全文获取类型
收费全文 | 1337139篇 |
免费 | 96017篇 |
国内免费 | 2933篇 |
专业分类
耳鼻咽喉 | 19766篇 |
儿科学 | 40294篇 |
妇产科学 | 38796篇 |
基础医学 | 187436篇 |
口腔科学 | 39918篇 |
临床医学 | 112849篇 |
内科学 | 263071篇 |
皮肤病学 | 30281篇 |
神经病学 | 106510篇 |
特种医学 | 53771篇 |
外国民族医学 | 435篇 |
外科学 | 208793篇 |
综合类 | 31094篇 |
现状与发展 | 6篇 |
一般理论 | 436篇 |
预防医学 | 92126篇 |
眼科学 | 31440篇 |
药学 | 100209篇 |
4篇 | |
中国医学 | 2990篇 |
肿瘤学 | 75864篇 |
出版年
2018年 | 11820篇 |
2015年 | 11965篇 |
2014年 | 16795篇 |
2013年 | 25401篇 |
2012年 | 33209篇 |
2011年 | 35088篇 |
2010年 | 20837篇 |
2009年 | 20326篇 |
2008年 | 33785篇 |
2007年 | 36932篇 |
2006年 | 37478篇 |
2005年 | 36243篇 |
2004年 | 35264篇 |
2003年 | 34201篇 |
2002年 | 33697篇 |
2001年 | 63674篇 |
2000年 | 65366篇 |
1999年 | 55434篇 |
1998年 | 14656篇 |
1997年 | 13469篇 |
1996年 | 12945篇 |
1995年 | 12229篇 |
1994年 | 11467篇 |
1992年 | 42773篇 |
1991年 | 41295篇 |
1990年 | 40562篇 |
1989年 | 39558篇 |
1988年 | 36970篇 |
1987年 | 36409篇 |
1986年 | 34901篇 |
1985年 | 33101篇 |
1984年 | 24822篇 |
1983年 | 21053篇 |
1982年 | 12664篇 |
1981年 | 11568篇 |
1980年 | 10773篇 |
1979年 | 23924篇 |
1978年 | 17070篇 |
1977年 | 14836篇 |
1976年 | 13386篇 |
1975年 | 15267篇 |
1974年 | 18080篇 |
1973年 | 17560篇 |
1972年 | 16810篇 |
1971年 | 15717篇 |
1970年 | 14914篇 |
1969年 | 14346篇 |
1968年 | 13460篇 |
1967年 | 12015篇 |
1966年 | 11258篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
21.
22.
Senem Maral Muradiye Acar Ozlem Sahin Balcik Eyyup Uctepe Omer Faruk Hatipoglu Derya Akdeniz Hatice Uludag Altun Ali Kosar Mehmet Gunduz Esra Gunduz 《Medicine》2015,94(16)
Chronic myeloproliferative disorders such as polycythemia vera (PV), essential thrombocytosis (ET), and idiopathic myelofibrosis arise from clonal proliferation of neoplastic stem cells in the bone marrow. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that have potential to degrade all types of extracellular matrix (ECM) and also play a role in remodeling of the ECM. It is known that MMPs play a role in bone marrow remodeling.The primary goal of our study is to explore the relationship between chronic myeloproliferative diseases and some of MMP gene polymorphisms. The demonstration of a relationship will help to understand whether these polymorphisms may be a potential early diagnosis marker of the diseases.Patients were selected from outpatient clinics of Turgut Ozal University Hospital, Ankara, Turkey, between December 2010 and May 2011. Twenty-eight patients that previously diagnosed and followed-up with PV, 17 with secondary polycythemia (SP), and 12 with ET were enrolled in the study, along with a control group of 22 healthy people.DNA was isolated from peripheral blood. Using polymerase chain reaction–restriction fragment length polymorphism method, MMP2 and MMP9 gene polymorphisms were analyzed with agarose gel electrophoresis. There was a statistically significant difference between the study groups and the control group in terms of Gln279Arg polymorphisms rates of MMP9. The highest MMP9 Gln279Arg polymorphism rate was observed in the ET group. But nobody from the control group had polymorphic MMP9. There was no statistically significant difference between the groups in terms of MMP2-735 C > T polymorphism rates.In conclusion, MMP9 gene Gln279Arg polymorphism was associated with ET, SP, and PV diseases. Hence, we believe that these gene polymorphisms may play a role in the mechanism of bone marrow fibrosis and may be a factor that increases the risk of thrombosis. Illumination of the molecular basis of the relationship between MMP-thrombosis and MMP-fibrosis provides a better understanding of the pathophysiology of PV and ET diseases and will allow new approaches to diagnosis and treatment. 相似文献
23.
