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11.
Boag's theory for the collection efficiency of a small ionisation chamber in a pulsed swept beam is generalised by taking chamber size into account. The collection efficiency is given in terms of the chamber radius, the Gaussian scale constant of the stationary beam, and the maximum distance between beam and chamber centres. It is shown that, for cases of practical interest, collection efficiency is independent of chamber size. 相似文献
12.
M. L. Vizuete M. Santiago A. J. Herrera J. L. Venero A. Machado J. Cano 《Journal of neural transmission (Vienna, Austria : 1996)》1991,85(3):231-242
Summary Levels of dopamine (DA), noradrenaline (NA) and 5-hydroxytryptamine (serotonin, 5-HT) and their metabolites, and the activities of tyrosine hydroxylase (TH), tryptophan hydroxylase (TPH) and monoamine oxidase A and B (MAO-A and MAO-B) have been determined in the rat posterior thalamus after enucleation during postnatal development. DA and 5-HT turnover rate have been measured as 3,4-dihydroxyphenylalanine (DOPA) and 5-hydroxytryptophan (5-HTP) accumulation rates after central decarboxylase inhibition by 3-hydroxybenzylhydrazine (NSD-1015). The major changes were an increase in noradrenergic and serotoninergic metabolism in enucleated animals compared with control animals. A decrease of the MAO-A to MAO-B ratio during postnatal development was found.Abbreviations
DA
dopamine
-
DOPAC
3,4-dihydroxyphenylacetic acid
-
HVA
homovanillic acid
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DOPA
3,4-dihydroxyphenylalanine
-
NA
noradrenaline
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MHPG
3-methoxy-4-hydroxyphenylgly-col
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NMN
normetanephrine
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TRP
tryptophan
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5-HTP
5-hydroxytryptophan
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5-HT
serotonin
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5-HIAA
5-hydroxy-3-indolacetic acid
-
TH
tyrosine hydroxylase
-
TPH
tryptophan hydroxylase
-
MAO-A
monoamine oxidase-A
-
MAO-B
monoamine oxidase-B
Recipients of fellowships from I.I.E. del FISS Reincorporación de doctores y tecnólogos del M.E.C., and Perfeccionamiento de doctores y tecnólogos del MEC, Spain 相似文献
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Dominick Sabatino Santiago Martinez Rosemarie Young Howard Balbi Peter Ciminera Marianne Frieri 《Pediatric hematology and oncology》1991,8(4):355-359
The case of a 7-year-old girl with acquired immunodeficiency syndrome treated for 5 years with AZT and intravenous gamma globulin is reported. Shortly before her demise she developed a pulmonary leiomyosarcoma and leiomyoma. Does prolonged survival in pediatric acquired immune deficiency syndrome increase the incidence of secondary malignancies? 相似文献
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J M Santiago 《Hospital & community psychiatry》1992,43(11):1095-1099
In the second part of a two-part paper, the three major proposals for U.S. health care reform--the government-sponsored model, the employment-based model, and the market reform model--are reviewed. Barriers to their success include the current economic crisis, the lack of a clear consensus, and the high costs of the proposals. Most proposals limit the extent of psychiatric coverage; some exclude such coverage from minimum benefit packages, an area of concern for clinicians. The author concludes that any substantial health care reform is unlikely in the near future. A thoughtful, realistic, and yet vigorous strategic plan is needed now to forestall the possible exclusion of significant mental health coverage. The basic elements of such a plan are reviewed. 相似文献
18.
The effects of quercetin have been investigated on the gastrointestinal propulsion of charcoal meal in mice. Quercetin reduced the rate of intestinal transit and this effect was potentiated by verapamil. 相似文献
19.
Submassive hepatic necrosis associated with the use of progabide: A GABA receptor agonist 总被引:2,自引:0,他引:2
Santiago J. Munoz MD Ruggero Fariello MD Willis C. Maddrey MD 《Digestive diseases and sciences》1988,33(3):375-380
Progabide, a recently introduced gamma-aminobutyric acid mimetic, is currently undergoing clinical evaluation for a variety of convulsive disorders. We describe a patient in whom severe hepatic failure developed after four weeks of Progabide therapy. The patient's course was marked by encephalopathy, jaundice, hypoglycemia, markedly elevated serum aminotransferase levels, and prolongation of the prothrombin time. Liver biopsy showed extensive hepatocellular necrosis. The patient recovered slowly after discontinuation of the drug. The finding of eosinophilia and increased serum IgE suggests an immunologically mediated mechanism for the Progabide-induced hepatic injury. Alternatively, the lipophilic moiety of Progabide may interact with hepatocyte cell membrane lipids leading to toxic injury. We conclude that Progabide may occasionally cause severe hepatic injury. 相似文献
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