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91.
92.
Constantin Schizas No?l Foko’o Maurice Matter Sebastien Romy Everard Munting 《European spine journal》2009,18(Z2):228-231
Lymphocoele is a rare and little known complication with only a handful of reports available. We report two cases of lymphocoele
after anterior lumbar surgery that have occurred in two different centres and discuss diagnosis and management options. The
first case is that of a 53-year-old male patient undergoing two level anterior lumbar interbody fusion (ALIF) for disabling
back pain due to disc degeneration in the context of an old spondylodiscitis. He developed a large fluid mass postoperatively.
Fluid levels of creatinin were low and intravenous urography ruled out a urinoma suggesting the diagnosis of a lymphocoele.
Following two unsuccessful drainage attempts he underwent a laparoscopic marsupialization. The second case was that of a 32-year-old
female patient developing a large fluid mass following a L5 corpectomy for a burst fracture. She was treated successfully
with insertion of a vacuum drain during 7 days. Lymphocoele is a rare complication but should be suspected if fluid collects
postoperatively following anterior lumbar spine procedures. Chemical analysis of the fluid can help in diagnosis. Modern treatment
consists of laparoscopic marsupialization. Lymph vessel anatomy should be borne in mind while exposing the anterior lumbar
spine. 相似文献
93.
Peter Walla Herwig Imhof Wilfried Lang 《Journal of neural transmission (Vienna, Austria : 1996)》2009,116(10):1227-1236
We measured brain activities with a whole head magnetoencephalograph (MEG) to investigate the influence of a background odor
on alphabetical encoding of words in 20 healthy volunteers (10 females). Odor stimulation and control air stimulation were
both accomplished with a computer-controlled olfactometer by providing permanent stimulation conditions. Behavioral data revealed
significantly prolonged reaction times in men under the influence of phenylethyl alcohol (PEA) compared to the control condition.
Women did not show a change in reaction time during stimulation with PEA. A comparison of men and women revealed significantly
shorter reaction times in women for both the odor conditions, as well as for the control condition. Analysis of performance
accuracy showed no significant differences between the odor and the control condition within and across gender. Analysis of
grand averaged, event-related fields and localization of the underlying equivalent current dipoles revealed higher dipole
strength in the odor, compared to the control condition in the right hemisphere, over the temporo-parietal brain areas, in
the time range between 200 and 500 ms after word-onset only in male subjects. Within this time range, the gender-specific
effect is interpreted to reflect odor-related modulation of word processing. The findings suggest gender-specific processing
strategies in the present task with implications for differences in hemispheric laterality. 相似文献
94.
This study sought to both assist in the selection of flaps for ischial pressure wound reconstruction and evaluate the overall complication rates associated with reconstruction. A retrospective medical record review was conducted for 78 patients following the surgical reconstruction of an ischial pressure sore. Records were reviewed for demographics, location of sores, methods of reconstruction and flap selection, as well as any complications and recurrences. A total of 72 wounds were reconstructed with an average of 1·4 flaps used per wound. An ischial flap complication rate of 16% was observed in flap follow‐up, with a recurrence rate of 7% recorded. The vast majority of complications went on to heal with 15% of patients requiring a second reconstruction. Our relatively large sample of ischial flaps allowed for a close comparison with previously published work. Both flap selection and site of reconstruction significantly affected the success rates for pressure sore coverage. The overall complication rates by flap and reconstructive site in this review are lower than previously published reports. Our experience with ischial reconstruction was extensive enough to suggest a posterior medial thigh fasciocutaneous flap combined with a biceps femoris muscle flap as a first choice in ischial pressure wound reconstruction. 相似文献
95.
Cohen M Bachmatov L Ben-Ari Z Rotman Y Tur-Kaspa R Zemel R 《Digestive diseases and sciences》2007,52(9):2427-2432
The hepatitis C virus (HCV) F protein is a recently described, frameshift product of HCV core encoding sequence with unknown
biological function. In this study we sought to characterize the prevalence of specific anti-F antibodies in patients with
chronic HCV infection and to analyze the anti-F antibody profile before, during, and after antiviral treatment in order to
gain a better understanding of the role of F protein in HCV pathogenesis.
Serum samples were collected from 44 patients with chronic HCV infection and from 19 healthy controls. Consecutive samples
from 27 patients taken before, during, and after treatment with antiviral therapy. The F and the core proteins were cloned
from the HCV genome. The recombinant proteins were expressed in Escherichia coli and affinity purified. A sensitive and specific enzyme-linked immunosorbent assay was developed to assess the prevalence
of anti-F antibodies. Eighty-nine percent of chronic HCV patients had evidence of anti-F antibodies, and 95% of them had anti-core
antibodies. No correlation of anti-F antibodies was found with response to treatment, genotype, or seroconversion. We conclude
that the F protein elicits specific antibodies in most individuals chronically infected with HCV with no correlation with
response to treatment. Our results confirm the expression of F protein during natural HCV infection. 相似文献
96.
