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??OBJECTIVE To study the impurity profile of cefradine dihydrate. METHODS The impurity peaks of cefradine dihydrate were identified using column-switching technique and LC-MS, and the origination of the impurities were investigated by the forced degradation study.RESULTS The impurity profile of cefradine dihydrate included fourteen impurities, nine of them were structure known impurities controlled by EP, two of them were newly identified impurities and three of them were structure unknown impurities.CONCLUSION The origination and influence factors of the impurities are investigated though the impurity profile study of cefradine dihydrate, and it can provide reference for the quality control of cefradine dihydrate.     

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??OBJECTIVE To study the influence of bioavailability of Epimedium flavonoids after processing by suet oil. METHODS Pharmacokinetics parameters of rats Epimedium flavonoids and icariin and baohuoside ?? was determining by the method of pharmacology effect and plasma concentration method. RESULTS The concentration of the Epimedium flavonoids, icariin and baohuoside ?? in micelles groups were higher than that of the active pharmaceutical ingredient(API). ??_max were increased by 77.94%, 38.99% and 49.90%; AUC_0-t increased by 95.19%, 37.76% and 43.49%; AUC_0-?? increased by 119.35%, 35.37% and 46.26% on Epimedium flavonoids, icariin and baohuoside ?? group. CONCLUSION Suet oil improved the bioavailability of Epimedium flavonoids and promoted its absorption.     

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??OBJECTIVE To study the effect of "cancel drug addition" policy in county public hospitals, and to provide reference for further improvement of relevant policies. METHODS This paper compares the data of medical expenses control, hospital income and expenditure, compensation and so on before and after the policy of "canceling the drug addition" of a county public hospital to study the actual effect of policy implementation. RESULTS The proportion of drugs after the implementation of the decline, from the policy before the implementation of 43.6% to the policy objectives (30%). The total cost of drug growth rate is lower than before the implementation of the policy, the slowdown in growth; outpatient average medical expenses, inpatient per capita reduction in drug costs, the difference was statistically significant. The average cost of medical care was increasing, and the growth rate dropped first and then rose, which was close to the level before the implementation of the policy. At the same time, the income structure of the county-level hospitals tends to be reasonable, but the balance of payments has dropped significantly. The increase in hospital investment and adjust the price of medical services increased hospital income is not enough to make up for the "cancellation of drug additions" brought about by the loss. CONCLUSION "Cancellation of drug addition" policy in the county-level public hospitals since the implementation of the control of medical expenses have a certain role in the control of drug costs growth effect is obvious. Patient medical expenses are falling. In order to consolidate the effectiveness, but also the establishment of multi-share long-term compensation mechanism, while paying attention to the increase in medical staff income.     

基于数据的证候规范的信息研究

以讨论证候规范信息研究中数据客观化解决的思路与方法为主题,通过对基于数据的意义、数据客观化的解决方案、证候规范研究对学习技术的需求等问题的讨论,强调证候规范研究数据客观性的重要,界定中医数据客观性的意义,提出基于数据的信息研究方案,论证了采用支持向量机方法(Supporter Vector Machine,简记SVM)的优势。认为“有效”和“普遍”是中医学数据客观性的主要依据,数据的客观化是中医证候规范研究的重要前提。     

β-联蛋白在恶性胸膜间皮瘤组织的表达及其对肿瘤的抑制作用

目的：探讨β-联蛋白在恶性胸膜间皮瘤组织的表达及其对肿瘤抑制作用。方法：应用AnnexinV和TUNEL法分别检测转染野生型β-联蛋白（β-CAT-V5-FP）和突变型β-联蛋白 （β-CAT-S37C-V5-FP）诱导恶性胸膜间皮瘤NCI-H28细胞凋亡;采用体外细胞培养法,研究β-联蛋白基因对肿瘤的抑制作用。结果：转染野生型β-联蛋白和突变型β-联蛋白的细胞凋亡率与转染空白载体组比较均有明显的增高。转染羧基端缺失的β-联蛋白基因也可导致细胞凋亡,但与转染野生型β-联蛋白（β-CAT-V5-FP）和突变型β-联蛋白（β-CAT-S37C-V5-FP）的细胞相比明显减少。结论：β-联蛋白基因在非上皮性肿瘤——恶性胸膜间皮瘤中也可诱导细胞凋亡。     

康复疗法与口服替扎尼定联合治疗脑卒中偏瘫肌痉挛疗效观察

目的 观察康复疗法联合口服替扎尼定(Tizandine)治疗脑卒中后偏瘫肌痉挛的效果.方法 将46例脑卒中所致偏瘫患者随机分为治疗组和对照组.其中对照组23例采用综合康复治疗方法,包括抗痉挛体位摆放、被动关节活动、持续牵张运动、手法按摩、肢体空气压力治疗、站立训练、健康教育等;治疗组23例,在康复治疗的基础上采用口服替扎尼定治疗.采用修订的Ashworth分级法(MAS)和改良的巴氏指数评定法(MBI)对两组患者治疗前后肌张力、日常生活活动能力(ADL)进行评定.结果 经过治疗,两组患者肌张力较治疗前均有明显降低(P＜0.05),生活自理能力较治疗前有明显提高(P＜0.01),且治疗组疗效明显优于对照组(P＜0.05).结论 替扎尼定联合康复疗法对脑卒中所致偏瘫肌痉挛有显著的改善作用,同时可提高患者生活自理能力,值得推广.     

上海部分地区健康人群血清促甲状腺素受体抗体参考区间的建立

目的 建立上海部分地区健康人群血清促甲状腺素受体抗体(thyrotrophin receptor antibody,TRAb)的参考区间.方法 选择上海部分地区的健康人群1468名.采用电化学发光法检测促甲状腺素受体抗体水平,SPSS19.0软件对检测结果进行分析,获得上下限,中位数,百分位数.结果 1468名健康人血清促甲状腺素受体抗体呈偏态分布,采用百分位数法(95％分布区间)确定参考区间.男性与女性各年龄组血清促甲状腺素受体抗体之间水平差异均无统计学意义(P＞0.05),可建立统一参考区间(0.30 ～0.82IU/L).结论 建立适合本地区健康人群的促甲状腺素受体抗体参考区间.