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201.
Joanne SM Kim Brendan N Lilley Chao Zhang Kevan M Shokat Joshua R Sanes Mei Zhen 《Neural development》2008,3(1):1-14
Background
β-Amyloid precursor protein (APP) has been reported to play a role in the outgrowth of neurites from cultured neurons. Both cell-surface APP and its soluble, ectodomain cleavage product (APPs-α) have been implicated in regulating the length and branching of neurites in a variety of assays, but the mechanism by which APP performs this function is not understood.Results
Here, we report that APP is required for proper neurite outgrowth in a cell autonomous manner, both in vitro and in vivo. Neurons that lack APP undergo elongation of their longest neurite. Deletion of APLP1 or APLP2, homologues of APP, likewise stimulates neurite lengthening. Intriguingly, wild-type neurons exposed to APPs-α, the principal cleavage product of APP, also undergo neurite elongation. However, APPs-α is unable to stimulate neurite elongation in the absence of cellular APP expression. The outgrowth-enhancing effects of both APPs-α and the deletion of APP are inhibited by blocking antibodies to Integrin β1 (Itgβ1). Moreover, full length APP interacts biochemically with Itgβ1, and APPs-α can interfere with this binding.Conclusion
Our findings indicate that APPs-α regulates the function of APP in neurite outgrowth via the novel mechanism of competing with the binding of APP to Itgβ1. 相似文献202.
Kelz RR Freeman KM Hosokawa PW Asch DA Spitz FR Moskowitz M Henderson WG Mitchell ME Itani KM 《Annals of surgery》2008,247(3):544-552
OBJECTIVE: To examine the association between surgical start time and morbidity and mortality for nonemergent procedures. SUMMARY BACKGROUND DATA: Patients require medical services 24 hours a day. Several studies have demonstrated a difference in outcomes over the course of the day for anesthetic adverse events, death in the ICU, and dialysis care. The relationship between operation start time and patient outcomes is yet undefined. METHODS: We performed a retrospective cohort study of 144,740 nonemergent general and vascular surgical procedures performed within the VA Medical System 2000-2004 and entered into the National Surgical Quality Improvement Program Database. Operation start time was the independent variable of interest. Logistic regression was used to adjust for patient and procedural characteristics and to determine the association between start time and, in 2 independent models, mortality and morbidity. RESULTS: Unadjusted later start time was significantly associated with higher surgical morbidity and mortality. After adjustment for patient and procedure characteristics, mortality was not significantly associated with start time. However, after appropriate adjustment, operations starting between 4 pm and 6 pm were associated with an elevated risk of morbidity (OR = 1.25, P < or = 0.005) over those starting between 7 am and 4 pm as were operations starting between 6 pm and 11 pm (OR = 1.60, P < or = 0.005). CONCLUSIONS: When considering a nonemergent procedure, surgeons must bear in mind that cases that start after routine "business" hours within the VA System may face an elevated risk of complications that warrants further evaluation. 相似文献
203.
Bahadir Simsek MD Jaikirshan Khatri MD Laura Young MD Spyridon Kostantinis MD Judit Karacsonyi MD PhD Athanasios Rempakos MD Khaldoon Alaswad MD Farouc A. Jaffer MD PhD Darshan Doshi MD Sevket Gorgulu MD Omer Goktekin MD Jimmy Kerrigan MD Elias V. Haddad MD Stephane Rinfret MD SM Wissam A. Jaber MD William Nicholson MD Oleg Krestyaninov MD Dimitrii Khelimskii MD James W. Choi MD Taral N. Patel MD Brian K. Jefferson MD Steven M. Bradley MD Sunil V. Rao MD Bavana V. Rangan BDS MPH Salman S. Allana MD Yader Sandoval MD M. Nicholas Burke MD Emmanouil S. Brilakis MD PhD Paul B. Poommipanit MD the PROGRESS-CTO investigators 《Catheterization and cardiovascular interventions》2023,101(6):1028-1035
204.
Mauro Carlino MD Barry F. Uretsky MD Lorenzo Azzalini MD PhD MSc Angelo Nascimbene MD Emmanouil S. Brilakis MD PhD Antonio Colombo MD Sunao Nakamura MD Cosmo Godino MD Alexandre Avran MD Stéphane Rinfret MD SM Benjamin Faurie MD 《Catheterization and cardiovascular interventions》2023,102(4):577-584
Introduction
Antegrade dissection and re-entry (ADR) is an integral part of the hybrid algorithm, which has allowed for improved outcomes in chronic total occlusion (CTO) coronary intervention (PCI).Methods
A new ADR method, Subintimal Antegrade FEnestration and Re-entry (SAFER), is described. The results of a first-in-man series are presented.Results
SAFER was performed on seven consecutive patients with angiographic and clinical success in all patients.Conclusions
This first-in-man study has shown that the SAFER technique is feasible and effective with the possibility of improving the antegrade PCI CTO success rate. 相似文献205.
