收费全文 | 5764篇 |
免费 | 515篇 |
国内免费 | 10篇 |
耳鼻咽喉 | 69篇 |
儿科学 | 182篇 |
妇产科学 | 156篇 |
基础医学 | 809篇 |
口腔科学 | 53篇 |
临床医学 | 785篇 |
内科学 | 1034篇 |
皮肤病学 | 116篇 |
神经病学 | 626篇 |
特种医学 | 140篇 |
外科学 | 606篇 |
综合类 | 54篇 |
一般理论 | 5篇 |
预防医学 | 714篇 |
眼科学 | 131篇 |
药学 | 356篇 |
中国医学 | 6篇 |
肿瘤学 | 447篇 |
2024年 | 16篇 |
2023年 | 128篇 |
2022年 | 171篇 |
2021年 | 442篇 |
2020年 | 259篇 |
2019年 | 349篇 |
2018年 | 339篇 |
2017年 | 267篇 |
2016年 | 294篇 |
2015年 | 243篇 |
2014年 | 310篇 |
2013年 | 375篇 |
2012年 | 469篇 |
2011年 | 494篇 |
2010年 | 234篇 |
2009年 | 197篇 |
2008年 | 304篇 |
2007年 | 268篇 |
2006年 | 241篇 |
2005年 | 221篇 |
2004年 | 172篇 |
2003年 | 183篇 |
2002年 | 156篇 |
2001年 | 27篇 |
2000年 | 14篇 |
1999年 | 18篇 |
1998年 | 24篇 |
1997年 | 8篇 |
1996年 | 9篇 |
1995年 | 5篇 |
1994年 | 7篇 |
1993年 | 6篇 |
1992年 | 2篇 |
1991年 | 8篇 |
1990年 | 7篇 |
1989年 | 1篇 |
1988年 | 5篇 |
1987年 | 1篇 |
1986年 | 1篇 |
1985年 | 3篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 1篇 |
1981年 | 2篇 |
1980年 | 2篇 |
1979年 | 1篇 |
1977年 | 1篇 |
1971年 | 1篇 |
The COVID-19 pandemic and the mitigation measures put in place have resulted in universal disruption in the usual ways of life for individuals. The current study sought to investigate how aspects of sexual health (well-being and functioning) and relationship satisfaction changed or remained stable during the pandemic. During two separate time points (Time 1 including Time 1 and a retrospective baseline, Time 2), participants completed online measures of sexual well-being (sexual pleasure, partnered and solitary orgasm frequency, sexual distress), sexual functioning, and relationship satisfaction. Participants reported slight declines in sexual pleasure, frequency of orgasms with a partner, and frequency of solitary orgasms from pre-COVID-19 (retrospective baseline) to Time 1, with no significant differences in sexual distress and relationship satisfaction. For individuals with vulvas, sexual functioning improved from Time 1 to Time 2, whereas no significant differences in sexual functioning were observed for individuals with penises. Aspects of sexual health and relational satisfaction did not sufficiently change across time points to be considered meaningful health outcome changes. Given that minimal disruptions were noted in pre-COVID-19 to COVID-19 sexuality, these results highlight the potential resiliency of individuals’ sexuality when facing sudden changes in their daily lives. Implications of COVID-19’s effects on sexual well-being and relationship satisfaction research are broadly discussed.
相似文献Materials and Methods: Between October 1987 and December 1995, 506 patients with clinically localized prostate cancer were treated with definitive radiotherapy at UCSF and affiliated institutions. Treatment consisted of 4-field whole pelvic irradiation followed by a prostate-only boost, or prostate-only treatment (median follow-up was 35 months and 30 months, respectively). PSA failure was defined as: 1. a PSA value ≥ 1 ng/ml; or 2. a PSA value that rose ≥ 0.5 ng/ml in ≤ 1 year posttreatment on two consecutive measurements, with the first rise defined as the time of failure. The calculated risk of lymph node positivity (%rLN+) was defined as (iPSA) + 10(GS-6), and high risk was defined as %rLN+ ≥ 15%. Univariate and multivariate analyses were performed.
Results: A total of 201 high-risk patients were identified. High-risk patients who received whole pelvic irradiation had significantly improved freedom from PSA failure compared to those who received prostate-only treatment (median PFS = 34.3 months vs. 21.0 months; p = 0.0001). Potential confounding variables, including initial PSA, Gleason score, T stage, radiation dose, year of treatment, use of three-dimensional (3D) conformal techniques, and use of hormone therapy, did not account for the observed difference in time to PSA failure. Multivariate analysis revealed type of radiation treatment to be the most significant independent predictor of outcome.
Conclusion: Whole pelvic radiotherapy significantly improves the PSA failure-free survival in patients with a high calculated risk of lymph node positivity. 相似文献