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51.
Roeder PL Taylor WP 《Revue scientifique et technique (International Office of Epizootics)》2007,26(1):253-263
The design of effective programmes for emergency response to incursion of epizootic diseases of cattle, for exclusion of such diseases and for implementation of progressive control in enzootic situations leading to eventual virus elimination, is currently largely empirical. This needs to be remedied to provide more cost-effective use of vaccines and more effective control. At population level, protective effects of immunisation can extend well beyond the individual, influencing the dynamics of viral propagation within the whole population, non-vaccinated as well as vaccinated. This concept of herd immunity and application of the resulting epidemiological principles, combined with experience gained from disease control programmes such as the Global Rinderpest Eradication Programme has much to offer in designing effective science-based control programmes. This paper explores practical exploitation of the herd immunity principle by considering some of the factors which militate against mass vaccination achieving effective levels of herd immunity and, with these in mind, suggesting ways to optimise the efficiency of mass vaccination programmes. 相似文献
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Oertel S Treiber M Zahlten-Hinguranage A Eichin S Roeder F Funk A Hensley FW Timke C Niethammer AG Huber PE Weitz J Eble MJ Buchler MW Bernd L Debus J Krempien RC 《International journal of radiation oncology, biology, physics》2006,64(5):1416-1423
PURPOSE: To analyze long-term prognosis and morbidity after limb-sparing treatment of patients with extremity soft-tissue sarcoma, with intraoperative electron boost radiotherapy (IOERT) followed by a moderate dose of external beam radiotherapy (EBRT). METHODS AND MATERIALS: A total of 153 patients who were treated in a single center from 1991 to 2004 were evaluated. Median IOERT dose was 15 Gy, mean EBRT dose 43 Gy (range, 40-50.4 Gy) in conventional fractionation (1.8-2 Gy). Median duration of follow-up was 33 months. Acute toxicity was assessed with Common Toxicity Criteria; late toxic effects were scored according to European Organization for Research and Treatment of Cancer/Radiation Therapy Oncology Group criteria. RESULTS: Five-year overall survival and 5-year local control rates were 77% and 78%, respectively. Whereas tumor size, patient age, and EBRT dose did not significantly affect outcome, resection status and grading were significant for survival; resection status and IOERT dose were significant for local control. Extremity salvage until death or time of follow-up was achieved in 90% of our patients, 86% of whom showed excellent limb function without impairment in activities of daily life. Acute toxicity Grade 2-4 was observed in 23% and late toxicity Grade 2-4 in 17% of patients. CONCLUSIONS: Treatment with IOERT combined with moderate doses of external beam irradiation yields high local control and extremity preservation rates in resected extremity soft-tissue sarcoma. 相似文献
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Recombinant yeast TFIID, a general transcription factor, mediates activation by the gene-specific factor USF in a chromatin assembly assay. 总被引:14,自引:1,他引:13
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57.
ACUTE INFLAMMATORY OBSTRUCTION OF TERMINAL ILEUM 总被引:1,自引:1,他引:0
Roeder CA 《Annals of surgery》1928,87(6):867-869
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Hatch KA Spangler DL Backus EM Balagna JT Burns KS Guzman BS Hubbard MJ Lindblad SL Roeder BL Ryther NE Seawright MA Tyau JN Williams D 《Expert review of molecular diagnostics》2007,7(6):845-857
Diagnosis of anorexia nervosa (AN) and bulimia nervosa (BN), while including such physiological data as weight and the reproductive status of the individual, are primarily based on questionnaires and interviews that rely on self-report of both body-related concerns and eating-related behaviors. While some key components of eating disorders are psychological and thus introspective in nature, reliance on self-report for the assessment of eating-related behaviors and nutritional status lacks the objectivity that a physiologically based measure could provide. The development of a more physiologically informed diagnosis for AN and BN would provide a more objective means of diagnosing these disorders, provide a sound physiological basis for diagnosing subclinical disorders and could also aid in monitoring the effectiveness of treatments for these disorders. Empirically supported, physiologically based methods for diagnosing AN and BN are reviewed herein as well as promising physiological measures that may potentially be used in the diagnosis of AN and BN. 相似文献