全文获取类型
收费全文 | 3701篇 |
免费 | 272篇 |
国内免费 | 21篇 |
专业分类
耳鼻咽喉 | 35篇 |
儿科学 | 146篇 |
妇产科学 | 116篇 |
基础医学 | 536篇 |
口腔科学 | 43篇 |
临床医学 | 400篇 |
内科学 | 858篇 |
皮肤病学 | 49篇 |
神经病学 | 342篇 |
特种医学 | 122篇 |
外科学 | 422篇 |
综合类 | 37篇 |
一般理论 | 4篇 |
预防医学 | 268篇 |
眼科学 | 78篇 |
药学 | 219篇 |
中国医学 | 13篇 |
肿瘤学 | 306篇 |
出版年
2024年 | 8篇 |
2023年 | 40篇 |
2022年 | 86篇 |
2021年 | 153篇 |
2020年 | 78篇 |
2019年 | 107篇 |
2018年 | 133篇 |
2017年 | 93篇 |
2016年 | 124篇 |
2015年 | 153篇 |
2014年 | 174篇 |
2013年 | 207篇 |
2012年 | 313篇 |
2011年 | 298篇 |
2010年 | 183篇 |
2009年 | 156篇 |
2008年 | 227篇 |
2007年 | 192篇 |
2006年 | 193篇 |
2005年 | 212篇 |
2004年 | 178篇 |
2003年 | 166篇 |
2002年 | 151篇 |
2001年 | 48篇 |
2000年 | 37篇 |
1999年 | 28篇 |
1998年 | 42篇 |
1997年 | 24篇 |
1996年 | 18篇 |
1995年 | 20篇 |
1994年 | 12篇 |
1993年 | 14篇 |
1992年 | 17篇 |
1991年 | 10篇 |
1990年 | 10篇 |
1989年 | 5篇 |
1988年 | 5篇 |
1987年 | 7篇 |
1986年 | 5篇 |
1985年 | 9篇 |
1984年 | 4篇 |
1983年 | 4篇 |
1979年 | 3篇 |
1978年 | 3篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1975年 | 9篇 |
1969年 | 3篇 |
1968年 | 5篇 |
1966年 | 2篇 |
排序方式: 共有3994条查询结果,搜索用时 15 毫秒
991.
992.
Li B Duysen EG Carlson M Lockridge O 《The Journal of pharmacology and experimental therapeutics》2008,324(3):1146-1154
Butyrylcholinesterase (BChE) is an important enzyme for metabolism of ester drugs. Many humans have partial or complete BChE deficiency due to genetic variation. Our goal was to create a mouse model of BChE deficiency to allow testing of drug toxicity. For this purpose, we created the BChE knockout mouse by gene-targeted deletion of a portion of the BCHE gene (accession number M99492). The BChE(-/-) mouse had no BChE activity in plasma, but it had low residual butyrylthiocholine hydrolase activity in all other tissues attributed to carboxylesterase ES-10. The BChE(-/-) mouse had a normal phenotype except when challenged with drugs. Nicotinic receptor function as indicated by response to nicotine seemed to be normal in BChE(-/-) mice, but muscarinic receptor function as measured by response to oxotremorine and pilocarpine was altered. Heart rate, blood pressure, and respiration, measured in a Vevo imager, were similar in BChE(+/+) and BChE(-/-) mice. Like BChE(-/-) humans, the BChE(-/-) mouse responded to succinylcholine with prolonged respiratory arrest. Bambuterol was not toxic to BChE(-/-) mice, suggesting it is safe in BChE(-/-) humans. Challenge with 150 mg/kg pilocarpine i.p., a muscarinic agonist, or with 50 mg/kg butyrylcholine i.p., induced tonicclonic convulsions and death in BChE(-/-) mice. This suggests that butyrylcholine, like pilocarpine, binds to muscarinic receptors. In conclusion, the BChE(-/-) mouse is a suitable model for human BChE deficiency. 相似文献
993.
994.
995.
Little is currently known about the neural underpinnings of the cognitive control of driving behavior in realistic situations and of the driver's speeding behavior in particular. In this study, participants drove in realistic scenarios presented in a high-end driving simulator. Scalp-recorded EEG oscillations in the alpha-band (8-13 Hz) with a 30-electrode montage were recorded while the participants drove under different conditions: (i) excessively fast (Fast), (ii) in a controlled manner at a safe speed (Correct), and (iii) impatiently in the context of testing traffic conditions (Impatient). Intracerebral sources of alpha-band activation were estimated using low resolution electrical tomography. Given that previous studies have shown a strong negative correlation between the Bold response in the frontal cortex and the alpha-band power, we used alpha-band-related activity as an estimation of frontal activation. Statistical analysis revealed more alpha-band-related activity (i.e. less neuronal activation) in the right lateral prefrontal cortex, including the dorsolateral prefrontal cortex, during fast driving. Those participants who speeded most and exhibited greater risk-taking behavior demonstrated stronger alpha-related activity (i.e. less neuronal activation) in the left anterior lateral prefrontal cortex. These findings are discussed in the context of current theories about the role of the lateral prefrontal cortex in controlling risk-taking behavior, task switching, and multitasking. 相似文献
996.
997.
Dutra L Callahan K Forman E Mendelsohn M Herman J 《The Journal of nervous and mental disease》2008,196(1):71-74
The Young Schema Questionnaire (YSQ) has been demonstrated to tap into core beliefs, or maladaptive schemas, of clinical populations. This study used the YSQ to investigate maladaptive schemas of 137 chronically traumatized patients seeking outpatient psychiatric treatment and to assess whether specific schemas might be associated with suicide risk in this population. Participants completed a modified version of the YSQ-S (short form), post-traumatic diagnostic scale, dissociative experiences scale and self-harm and risk behaviors questionnaire-revised at treatment intake. Significant correlations were found between most YSQ scales and the post-traumatic diagnostic scale, and between all YSQ scales and the dissociative experiences scale. Suicide risk variables were most highly correlated with the social isolation/alienation, defectiveness/shame and failure YSQ scales, suggesting that these schemas may mark individuals at particularly high risk for suicidal ideation and suicide attempts. These results offer important implications for the assessment and treatment of high-risk traumatized patients. 相似文献
998.
999.
1000.