全文获取类型
收费全文 | 10151篇 |
免费 | 644篇 |
国内免费 | 24篇 |
专业分类
耳鼻咽喉 | 250篇 |
儿科学 | 750篇 |
妇产科学 | 165篇 |
基础医学 | 1079篇 |
口腔科学 | 134篇 |
临床医学 | 689篇 |
内科学 | 2265篇 |
皮肤病学 | 273篇 |
神经病学 | 1032篇 |
特种医学 | 298篇 |
外科学 | 1426篇 |
综合类 | 177篇 |
一般理论 | 2篇 |
预防医学 | 641篇 |
眼科学 | 177篇 |
药学 | 567篇 |
中国医学 | 15篇 |
肿瘤学 | 879篇 |
出版年
2023年 | 71篇 |
2022年 | 111篇 |
2021年 | 326篇 |
2020年 | 182篇 |
2019年 | 264篇 |
2018年 | 341篇 |
2017年 | 250篇 |
2016年 | 277篇 |
2015年 | 278篇 |
2014年 | 438篇 |
2013年 | 503篇 |
2012年 | 712篇 |
2011年 | 695篇 |
2010年 | 378篇 |
2009年 | 333篇 |
2008年 | 586篇 |
2007年 | 542篇 |
2006年 | 501篇 |
2005年 | 461篇 |
2004年 | 439篇 |
2003年 | 397篇 |
2002年 | 323篇 |
2001年 | 147篇 |
2000年 | 183篇 |
1999年 | 163篇 |
1998年 | 90篇 |
1997年 | 75篇 |
1996年 | 77篇 |
1995年 | 62篇 |
1994年 | 47篇 |
1993年 | 38篇 |
1992年 | 105篇 |
1991年 | 78篇 |
1990年 | 85篇 |
1989年 | 112篇 |
1988年 | 100篇 |
1987年 | 97篇 |
1986年 | 94篇 |
1985年 | 91篇 |
1984年 | 83篇 |
1983年 | 70篇 |
1982年 | 39篇 |
1981年 | 38篇 |
1979年 | 46篇 |
1978年 | 34篇 |
1977年 | 40篇 |
1975年 | 32篇 |
1974年 | 34篇 |
1972年 | 43篇 |
1969年 | 36篇 |
排序方式: 共有10000条查询结果,搜索用时 546 毫秒
81.
Enhanced lung injury and delayed clearance of Pneumocystis carinii in surfactant protein A-deficient mice: attenuation of cytokine responses and reactive oxygen-nitrogen species 下载免费PDF全文
Atochina EN Beck JM Preston AM Haczku A Tomer Y Scanlon ST Fusaro T Casey J Hawgood S Gow AJ Beers MF 《Infection and immunity》2004,72(10):6002-6011
Surfactant protein A (SP-A), a member of the collectin family, selectively binds to Pneumocystis carinii and mediates interactions between pathogen and host alveolar macrophages in vitro. To test the hypothesis that mice lacking SP-A have delayed clearance of Pneumocystis organisms and enhanced lung injury, wild-type C57BL/6 (WT) and SP-A-deficient mice (SP-A(-/-)) with or without selective CD4(+)-T-cell depletion were intratracheally inoculated with Pneumocystis organisms. Four weeks later, CD4-depleted SP-A-deficient mice had developed a more severe Pneumocystis infection than CD4-depleted WT (P. carinii pneumonia [PCP] scores of 3 versus 2, respectively). Whereas all non-CD4-depleted WT mice were free of PCP, intact SP-A(-/-) mice also had evidence of increased organism burden. Pneumocystis infection in SP-A-deficient mice was associated histologically with enhanced peribronchial and/or perivascular cellularity (score of 4 versus 2, SP-A(-/-) versus C57BL/6 mice, respectively) and a corresponding increase in bronchoalveolar lavage (BAL) cell counts. Increases in SP-D content, gamma interferon, interleukin-4, interleukin-5, and tumor necrosis factor alpha in BAL fluid occurred but were attenuated in PCP-infected SP-A(-/-) mice compared to WT mice. There were increases in total BAL NO levels in both infected groups, but nitrite levels were higher in SP-A(-/-) mice, indicating a reduction in production of higher oxides of nitrogen that was also reflected in lower levels of 3-nitrotyrosine staining in the SP-A(-/-) group. We conclude that despite increases in inflammatory cells, SP-A-deficient mice infected with P. carinii exhibit an enhanced susceptibility to the organism and attenuated production of proinflammatory cytokines and reactive oxygen-nitrogen species. These data support the concept that SP-A is a local effector molecule in the lung host defense against P. carinii in vivo. 相似文献
82.