The extracellular calcium-sensing receptor (CaR) senses small fluctuations of the extracellular calcium (Ca(2+)(e)) concentration and translates them into potent changes in parathyroid hormone secretion. Dissecting the regulatory mechanisms of CaR-mediated signal transduction may provide insights into the physiology of the receptor and identify new molecules as potential drug targets for the treatment of osteoporosis and/or hyperparathyroidism. CaR can be phosphorylated by protein kinase C (PKC) and G protein-coupled receptor kinases (GRKs), and has been shown to bind to beta-arrestins, potentially contributing to desensitization of CaR, although the mechanisms by which CaR-mediated signal transduction is terminated are not known. We used a PKC phosphorylation site-deficient CaR, GRK and beta-arrestin overexpression or down-regulation to delineate CaR-mediated desensitization. Fluorescence-activated cell sorting was used to determine whether receptor internalization contributed to desensitization. Overexpression of GRK 2 or 3 reduced Ca(2+)(e)-dependent inositol phosphate accumulation by more than 70%, whereas a GRK 2 mutant deficient in G alpha(q) binding (D110A) was without major effect. Overexpression of GRK 4-6 did not reduce Ca(2+)(e)-dependent inositol phosphate accumulation. Overexpression of beta-arrestin 1 or 2 revealed a modest inhibitory effect on Ca(2+)(e)-dependent inositol phosphate production (20-30%), which was not observed for the PKC phosphorylation site-deficient CaR. Agonist-dependent receptor internalization (10-15%) did not account for the described effects. Thus, we conclude that PKC phosphorylation of CaR contributes to beta-arrestin-dependent desensitization of CaR coupling to G proteins. In contrast, GRK 2 predominantly interferes with G protein-mediated inositol-1,4,5-trisphosphate formation by binding to G alpha(q). 相似文献
97.
Abstract We describe a case of cerebral aspergillosis which was successfully treated with a combination of caspofungin and voriconazole.
The patient remains in remission 18 months after stopping antifungal treatment. We discuss primary and salvage therapy of
invasive aspergillosis with focus on cerebral involvement. Since historical data showed a fatal outcome in most cases, amphotericin
B does not cross the blood brain barrier while voriconazole does, we chose a combination of voriconazole plus caspofungin
as primary therapy. 相似文献
98.
Mahrer AR 《American journal of psychotherapy》2007,61(3):297-312
Each experiential session is to achieve two goals. One is to enable the person to undergo a qualitative shift into being the transformed new person that the person can become. A second goal is for the qualitatively new person to be essentially free of the painful feeling and scene that were front and center for the person in the session. Each session proceeds through a sequence of steps, and each step is achieved by its own collection of working methods. 相似文献
99.
Ohne Zusammenfassung 相似文献
100.
Steinhausen HC Drechsler R Foldenyi M Imhof K Brandeis D 《Journal of the American Academy of Child and Adolescent Psychiatry》2003,42(9):1085-1092
OBJECTIVE: To study the course of attention-deficit/hyperactivity disorder (ADHD) in late childhood to adolescence using a multi-informant and multi-assessment procedure. METHOD: Subjects were 35 children with ADHD and 35 matched controls with a mean age of 10 years at first assessment. DSM-III-R-based structured diagnostic interviews and behavioral questionnaires based on parents, teachers, and youth informants were used. Cross-informant behavioral syndromes were obtained by use of the Child Behavior Checklist, the Teacher's Report Form, and the Youth Self-Report. Subjects were reassessed after 1.5 and 2.6 years. RESULTS: Behavioral differences between the two groups were significant for the majority of scales for all three informants at all three times. Diagnostic interviews revealed a persistence rate of 46% over 2.6 years. However, there were only few significant behavioral differences across informants between the nonpersistent and the persistent groups. The fit between interview-derived syndrome scores reflecting subtypes of ADHD and both parents and youth questionnaire data was good, whereas for the teacher ratings it was poor. A high rate of 89% correct classification of the outcome diagnoses was possible based on behavioral data at time 1. CONCLUSIONS: The study of the course of ADHD should be based both on interview and questionnaire data and should include several informants. Operationally defined diagnoses alone may lead to an underestimation of persistent behavioral problems. 相似文献