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排序方式: 共有418条查询结果,搜索用时 15 毫秒
41.
42.
世界胃肠病学组织(WGO-OMGE)临床指南——发展中国家幽门螺杆菌感染 总被引:16,自引:1,他引:16
Hunt RH Xiao SD Megraud F Leon-Barua R Bazzoli F Van der Merwe S vaz Coelho LG Fock KM Fedail S Cohen H Malfertheiner P Vakil N Hamid S Goh KL Wong BC Krabshuis JH 杜颖 丛衍群 戴宁 《胃肠病学》2007,12(1):40-52
我非常高兴向大家推荐这份发展中国家幽门螺杆菌(H.priori)临床指南。该指南的编译是由数位在该领域具有丰富临床经验的世界知名专家共同完成的。 相似文献
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44.
美国白人与中国人原发性结直肠癌病理特点对照 总被引:4,自引:0,他引:4
目的 比较研究美国白人与中国患者原发性结直肠癌 (CRC)的病理学特征。方法 回顾性分析 1990~ 2 0 0 0年美国克里夫兰佛罗里达临床中心结直肠外科 6 90例和中国第一军医大学南方医院普外科 870例连续完整的CRC患者资料。结果 美国白人与中国患者比较 :36 .3%比 2 6 .0 %的肿瘤位于近侧 (右侧 )结肠 (P <0 .0 0 1) ,6 3.7%比 74 .0 %位于远侧 (左侧 )结肠 (P <0 .0 0 1) ;中位年龄 72比5 4岁 (P <0 .0 0 1) ;腺癌 84 .3%比 85 .3% ,黏液腺癌 13.6 %比 11.4 % ,印戒细胞癌 1.5 %比 2 .7% ,腺鳞癌 0 .6 %比 0 .6 % (P >0 .0 5 ) ;高分化癌 16 .7%比 4 0 .2 % ,中分化 6 1.9%比 4 8.5 % ,低分化 2 1.4 %比11.3% (P <0 .0 0 1) ,近侧结肠癌中低分化比例在两种族患者中均较高 ;TNM分期 ,0期 5 .4 %比 1.3%(P <0 .0 0 1) ,Ⅰ期 34.8%比 18.9% (P <0 .0 0 1) ,Ⅱ期 2 9.9%比 33.2 % (P >0 .0 5 ) ,Ⅲ期 2 0 .3%比2 2 .8% (P >0 .0 5 ) ,Ⅳ期 9.6 %比 17.0 % (P <0 .0 0 1)。进展期癌更常见于近侧结肠和中国患者。结论 美国白人易患近侧结肠癌 ,中国患者远侧结直肠癌更常见 ,进展期比例高 ,年龄明显小。低分化和进展期癌更常见于近侧结肠。 相似文献
45.
Molecular cloning, chromosomal location, and tissue-specific expression of the murine cathepsin G gene 总被引:5,自引:1,他引:5
Heusel JW; Scarpati EM; Jenkins NA; Gilbert DJ; Copeland NG; Shapiro SD; Ley TJ 《Blood》1993,81(6):1614-1623
We previously have characterized a cluster of genes encoding cathepsin G (CG) and two other CG-like hematopoietic serine proteases, CGL-1 and CGL-2, on human chromosome 14. In this report, we clone and characterize a novel, related murine hematopoietic serine protease gene using human CG (hCG) cDNA as the probe. This murine gene spans approximately 2.5 kb of genomic DNA, is organized into five exons and four introns, and bears a high degree of homology to hCG at both nucleic acid (73%) and deduced amino acid (66%) levels. The predicted cDNA contains an open reading frame of 783 nucleotides that encodes a nascent protein of 261 amino acids. Processing of a putative signal (pre) peptide of 18 residues and an activation (pro) dipeptide would generate a mature enzyme of approximately 27 Kd that has an estimated pI of 12.0. Conserved residues at His44, Asp88, and Ser181 form the characteristic catalytic triad of the serine protease superfamily. The gene is tightly linked to the CTLA-1 locus on murine chromosome 14, where the serine protease genes mCCP1-4 are clustered. Expression of this gene is detected only in the bone marrow and is restricted to a small population of early myeloid cells. These findings are consistent with the identification of the gene encoding murine CG. 相似文献
46.
Characterization of CD33 as a new member of the sialoadhesin family of cellular interaction molecules 总被引:14,自引:6,他引:14
CD33 is a member of the Ig superfamily that is restricted to cells of the myelomonocytic lineage but whose functions and binding properties are unknown. It shares sequence similarity with sialoadhesin, CD22, and the myelin-associated glycoprotein, which constitute the Sialoadhesin family of sialic acid-dependent cell adhesion molecules. In the present study, we show that CD33 is a fourth member of this family. As a model for sialic acid-dependent binding, human erythrocytes were derivatized with N-acetylneuraminic acid (NeuAc) in different linkages. A recombinant soluble form of CD33, Fc-CD33, bound red blood cells with a specificity similar to that of sialoadhesin, preferring NeuAc alpha 2,3Gal in N- and O-glycans over NeuAc alpha 2,6Gal in N-glycans. Fc- CD33 also bound selectively to the myeloid cell lines HL-60 and U937. However, CD33 was unable to mediate cell binding after transient expression in COS cells, despite high levels of surface expression. Pretreatment of the CD33-transfected cells with sialidase rendered them capable of mediating sialic acid-dependent binding. These results show that CD33 can function as a sialic acid-dependent cell adhesion molecule and that binding can be modulated by endogenous sialoglycoconjugates when CD33 is expressed in a plasma membrane. 相似文献
47.
Magnetization transfer contrast: MR imaging of the knee 总被引:1,自引:0,他引:1
48.
49.
Renal localization of gallium-67 citrate 总被引:1,自引:0,他引:1
50.
Effect of parental age on fertilization and pregnancy characteristics in couples treated by intracytoplasmic sperm injection 总被引:11,自引:5,他引:6
Spandorfer SD; Avrech OM; Colombero LT; Palermo GD; Rosenwaks Z 《Human reproduction (Oxford, England)》1998,13(2):334-338
The purpose of this study was to investigate any influence of maternal
and/or paternal age on gamete characteristics and pregnancy outcomes in
intracytoplasmic sperm injection (ICSI) cycles. In all, 821 consecutive
ICSI cases were analysed retrospectively. While a significant linear
decline in semen volume was detected, no significant differences in the
concentration, motility or morphology of the spermatozoa were found with
paternal ageing. A significant decline in the number of oocytes retrieved
and the number of mature oocytes obtained was found with advancing maternal
age. An increase in the occurrence of digyny was noted with parental
ageing, while no difference in single or bipronuclear fertilization was
found. Older women had a decreased incidence of single pronucleus formation
and an increase in digyny, but no significant difference in the percentage
of oocytes that underwent two-pronuclear fertilization was detected with
regard to maternal ageing. Pregnancy outcomes were not influenced by the
age of the male partner, while a strong negative correlation was found with
maternal ageing. To better analyse male partner ageing as a factor
affecting pregnancy outcome, we analysed a subgroup of patients with a
female partner aged <35 years who underwent ICSI. No paternal influence
on ICSI pregnancy outcome was found in this subgroup of patients. We
conclude that the influence on pregnancy outcome after ICSI is related
mostly to maternal and not paternal age.
相似文献