In our sample of 15 hospitalized patients with severe psychotic depression, six responded to therapy with tricyclic antidepressants combined with neuroleptics. Of the nine nonresponders, eight showed an excellent clinical response to electroconvulsive therapy (ECT). The clinical outcome after 6 months of treatment was similar in both groups. We recommend that protracted, complicated trials of pharmacotherapy be reevaluated in psychotic depression. A prospective comparative study of ECT and pharmacotherapy is needed to define the optimal treatment for psychotic depression. 相似文献
83.
Cobb Cory L. Salas-Wright Christopher P. John Rachel Schwartz Seth J. Vaughn Michael Martínez Charles R. Awad Germine Pinedo Miguel Cano Miguel Ángel 《Prevention science》2021,22(3):397-407
Prevention Science - We examined national trends and mental health correlates of discrimination among Latinos in the USA. We used data from two nationally representative surveys based on the... 相似文献
84.
85.
86.
87.
88.
89.
Roger Suau Marta Vidal Ruth Aguilar Gemma Ruiz-Olalla Miquel Vázquez-Santiago Chenjerai Jairoce Augusto J. Nhabomba Ben Gyan David Dosoo Kwaku Poku Asante Seth Owusu-Agyei Joseph J. Campo Luis Izquierdo David Cavanagh Ross L. Coppel Virander Chauhan Evelina Angov Sheetij Dutta Carlota Dobaño 《Vaccine》2021,39(4):687-698
BackgroundThe evaluation of immune responses to RTS,S/AS01 has traditionally focused on immunoglobulin (Ig) G antibodies that are only moderately associated with protection. The role of other antibody isotypes that could also contribute to vaccine efficacy remains unclear. Here we investigated whether RTS,S/AS01E elicits antigen-specific serum IgA antibodies to the vaccine and other malaria antigens, and we explored their association with protection.MethodsNinety-five children (age 5–17 months old at first vaccination) from the RTS,S/AS01E phase 3 clinical trial who received 3 doses of RTS,S/AS01E or a comparator vaccine were selected for IgA quantification 1 month post primary immunization. Two sites with different malaria transmission intensities (MTI) and clinical malaria cases and controls, were included. Measurements of IgA against different constructs of the circumsporozoite protein (CSP) vaccine antigen and 16 vaccine-unrelated Plasmodium falciparum antigens were performed using a quantitative suspension array assay.ResultsRTS,S vaccination induced a 1.2 to 2-fold increase in levels of serum/plasma IgA antibodies to all CSP constructs, which was not observed upon immunization with a comparator vaccine. The IgA response against 13 out of 16 vaccine-unrelated P. falciparum antigens also increased after vaccination, and levels were higher in recipients of RTS,S than in comparators. IgA levels to malaria antigens before vaccination were more elevated in the high MTI than the low MTI site. No statistically significant association of IgA with protection was found in exploratory analyses.ConclusionsRTS,S/AS01E induces IgA responses in peripheral blood against CSP vaccine antigens and other P. falciparum vaccine-unrelated antigens, similar to what we previously showed for IgG responses. Collectively, data warrant further investigation of the potential contribution of vaccine-induced IgA responses to efficacy and any possible interplay, either synergistic or antagonistic, with protective IgG, as identifying mediators of protection by RTS,S/AS01E immunization is necessary for the design of improved second-generation vaccines.Clinical trial registration: ClinicalTrials.gov: NCT008666191. 相似文献
90.
Bhatia K Spangler G Advani S Kamel A Hamdy N Iyer R Aplan P Magrath I 《International journal of oncology》1993,2(5):725-730
SCL gene rearrangement is the most common molecular lesion (25%) identified so far in T-cell acute lymphoblastic leukemia (T-ALL). Since the frequency of T-ALL appears to be relatively higher in developing countries, we wished to determine as to what fraction of T-ALL from this population harbor SCL rearrangements. We show in this study that although the overall frequency of SCL/SIL rearrangements in T-ALL is similar to the Western countries this is at the expense of increased type A rearrangements. Whether the paucity of type B rearrangements reflects a difference in disease etiology in this part of the world is to be determined. 相似文献