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排序方式: 共有768条查询结果,搜索用时 15 毫秒
71.
Twelve cases of eccrine porocarcinoma have been reported at our facility in the past 10 years. All of them were Japanese; half had lymph node metastases; and one-third died of this disease. Lymph node metastasis was correlated with pathological lymphovascular invasion. Death was correlated with a pathological growth pattern and clinical lymph node metastasis. Sentinel lymph node biopsy was performed usefully in two patients. 相似文献
72.
73.
Hisashi Uhara Yu-Lai Wang Sachiyo Matsumoto Shigeo Kawachi Toshiaki Saida 《Journal of cutaneous pathology》1995,22(2):146-148
The α subunit of guanine nucleotide-binding protein Go (Go α), which was initially isolated from bovine brain, interacts with muscarinic cholinergic receptors and regulates neuronal calcium channels. Go α is known to be localized in neural tissues, some endocrine cells, and neuroendocrine tumors. We have immunohistochemically investigated the expression of Go α in 4 cases of Merkel cell carcinoma using the method of microwave treatment. In all cases of Merkel cell carcinoma, Go α was consistently detected on the plasma membrane and cytoplasm of the tumor cells. Nerve fibers in the skin were also positive for Go α, but other epidermal or dermal components such as keratinocytes, melanocytes, fibroblasts, or lymphoid cells were negative. Tumor cells of squamous cell carcinoma, cutaneous lymphoma, sweat gland carcinoma, and malignant melanoma were negative for Go 4aL. The present study indicates that Go α may be a useful immunohistochemical marker of Merkel cell carcinoma. 相似文献
74.
Evaluation of treatment of lung cancer combined with the disease which has needed a semi-emergency operation 总被引:1,自引:0,他引:1
M Kadokura N Tanio H Yokokawa K Saida H Kazuma M Kume S Sekiguchi S Yamamoto T Takaba 《Kyobu geka. The Japanese journal of thoracic surgery》1991,44(7):558-561
Six cases of lung cancer combined with the disease which has needed semi-emergency operation, two cases of unstable angina, two of ileus due to colon cancer, one of impending rupture of abdominal aortic aneurysm and one of purulent cholecystitis with cholelithiasis, were discussed. Mean age was 62.0 years (range, 36 to 73); four were male and two were female. Case 1 and 2 were admitted with anterior chest pain, Case 3 with lumbago and abdominal pain, Case 4 and 5 with an abnormal shadow on chest x-ray film and Case 6 with abdominal pain. Of the two with unstable angina, one was operated on with right upper lobectomy during the first months after aorto-coronary bypass. Of the two with colon cancer, one was operated on with right upper lobectomy during about 5 weeks after right hemi-colectomy. Case 3 with abdominal aortic aneurysm operated on with left upper lobectomy during 4 weeks after replacement of abdominal aorta. Case 4 with cholecystitis was operated on with left pneumonectomy during about 3 weeks after cholecystectomy. The postoperative course of 4 cases and the post-chemotherapy condition of 2 cases were uneventful. 相似文献
75.
Shigekazu Kuroki Takahiko Saida Massafumi Nukina Tsunekazu Haruta Mieko Yoshioka Yutaka Kobayashi Hisao Nakanishi 《Annals of neurology》1993,33(3):243-247
Campylobactor jejuni was isolacted from stool cultures from 14(30%) of 46 partients with Guillain-Barré syndrome and from 6(1.2%) of healthy persons, and the difference was highly significant (P<0.0001). In addition, serological evidence of recent. C. Jejuni infection. Ten of 12(83%) isolated from partients with Guillain-Barré syndrome belonged to Penner serogroup 19, which is a rare serogroup in sporadic patients with C. Jejuni enterties. In the lection typing stude, all serogroup 19 strains from patients with Guillain-Barré syndrome patients with Guillain-Barré syndrome were shown to contain terminal b?-N-acetylglucosamine residues on their cell surface, bur serogroup 19 strains from patients with enteritis were not. 相似文献
76.
77.
