全文获取类型
收费全文 | 1695篇 |
免费 | 138篇 |
国内免费 | 18篇 |
专业分类
耳鼻咽喉 | 5篇 |
儿科学 | 62篇 |
妇产科学 | 28篇 |
基础医学 | 150篇 |
口腔科学 | 30篇 |
临床医学 | 153篇 |
内科学 | 486篇 |
皮肤病学 | 8篇 |
神经病学 | 88篇 |
特种医学 | 122篇 |
外科学 | 371篇 |
综合类 | 14篇 |
预防医学 | 157篇 |
眼科学 | 6篇 |
药学 | 94篇 |
中国医学 | 1篇 |
肿瘤学 | 76篇 |
出版年
2023年 | 9篇 |
2022年 | 16篇 |
2021年 | 31篇 |
2020年 | 23篇 |
2019年 | 29篇 |
2018年 | 41篇 |
2017年 | 44篇 |
2016年 | 32篇 |
2015年 | 31篇 |
2014年 | 47篇 |
2013年 | 79篇 |
2012年 | 78篇 |
2011年 | 80篇 |
2010年 | 63篇 |
2009年 | 47篇 |
2008年 | 66篇 |
2007年 | 94篇 |
2006年 | 57篇 |
2005年 | 61篇 |
2004年 | 72篇 |
2003年 | 52篇 |
2002年 | 59篇 |
2001年 | 61篇 |
2000年 | 65篇 |
1999年 | 57篇 |
1998年 | 18篇 |
1997年 | 21篇 |
1996年 | 22篇 |
1995年 | 19篇 |
1994年 | 22篇 |
1993年 | 16篇 |
1992年 | 43篇 |
1991年 | 42篇 |
1990年 | 27篇 |
1989年 | 34篇 |
1988年 | 25篇 |
1987年 | 33篇 |
1986年 | 20篇 |
1985年 | 31篇 |
1984年 | 29篇 |
1983年 | 20篇 |
1982年 | 10篇 |
1981年 | 12篇 |
1980年 | 6篇 |
1979年 | 24篇 |
1978年 | 12篇 |
1973年 | 8篇 |
1972年 | 10篇 |
1971年 | 5篇 |
1970年 | 6篇 |
排序方式: 共有1851条查询结果,搜索用时 0 毫秒
41.
Zerbo Stefania Bilotta Clio Perrone Giulio Malta Ginevra Re Giuseppe Lo Terranova Maria Chiara Argo Antonina Salerno Sergio 《International journal of legal medicine》2021,135(3):893-901
International Journal of Legal Medicine - The motor vehicle crash (MVC) constitutes an important challenge for forensic pathology in order to identify the manner and cause of death. Our study... 相似文献
42.
Maria Diletta Pezzani Barbara Tornimbene Carmem Pessoa-Silva Marlieke de Kraker Sebastiano Rizzardo Nicola Duccio Salerno Stephan Harbarth Evelina Tacconelli 《Clinical microbiology and infection》2021,27(5):687-696
BackgroundThe health impact of antimicrobial resistance (AMR) has not been included in the Global Burden of Disease (GBD) report, as reliable data have been lacking. AMR burden estimates have been derived from models combining incidence and/or prevalence data from national and/or international surveillance systems and mortality estimates from clinical studies. Depending on utilized empirical data, statistical methodology and applied endpoints, the validity and reliability of results can differ substantially.ObjectivesWe assessed comprehensiveness, and internal and external validity of studies estimating the clinical impact of infections caused by the priority antibiotic resistant pathogens monitored by the WHO Global Antimicrobial Resistance Surveillance System.Data sourcesOvid MEDLINE, January 1950 to March 2019, In-Process and other non-indexed citations were searched.Study eligibility criteriaStudies reporting mortality, length of hospital stay, duration of the disease until remission and/or death, complications, hospital re-admissions, and follow-up beyond hospital discharge were eligible.MethodsThe literature was searched according to the Cochrane recommendations and reported according to Preferred Reporting Items for Systematic Reviews.ResultsTwo-hundred and eighty-six studies out of 3529 were eligible. Studies derived mainly from high-income countries (215, 75%) and relied on data from retrospective (226, 79%), single-centre (201, 70%), cohort studies (243, 85%). The health impact was mostly limited to all-cause mortality (128, 45%) with heterogeneity in timing of assessment; attributable length of hospital stay was seldom adjusted for pre-infection admission time and a few studies had enough follow-up for assessing long-term sequelae. Overall, adjustment for confounding has shown a substantial improvement. Data on health state definitions and duration of diseases are generally lacking, precluding calculation of disability-adjusted life years, critical for application of the GBD study methodology.ConclusionEfforts to improve harmonization, representativeness, quality of AMR surveillance data and cohort studies to determine AMR attributable mortality and morbidity are urgently required. Policy makers need accurate and detailed burden estimates to inform prioritization of resource allocation, and to select the most effective intervention strategies to halt the AMR crisis. 相似文献
43.