206.
207.
Evan L. Thacker SM Honglei Chen MD PhD Alpa V. Patel PhD Marjorie L. McCullough ScD Eugenia E. Calle PhD Michael J. Thun MD Michael A. Schwarzschild MD PhD Alberto Ascherio MD DrPH 《Movement disorders》2008,23(1):69-74
The purpose of this study was to investigate associations between recreational physical activity and Parkinson's disease (PD) risk. We prospectively followed 143,325 participants in the Cancer Prevention Study II Nutrition Cohort from 1992 to 2001 (mean age at baseline = 63). Recreational physical activity was estimated at baseline from the reported number of hours per week on average spent performing light intensity activities (walking, dancing) and moderate to vigorous intensity activities (jogging/running, lap swimming, tennis/racquetball, bicycling/stationary bike, aerobics/calisthenics). Incident cases of PD (n = 413) were confirmed by treating physicians and medical record review. Relative risks (RR) were estimated using proportional hazards models, adjusting for age, gender, smoking, and other risk factors. Risk of PD declined in the highest categories of baseline recreational activity. The RR comparing the highest category of total recreational activity (men ≥ 23 metabolic equivalent task‐hours/week [MET‐h/wk], women ≥ 18.5 MET‐h/wk) to no activity was 0.8 (95% CI: 0.6, 1.2; P trend = 0.07). When light activity and moderate to vigorous activity were examined separately, only the latter was found to be associated with PD risk. The RR comparing the highest category of moderate to vigorous activity (men ≥ 16 MET‐h/wk, women ≥ 11.5 MET‐h/wk) to the lowest (0 MET‐h/wk) was 0.6 (95% CI: 0.4, 1.0; P trend = 0.02). These results did not differ significantly by gender. The results were similar when we excluded cases with symptom onset in the first 4 years of follow‐up. Our results may be explained either by a reduction in PD risk through moderate to vigorous activity, or by decreased baseline recreational activity due to preclinical PD. © 2007 Movement Disorder Society 相似文献
208.
Mouhsin M. Shafi MD PhD Emiliano Santarnecchi PhD Tamara G. Fong MD PhD Richard N. Jones ScD Edward R. Marcantonio MD SM Alvaro Pascual‐Leone MD PhD Sharon K. Inouye MD MPH 《Journal of the American Geriatrics Society》2017,65(6):1114-1118
Delirium is a common problem associated with substantial morbidity and increased mortality. However, the brain dysfunction that leads some individuals to develop delirium in response to stressors is unclear. In this article, we briefly review the neurophysiologic literature characterizing the changes in brain function that occur in delirium, and in other cognitive disorders such as Alzheimer's disease. Based on this literature, we propose a conceptual model for delirium. We propose that delirium results from a breakdown of brain function in individuals with impairments in brain connectivity and brain plasticity exposed to a stressor. The validity of this conceptual model can be tested using Transcranial Magnetic Stimulation in combination with Electroencephalography, and, if accurate, could lead to the development of biomarkers for delirium risk in individual patients. This model could also be used to guide interventions to decrease the risk of cerebral dysfunction in patients preoperatively, and facilitate recovery in patients during or after an episode of delirium. 相似文献
209.
Simone SM Ho Winnie WM Yu Terence T Lao Daniel HK Chow Joanne WY Chung Yi Li 《Journal of clinical nursing》2009,18(11):1523-1532
Aims. This article aims to review the literature published to date on the types, current use, the biomechanical effects and adverse effects of maternity support belts for low back pain during pregnancy, to identify future research directions. Background. Lumbar/pelvic support belts are frequently recommended for the prevention and treatment of low back pain during pregnancy. Design. Systematic review. Methods. MEDLINE, CINAHL, the Cochrane Library and patents databases were electronically searched. Results. Maternity support belts belong to one of the four main types of maternity support garments, which are widely commercially‐available. Current research showed limited evidence in support of the commercial maternity products regarding the effectiveness in the prevention and/or treatment of low back pain during pregnancy, other than that from the manufacturers. However, potential stabilisation effect of maternity support belt was demonstrated in some studies. Adverse effects reported include increased pain, fetal heart rate changes, skin irritation and discomfort. Conclusions. There is insufficient scientific evidence to conclude that wearing maternity support belts reduces pregnancy‐related low back pain and/or pelvic girdle pain. Future research directions in the area of biomechanics and physiology are recommended. Relevance to clinical practice. This review provides comprehensive understanding of the effectiveness of maternity support belts for the relief of low back pain during pregnancy which will facilitate healthcare professionals in providing evidence‐based advice to their patients. 相似文献
210.