number of bouts of scratching in 60?min was recorded and summed. We found that at 24?hr after morphine withdrawal there was a significant increase in histamine-induced scratching behavior. The spinal c-Fos positive cells were also significantly increased. The relative adrenal weight increased and the relative thymus weight decreased, both significantly. Moreover, the plasma corticosterone levels changed in parallel with the number of scratching bouts. These results suggest that morphine withdrawal induces a stressed state and enhances in histamine-induced scratching behavior. Increased reaction against histamine in the cervical vertebrae will participate in this stress-induced itch enhancement. 相似文献
36.
Microvascular resistance in response to iodinated contrast media in normal and functionally impaired kidneys 下载免费PDF全文
Osamu Kurihara Masamichi Takano Saori Uchiyama Isamu Fukuizumi Tetsuro Shimura Masato Matsushita Hidenori Komiyama Toru Inami Daisuke Murakami Ryo Munakata Takayoshi Ohba Noritake Hata Yoshihiko Seino Wataru Shimizu 《Clinical and experimental pharmacology & physiology》2015,42(12):1245-1250
Contrast‐induced nephropathy (CIN) is considered to result from intrarenal vasoconstriction, and occurs more frequently in impaired than in normal kidneys. It was hypothesized that iodinated contrast media would markedly change renal blood flow and vascular resistance in functionally impaired kidneys. Thirty‐six patients were enrolled (32 men; mean age, 75.3 ± 7.6 years) undergoing diagnostic coronary angiography and were divided into two groups based on the presence of chronic kidney disease (CKD), defined as an estimated glomerular filtration rate (eGFR) of < 60 mL/min per 1.73 m2 (CKD and non‐CKD groups, n = 18 in both). Average peak velocity (APV) and renal artery resistance index (RI) were measured by Doppler flow wire before and after administration of the iodinated contrast media. The APV and the RI were positively and inversely correlated with the eGFR at baseline, respectively (APV, R = 0.545, P = 0.001; RI, R = ?0.627, P < 0.001). Mean RI was significantly higher (P = 0.015) and APV was significantly lower (P = 0.026) in the CKD than in the non‐CKD group. Both APV (P < 0.001) and RI (P = 0.002) were significantly changed following contrast media administration in the non‐CKD group, but not in the CKD group (APV, P = 0.258; RI, P = 0.707). Although renal arterial resistance was higher in patients with CKD, it was not affected by contrast media administration, suggesting that patients with CKD could have an attenuated response to contrast media. 相似文献
37.
Naoto Ishimaru Jun Ohnishi Hiroyuki Seto Yohei Kanzawa Nobuya Sano Saori Kinami 《Internal medicine (Tokyo, Japan)》2021,60(4):645
A 23-year-old man had an 8-day history of fatigue and dry cough and papulo-nodular reactions on his extensive tattoos. Chest radiography revealed several small granular shadows, and a transbronchial lung biopsy showed non-caseating epithelioid cell granuloma. A skin biopsy of the tattooed area showed histiocytic infiltrates with phagocytized tattoo pigment. Antibody tests for hepatitis C virus were positive. The patient was successfully treated with corticosteroid therapy, and after inflammation was suppressed, he received delayed anti-viral therapy. Sarcoidosis should be considered as a concurrent condition if papules are presented on the tattoos of patients with hepatitis C. 相似文献
38.
39.
K Miki J Takamatsu S Sakane M Majima H Kitaoka A Kitazawa T Mozai S Katayama S Morita A Kobayashi 《Nippon Naibunpi Gakkai zasshi》1987,63(3):184-192
Pathology of the thyroid gland tissue was characterized in patients with Triiodothyronine (T3)-predominant Graves' disease who had normal levels of serum T4 but increased levels of serum T3 during antithyroid drug therapy. In order to compare this group of patients with an usual type of Graves' patients, age, sex, dietary intake of iodide, duration of antithyroid therapy and the dose of thionamide drugs were matched between the two groups of patients. Thyroid tissue was obtained from subtotal thyroidectomy. In examining the histology of the thyroid gland, integration eye piece plate II with regularly arranged 100 lattice points was set on eye lens of a microscope. The number of crossing points which were projected on each 4 histological elements was counted in randomly selected 10 fields of vision in each patient's thyroid. Assuming that the every histological element is arranged in a random manner, errors of each visual field by this method would be less than 12%. In consequence, the significant difference was demonstrated in the weight of subtotally resected thyroid and the ratio of each histological element except interstitial tissue occupied in the total thyroid tissue between T3-predominant Graves' disease and control Graves' disease. The volume composition of the epithelial cells and vacuoles in patients with T3-predominant Graves' disease was significantly greater than that of patients with control Graves' disease (24.7 +/- 10.6 vs 14.4 +/- 6.5%, 5.9 +/- 3.9 vs 2.0 +/- 1.0%, Mean +/- SD, respectively, p less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
40.
Mari Terada Satoshi Kutsuna Tomiteru Togano Sho Saito Noriko Kinoshita Yumiko Shimanishi Tetsuya Suzuki Yusuke Miyazato Makoto Inada Takahito Nakamoto Hidetoshi Nomoto Satoshi Ide Mitsuhiro Sato Kenji Maeda Akihiro Matsunaga Masahiro Satake Keiji Matsubayashi Hirokazu Tsuno Makiko Kojima Madoka Kuramistu Kenta Tezuka Emi Ikebe Kazu Okuma Isao Hamaguchi Katsuyuki Shiratori Motohiko Sato Yuiko Kawakami Kumi Inaba Saori Igarashi Reina Yamauchi Mina Matsumura Keiko Ishimaru Bijuan Zhang Chika Kuge Maiko Ishihara Miho Gouda Keiko Tanaka Yukihito Ishizaka Norio Ohmagari 《Transfusion》2021,61(7):1998-2007