Newborn F344 rats were injected intraperitoneally with PVC441 virus, a neuropathogenic variant of Friend murine leukemia
virus, and developed paraparesis of hind limbs 35–40 days after infection. Immunohistochemical study using monoclonal anti-PVC441
antibody revealed that in the central nervous system endothelial cells but not neuronal or glial cells were infected with
PVC441 virus. The major pathological changes were myelin vacuolation and oligodendrocyte degeneration in the white matter
at the white-gray border zone. Anterior and lateral funiculi and intercalated myelin of anterior horns were dominantly affected
in the spinal cord from the sacral to cervical level. The midbrain was also vacuolated. An ultrastructural study demonstrated
that many viral particles were present outside the endothelial cells but only sparsely inside endothelial cells and pericytes.
Endothelial cell membranes and tight junctions were also disrupted. Immunohistochemical studies with antibodies against major
histocompatibility complex class Ia, intercellular adhesion molecule-I, glial fibrillary acidic protein, neurofilament protein,
CD3 and OX42 revealed the presence of abundant microglia but not of lymphocytes or polymorphonuclear cells in the lesions.
Axonal degeneration and astrogliosis were mild in degree. These pathological changes explain the observed spastic paraparesis
in the rats, and represent a good model of spongiform diseases of the human central nervous system of retroviral origin, such
as human T cell leukemia virus-associated myelopathy and AIDS.
Received: 4 March 1996 / Revised, accepted: 8 October 1996 相似文献
78.
79.
Human and simian glial cells infected by human T-lymphotropic virus type I in culture 总被引:5,自引:0,他引:5
Although human T-lymphotropic virus type I (HTLV-I) has been implicated in the etiology of tropical spastic paraparesis (TSP) and HTLV-I associated myelopathy (HAM), the direct infectivity of the virus against constituent cells in the central nervous system remains undetermined. To investigate the neurotropism of HTLV-I, we exposed cultured human and simian glial cells to HTLV-I. Primary mixed glial cell cultures of astrocytes and oligodendrocytes were obtained from adult human and cynomolgus monkey (Macaca fascicularis) brains by an enzyme digestion-Percoll gradient method. After two weeks in vitro, the cells were co-cultured with irradiated MT-2 cells, an HTLV-I-producing T-cell line. Cultures were double stained with antibodies against cell-type specific markers and anti-HTLV-I p19 (gag) monoclonal antibody. The HTLV-I antigen was demonstrated in small numbers of glial fibrillary acidic protein-positive cells (astrocytes) and galactocerebroside-positive cells (oligodendrocytes) in both the human and simian cultures. Electron microscopy demonstrated the presence of type C virus-like particles in the cytoplasm of astrocytes. These results indicate that HTLV-I is capable of infecting human and simian glial cells in vitro. 相似文献
80.
Takeshi Ikeuchi Tomoya Asaka Masaaki Saito Hajime Tanaka Sari Higuchi Keiko Tanaka Kyoko Saida Eiichiro Uyama Hidenobu Mizusawa Nobuyoshi Fukuhara Ikuya Nonaka Masaharu Takamori Shoji Tsuji 《Annals of neurology》1997,41(4):432-437
Distal myopathy with rimmed vacuoles is an autosomal recessive muscular disorder, characterized clinically by weakness of the distal muscles in the lower limbs in early adulthood. Recently, the gene locus for familial vacuolar myopathy with autosomal recessive inheritance (hereditary inclusion body myopathy) was mapped to chromosome 9 by genome-wide linkage analysis of nine Persian-Jewish families. Since both disease conditions share similar clinical, genetic, and histopathological features, we analyzed seven families with distal myopathy with rimmed vacuoles using ten microsatellite markers within the region of the hereditary inclusion body myopathy locus. Significantly high cumulative pairwise lod scores were obtained with three markers: D9S248 (Zmax = 5.90 at Θ = 0), D9S43 (Zmax = 5.25 at Θ = 0), and D9S50 (Zmax = 4.23 at Θ = 0). Detection of obligate recombination events as well as multipoint linkage analysis revealed that the most likely location of the distal myopathy with rimmed vacuoles gene is in a 23.3-cM interval defined by D9S319 and D9S276 on chromosome 9. The results raise the possibility that distal myopathy with rimmed vacuoles and hereditary inclusio body myopathy in Persian Jews are allelic diseases. 相似文献