Colao A Di Somma C Rota F Di Maio S Salerno M Klain A Spiezia S Lombardi G 《The Journal of clinical endocrinology and metabolism》2005,90(5):2659-2665
We prospectively investigated the risk of early atherosclerosis, by classical cardiovascular risk factors and intima-media thickness (IMT) at the common carotid arteries, in 23 adolescents diagnosed as GH deficient (GHD) during childhood and in 23 healthy sex-, age-, and BMI-matched controls. Measurements were performed in all subjects before stopping GH replacement. Because the diagnosis of GHD had been confirmed in 15 of the 23 adolescents, the protocol changed according to the diagnosis as follows: measurements were repeated after 6 months of GH withdrawal and 6 months of GH reinstitution in the 15 with GHD, and after 6 and 12 months of GH withdrawal, measurements were also taken in the eight non-GHD subjects. Serum IGF-I levels were in the normal range for age in all patients before GH withdrawal. When compared with controls, before GH withdrawal, GHD adolescents had reduced high-density lipoprotein cholesterol levels and increased total/high-density lipoprotein cholesterol ratio, fibrinogen, low-density lipoprotein cholesterol, and glucose levels; non-GHD adolescents had increased glucose, insulin, and homeostasis model assessment score. IMT at the common carotid arteries was similar in GHD and controls (0.52 +/- 0.03 vs. 0.55 +/- 0.06 mm; P = 0.23) and was higher in non-GHD than in controls (0.62 +/- 0.03 vs. 0.54 +/- 0.06 mm; P = 0.01). In GHD adolescents, 6 months of GH treatment withdrawal and 6 months of GH treatment reinstitution modified IGF-I levels, lipid profile, and insulin resistance but not IMT or systolic and diastolic peak velocities at the common carotid arteries. In non-GHD subjects, 12 months of GH treatment withdrawal significantly decreased IGF-I levels, IMT (to 0.54 +/- 0.06 mm; P < 0.001 vs. baseline), systolic and diastolic peak velocities, and improved insulin resistance. In conclusion, the discontinuation of GH in confirmed GHD adolescents is not followed by significant alterations of the common carotid arteries, despite the profound negative alterations of the lipid profile. In adolescents who were not confirmed to have GHD, IMT was increased while on GH therapy and normalized when they were taken off of GH. 相似文献
44.
Immunologic status of hemophilia patients treated with cryoprecipitate or lyophilized concentrate 总被引:1,自引:0,他引:1
We evaluated 37 patients with moderate or severe hemophilia A and six patients with severe factor IX deficiency for clinical or laboratory evidence of immune abnormalities. Patients were assigned to one of four groups according to the type of clotting factor replacement. Twenty patients had received only cryoprecipitate during the two years preceding the evaluation (group I); 11 additional patients were treated predominantly with cryoprecipitate but had also received up to nine bottles of factor VIII concentrate (group II); six patients received factor VIII concentrate (group III); six patients received factor IX concentrate (group IV). There was no clinical or laboratory evidence of immunodeficiency among the 43 patients. The mean absolute number of Th cells was normal in all patient groups, but the mean absolute number of Ts cells was increased compared with controls, both in patients treated with cryoprecipitate and in patients treated with factor VIII or factor IX concentrate. There was no correlation between the Th/Ts ratio and patient age, alanine aminotransferase level, hepatitis serology, in vitro lymphocyte function, or amount of clotting factor administered. Our observations demonstrate that the volunteer or commercial origin of clotting factor replacement cannot fully explain the alterations in lymphocyte subset distribution previously described in patients with hemophilia A. 相似文献
45.
