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排序方式: 共有143条查询结果,搜索用时 15 毫秒
21.
Marloes van Gorp Mala M. H. Joosten Anne Maas Babet L. Drenth Alied van der Aa–van Delden Leontien C. M. Kremer Eline van Dulmen-den Broeder Wim J. E. Tissing Jacqueline J. Loonen Helena J. H. van der Pal Andrica C. H. de Vries Marry M. van den Heuvel-Eibrink Cécile Ronckers Dorine Bresters Marloes Louwerens Sebastian J. C. C. M. Neggers Margriet van der Heiden-van der Loo Heleen Maurice-Stam Martha A. Grootenhuis Dutch LATER study group 《Psycho-oncology》2023,32(2):283-294
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This paper summarizes current knowledge on ionizing radiation-associated breast cancer in the context of established breast cancer risk factors, the radiation dose-response relationship, and modifiers of dose response, taking into account epidemiological studies and animal experiments. Available epidemiological data support a linear dose-response relationship down to doses as low as about 100 mSv. However, the magnitude of risk per unit dose depends strongly on when radiation exposure occurs: exposure before the age of 20 years carries the greatest risk. Other characteristics that may influence the magnitude of dose-specific risk include attained age (that is, age at observation for risk), age at first full-term birth, parity, and possibly a history of benign breast disease, exposure to radiation while pregnant, and genetic factors. 相似文献
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Marloes van Gorp PhD Loes M. E. van Erp MSc Anne Maas MSc Leontien C. M. Kremer MD PhD Eline van Dulmen-den Broeder PhD Wim J. E. Tissing MD PhD Jacqueline J. Loonen MD PhD Helena J. H. van der Pal MD PhD Andrica C. H. de Vries MD PhD Marry M. van den Heuvel-Eibrink MD PhD Cécile M. Ronckers PhD Dorine Bresters MD PhD Marloes Louwerens MD Margriet van der Heiden-van der Loo PhD Gea A. Huizinga PhD Heleen Maurice-Stam PhD Martha A. Grootenhuis PhD for the Dutch LATER Study Group 《Cancer》2022,128(5):1074-1084
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Panagiotis Tsibouris Mark T Hendrickse Panagiota Mavrogianni Peter ET Isaacs 《World journal of gastrointestinal pharmacology and therapeutics》2014,5(3):183-190
AIM:To define the significance of ischemic heart disease(IHD)(stable angina to infarction) co-existance in Barrett esophagus(BE) patients and patients with esophageal adenocarcinoma(AdE).METHODS: All BE/AdE patients in Blackpool-Wyre-Fylde area and Trikala prefecture identified from medical records. Patient clinical details were obtained from hospital and General Practitioner records. Additional information was gathered from validated questionnaire.RESULTS: Forty(33%) AdE and 83(19%) BE patients had IHD(P = 0.002). Eighteen(15%) AdE and 34(8%) BE patients had suffered a myocardial infarction(P = 0.03). Three(3%) AdE and 7(2%) BE patients had severe heart failure(P = 0.82). Thirty-nine(47%) BE with IHD and 8(20%) AdE patients with IHD consumed aspirin daily(P = 0.004). Seventh-seven(93%) BE patients with IHD and 36(90%) AdE patients with IHD were on statins(P = 0.86). Logistic regression analysis: AdE was more frequent in the elderly,with long termreflux,long BE and concurrent IHD(odds ratio: 2.086,P = 0.001) not consuming statins. Eighteen(22%) BE patients with IHD [16(84%) with myocardial infarction] vs 33(10%) without IHD died from non-neoplastic causes within 24 mo from BE diagnosis(P = 0.005). CONCLUSION: IHD is more prevalent in AdE than BE patients. Increased prevalence of AdE is related with the presence of myocardial infarction but not severe heart failure,possibly because patients with BE and se-vere IHD have low life expectancy. 相似文献
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Irma W.E.M. van Dijk Mathilde C. Cardous-Ubbink Helena J.H. van der Pal Richard C. Heinen Flora E. van Leeuwen Foppe Oldenburger Rob M. van Os Cécile M. Ronckers Antoinette Y.N. Schouten–van Meeteren Huib N. Caron Caro C.E. Koning Leontien C.M. Kremer 《International journal of radiation oncology, biology, physics》2013
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Cost–utility analysis of an advanced pressure ulcer management protocol followed by trained wound,ostomy, and continence nurses 下载免费PDF全文
Toshiko Kaitani PhD RN Gojiro Nakagami PhD RN Shinji Iizaka PhD RN Takashi Fukuda PhD Makoto Oe PhD RN Ataru Igarashi PhD Taketoshi Mori PhD Yukie Takemura PhD RN CAN Yuko Mizokami MA RN ET Junko Sugama PhD RN Hiromi Sanada PhD RN WOCN 《Wound repair and regeneration》2015,23(6):915-921
The high prevalence of severe pressure ulcers (PUs) is an important issue that requires to be highlighted in Japan. In a previous study, we devised an advanced PU management protocol to enable early detection of and intervention for deep tissue injury and critical colonization. This protocol was effective for preventing more severe PUs. The present study aimed to compare the cost‐effectiveness of the care provided using an advanced PU management protocol, from a medical provider's perspective, implemented by trained wound, ostomy, and continence nurses (WOCNs), with that of conventional care provided by a control group of WOCNs. A Markov model was constructed for a 1‐year time horizon to determine the incremental cost‐effectiveness ratio of advanced PU management compared with conventional care. The number of quality‐adjusted life‐years gained, and the cost in Japanese yen (¥) ($US1 = ¥120; 2015) was used as the outcome. Model inputs for clinical probabilities and related costs were based on our previous clinical trial results. Univariate sensitivity analyses were performed. Furthermore, a Bayesian multivariate probability sensitivity analysis was performed using Monte Carlo simulations with advanced PU management. Two different models were created for initial cohort distribution. For both models, the expected effectiveness for the intervention group using advanced PU management techniques was high, with a low expected cost value. The sensitivity analyses suggested that the results were robust. Intervention by WOCNs using advanced PU management techniques was more effective and cost‐effective than conventional care. 相似文献
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Activated human natural killer (NK) cells undergo rapid apoptotic cell death after ligand binding to the Fc receptor (CD16). We examined whether human NK cells die after engagement in cytolytic functions. Peripheral blood NK cells, with and without prior activation in vitro with interleukin-2 (IL-2), were tested for the occurrence of cell death after incubation with K562, the prototype NK-sensitive target cell. A proportion (15.2%) of NK cells that were stimulated for 3 days with IL- 2 and then incubated for 4 hours with K562 cells showed rapid cell death, but NK cells not stimulated with IL-2 did not. This cell death was found to involve nuclear condensation and fragmentation and DNA cleavage, all of which are characteristic of apoptosis. These data indicate that a proportion of activated human NK cells undergo apoptosis as they engage in target cell lysis. Target-induced NK cell death may represent an important mechanism for regulation of inflammatory processes involving NK cells. 相似文献