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排序方式: 共有705条查询结果,搜索用时 31 毫秒
701.
Seungyoun Jung Naomi Allen Alan A. Arslan Laura Baglietto Aurelio Barricarte Louise A. Brinton Brian L. Egleston Roni T. Falk Renée T. Fortner Kathy J. Helzlsouer Yutang Gao Annika Idahl Rudolph Kaaks Vittorio Krogh Melissa A. Merritt Eva Lundin N. Charlotte Onland‐Moret Sabina Rinaldi Helena Schock Xiao‐Ou Shu Patrick M. Sluss Paul N. Staats Carlotta Sacerdote Ruth C. Travis Anne Tjønneland Antonia Trichopoulou Shelley S. Tworoger Kala Visvanathan Elisabete Weiderpass Anne Zeleniuch‐Jacquotte Joanne F. Dorgan 《International journal of cancer. Journal international du cancer》2018,142(2):262-270
Animal and experimental data suggest that anti‐Müllerian hormone (AMH) serves as a marker of ovarian reserve and inhibits the growth of ovarian tumors. However, few epidemiologic studies have examined the association between AMH and ovarian cancer risk. We conducted a nested case‐control study of 302 ovarian cancer cases and 336 matched controls from nine cohorts. Prediagnostic blood samples of premenopausal women were assayed for AMH using a picoAMH enzyme‐linked immunosorbent assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using multivariable‐adjusted conditional logistic regression. AMH concentration was not associated with overall ovarian cancer risk. The multivariable‐adjusted OR (95% CI), comparing the highest to the lowest quartile of AMH, was 0.99 (0.59–1.67) (Ptrend: 0.91). The association did not differ by age at blood draw or oral contraceptive use (all Pheterogeneity: ≥0.26). There also was no evidence for heterogeneity of risk for tumors defined by histologic developmental pathway, stage, and grade, and by age at diagnosis and time between blood draw and diagnosis (all Pheterogeneity: ≥0.39). In conclusion, this analysis of mostly late premenopausal women from nine cohorts does not support the hypothesized inverse association between prediagnostic circulating levels of AMH and risk of ovarian cancer. 相似文献
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Elizabeth Mairenn Garden Kala Kumaresan Allan Clark Carl Martin Philpott 《Clinical otolaryngology》2023,48(2):206-212
Background
The Olfactory Disorders Questionnaire (ODQ) is widely used for patients suffering from olfactory disorders to depict the impact on quality of life. The aim of this study was to scale and produce reference values for patients ODQ score according to Becks Depression Inventory (BDI) severity.Methods
In this prospective study, a cross-sectional anonymous survey was created, which combined EQ-5D-5L, BDI and ODQ. Correlation was calculated between the three questionnaires. Receiver operator characteristic curves were created to produce cut-off values for ODQ scores based on three BDI categories (mild, borderline clinical and moderate-to-severe depression).Results
Of the 578 who responded to the survey, 445 completed all sections and were included in the study. Majority were female (n = 327,73.5%), median age group 55–70 years (n = 193,43.4%). There was a strong correlation between BDI score and total ODQ score. There was a clear gradient in total ODQ score for each BDI classification; those with mild depression had the lowest mean ODQ score (101.8, range 39–168), those with moderate-to-severe depression had the highest (138.24, range 74–177). Due to overlapping of confidence intervals we were unable to grade the ODQ score.Conclusion
The study was unable to generate reference values for the ODQ due to lower numbers of patients with borderline clinical to extreme depression. However, we were able to appreciate the general trend, that the higher the ODQ score, the higher the risk of depression. These findings should guide clinical practice to ensure appropriate care and support is provided for those with olfactory dysfunction. 相似文献704.
705.