Dieli F Sireci G Caccamo N Di Sano C Titone L Romano A Di Carlo P Barera A Accardo-Palumbo A Krensky AM Salerno A 《The Journal of infectious diseases》2002,186(12):1835-1839
Vgamma9/Vdelta2 T cells can contribute to protective immune response against Mycobacterium tuberculosis, although the extent to which and mechanisms by which they could actually protect against human tuberculosis remain unclear. We have previously reported that Vgamma9/Vdelta2 T cells from tuberculin purified protein derivative (PPD)-positive children, either healthy or affected by different clinical forms of tuberculosis, strongly proliferate to different phosphoantigens in vitro, whereas Vgamma9/Vdelta2 T cells from PPD-negative healthy subjects proliferate very poorly. We report here that Vgamma9/Vdelta2 T cells from tuberculous children have an increased proliferative activity, but decreased interferon (IFN)-gamma production and granulysin expression. After successful chemotherapy, the Vgamma9/Vdelta2 T cell proliferative response strongly decreased, whereas IFN-gamma and granulysin production consistently increased. Disease-associated changes in Vgamma9/Vdelta2 T cell effector functions in patients with tuberculosis are consistent with the possibility that these T cells may play a protective role in immune response against M. tuberculosis infection. 相似文献
46.
Laura De La Higuera Emma Riva Codjo Djignefa Djade Sara Mandelli Carlotta Franchi Alessandra Marengoni Francesco Salerno Salvatore Corrao Luca Pasina Mauro Tettamanti Maura Marcucci Pier Mannuccio Mannucci Alessandro Nobili 《Internal and emergency medicine》2014,9(7):735-747
A multicenter observational study, REPOSI (REgistro POliterapie Società Italiana di Medicina Interna), was conducted to assess the prognostic value of glomerular filtration rate (eGFR) on in-hospital mortality, hospital re-admission and death within 3 months, in a sample of elderly patients (n = 1,363) admitted to 66 internal medicine and geriatric wards. Based on eGFR, calculated by the new Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, subjects at hospital admission were classified into three groups: group 1 with normal eGFR (≥60 ml/min/1.73 m2, reference group), group 2 with moderately reduced eGFR (30–59 ml/min/1.73 m2) and group 3 with severely reduced eGFR (<30 ml/min/1.73 m2). Patients with the lowest eGFR (group 3) on admission were more likely to be older, to have a greater cognitive and functional impairment and a high rate of comorbidities. Multivariable logistic regression analysis showed that severely reduced eGFR at the time of admission was associated with in-hospital mortality (OR 3.00; 95 % CI 1.20–7.39, p = 0.0230), but not with re-hospitalization (OR 0.97; 95 % CI 0.54–1.76, p = 0.9156) or mortality at 3 months after discharge (OR 1.93; 95 % CI 0.92–4.04, p = 0.1582). On the contrary, an increased risk (OR 2.60; 95 % CI 1.13–5.98, p = 0.0813) to die within 3 months after discharge was associated with decreased eGFR measured at the time of discharge. Our study demonstrates that severely reduced eGFRs in elderly patients admitted to hospital are strong predictors of the risk of dying during hospitalization, and that this measurement at the time of discharge helps to predict early death after hospitalization. 相似文献
47.
Giuseppe Limongelli Teo Roselli Giuseppe Pacileo Paolo Calabró Valeria Maddaloni Daniele Masarone Lucia Riegler Rita Gravino Raffaella Scarafile Gemma Salerno Tiziana Miele Antonello D’Andrea Lucio Santangelo Massimo Romano Giovanni Di Salvo Maria Giovanna Russo Raffaele Calabró 《Internal and emergency medicine》2014,9(1):43-50
Cardiotrophin-1 (CT-1) is a member of the interleukin (IL-6) family of cytokines. Plasma CT-1 levels correlate with the left ventricle mass index in patients with dilatated cardiomyopathy and congestive heart failure (CHF). The aim of this paper was to evaluate CT-1 plasma levels, before and after cardiac resynchronization therapy CRT, and to characterizeits prognostic role in patients with CHF. Fifty-two consecutive patients (M/F = 39/13; 56 ± 11 years old) underwent clinical and echocardiographic evaluation, and blood sample collection at baseline. The same evaluation was repeated 6.4 ± 0.79 months after CRT. Patients with a decreased LV end-systolic volume by at least 15% (reverse remodeling) were considered echo responders to CRT. Twenty-nine patients (56%) were responders to CRT. After CRT, only 15 patients (29%) showed increased CT-1 after CRT. They were all non responders to CRT. A multivariate, logistic modelshowed CT-1 as an independent predictor of CRT echo response (p = 0.005; OR 0.97). During follow-up (18 ± 7 months), 21 cardiac events in 18 patients occurred. A Cox multivariable model showed plasma BNP pre-CRT (p = 0.02; CI 1.2–5.6; OR 3.1) and CT1 post-CRT (p = 0.01; CI 1.4–4.3; OR 2.7) as independent predictors of cardiac events. Analysis of CT-1 plasma levels deserves future consideration for larger, longitudinal studies in patients with CHF. 相似文献
48.
49.
50.