Autoimmune comorbid diseases associated with lichen planus: a nationwide case–control study
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
24.
Pradeep Balasubramanian M.D. C. R. Srinivas M.D. Pavai Arunachalam M.S. M.Ch. K. S. Thirumurthy M.S. M.Ch. P. R. Rajkumar M.S. M.Ch. H. Manuvidhya M.B.B.S. 《Pediatric dermatology》2015,32(3):e78-e81
We report on a child with several café au lait spots in association with a lumbar lipomeningomyelocele as an apparently new association. Cutaneous markers, the identification of which plays a crucial role in the early diagnosis and management of spinal malformations, can accompany occult spinal dysraphism. Herein we report a case of lumbar lipomeningomyelocele associated with an overlying café au lait spot that served as a marker of occult spinal dysraphism. The patient also had segmental café au lait spots on the face, making the association unique. 相似文献
25.
Loss‐of‐function mutations in the gene encoding filaggrin underlie a Japanese family with food‐dependent exercise‐induced anaphylaxis
下载免费PDF全文
![点击此处可从《Journal of the European Academy of Dermatology and Venereology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
26.
Y.R. Song B. Wu Y.T. Yang J. Chen L.J. Zhang Z.W. Zhang H.Y. Shi C.L. Huang J.X. Pan P. Xie 《Brazilian journal of medical and biological research》2015,48(11):973-982
Bipolar disorder (BD) is a common psychiatric mood disorder affecting more than 1-2%
of the general population of different European countries. Unfortunately, there is no
objective laboratory-based test to aid BD diagnosis or monitor its progression, and
little is known about the molecular basis of BD. Here, we performed a comparative
proteomic study to identify differentially expressed plasma proteins in various BD
mood states (depressed BD, manic BD, and euthymic BD) relative to healthy controls. A
total of 10 euthymic BD, 20 depressed BD, 15 manic BD, and 20 demographically matched
healthy control subjects were recruited. Seven high-abundance proteins were
immunodepleted in plasma samples from the 4 experimental groups, which were then
subjected to proteome-wide expression profiling by two-dimensional electrophoresis
and matrix-assisted laser desorption/ionization-time-of-flight/time-of-flight tandem
mass spectrometry. Proteomic results were validated by immunoblotting and
bioinformatically analyzed using MetaCore. From a total of 32 proteins identified
with 1.5-fold changes in expression compared with healthy controls, 16 proteins were
perturbed in BD independent of mood state, while 16 proteins were specifically
associated with particular BD mood states. Two mood-independent differential
proteins, apolipoprotein (Apo) A1 and Apo L1, suggest that BD pathophysiology may be
associated with early perturbations in lipid metabolism. Moreover, down-regulation of
one mood-dependent protein, carbonic anhydrase 1 (CA-1), suggests it may be involved
in the pathophysiology of depressive episodes in BD. Thus, BD pathophysiology may be
associated with early perturbations in lipid metabolism that are independent of mood
state, while CA-1 may be involved in the pathophysiology of depressive episodes. 相似文献
27.
Improvement in Tricuspid Annular Plane Systolic Excursion with Pulmonary Hypertension Therapy in Pediatric Patients
下载免费PDF全文
![点击此处可从《Echocardiography (Mount Kisco, N.Y.)》网站下载免费的PDF全文](/ch/ext_images/free.gif)
28.
29.
30.