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21.
Clinical and biological effects of treatment with amifostine in myelodysplastic syndromes 总被引:5,自引:0,他引:5
Invernizzi R Pecci A Travaglino E Gobbi PG Malabarba L Ramajoli I Ascari E 《British journal of haematology》2002,118(1):246-250
We treated six patients with primary myelodysplastic syndrome (MDS) with amifostine (200 mg/m(2) i.v./three times a week for three consecutive weeks). Neutrophil counts were more frequently increased than platelet and reticulocyte counts, but no reduction of the transfusion requirement was observed. Significant reduction of the marrow blasts was observed in one case of refractory anaemia with excess of blasts. In vitro stimulation of haematopoiesis was observed in five cases. The apoptotic rate of marrow cells was significantly diminished even after the first course. Our findings show fairly good clinical and biological response to amifostine in MDS. 相似文献
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Thiana Santiago Nascimento Esther Faria Braga Giselle Cristina Casaes Gomes William Romo Batista Andr Luís Mazzei Albert Rosangela Sabbatini Capella Lopes Claudio Cerqueira Lopes 《RSC advances》2020,10(2):1050
A chemoselective route for the synthesis of 1-O-alkylglycerols chimyl (1), batyl (2), and selachyl (3) is reported. These compounds can be naturally isolated from shark liver oil and the skin of animals such as stingrays and chimeras and exhibit potential anti-fouling activity. The synthetic approach developed in this work included two distinct methods of preparation. The first was based on solvent-free reactions catalyzed by onium quaternary salts (N and P) and ionic liquids; the second methodology was based on a series of one-pot reactions.A chemoselective route for the synthesis of 1-O-alkylglycerols chimyl (1), batyl (2), and selachyl (3) is reported. 相似文献
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Fumiaki Oka Jeong Hyun Lee Izumi Yuzawa Mei Li Daniel von Bornstaedt Katharina Eikermann-Haerter Tao Qin David Y. Chung Homa Sadeghian Jessica L. Seidel Takahiko Imai Doga Vuralli Rosangela M. Platt Mark T. Nelson Anne Joutel Sava Sakadzic Cenk Ayata 《The Journal of clinical investigation》2022,132(8)
Cerebral autosomal dominant arteriopathy, subcortical infarcts, and leukoencephalopathy (CADASIL) is the most common monogenic form of small vessel disease characterized by migraine with aura, leukoaraiosis, strokes, and dementia. CADASIL mutations cause cerebrovascular dysfunction in both animal models and humans. Here, we showed that 2 different human CADASIL mutations (Notch3 R90C or R169C) worsen ischemic stroke outcomes in transgenic mice; this was explained by the higher blood flow threshold to maintain tissue viability compared with that in wild type (WT) mice. Both mutants developed larger infarcts and worse neurological deficits compared with WT mice, regardless of age or sex after filament middle cerebral artery occlusion. However, full-field laser speckle flowmetry during distal middle cerebral artery occlusion showed comparable perfusion deficits in mutants and their respective WT controls. Circle of Willis anatomy and pial collateralization also did not differ among the genotypes. In contrast, mutants had a higher cerebral blood flow threshold, below which infarction ensued, suggesting increased sensitivity of brain tissue to ischemia. Electrophysiological recordings revealed a 1.5- to 2-fold higher frequency of peri-infarct spreading depolarizations in CADASIL mutants. Higher extracellular K+ elevations during spreading depolarizations in the mutants implicated a defect in extracellular K+ clearance. Altogether, these data reveal a mechanism of enhanced vulnerability to ischemic injury linked to abnormal extracellular ion homeostasis and susceptibility to ischemic depolarizations in CADASIL. 相似文献
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Dura to spinal cord distance at different vertebral levels in children and its implications on epidural analgesia: A retrospective MRI‐based study 下载免费PDF全文
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A survey was carried out in a pharmaceutical industry, in order to know the exposure to environmental tobacco smoke (ETS) in the workplace, and attitudes of workers toward workplace smoking restrictions and bans. In the three plants of the industry (Bergamo, Milan, Reggello-Florence) workers were exposed to ETS in every workplace areas, except for the production area, even if there were no-smoking warning notices in the plants. Non-smokers were more favorable than smokers about the introduction of workplace restrictions on smoking. In order to decrease exposure to ETS, it would be desirable to develop workplace smoking restrictions or bans, effective and low-cost interventions. 相似文献